Vanderbilt University School of Medicine

Cherrington, Alan D. , Ph.D.
Professor of Molecular Physiology and Biophysics
Professor of Medicine
Jacquelyn A. Turner and Dr. Dorothy J. Turner Chair in Diabetes Research

Lab Url: http://www.mc.vanderbilt.edu/adclab/

Phone Number: 615-322-7013

Email Address:alan.cherrington@vanderbilt.edu

Cherrington, Alan's picture

Office Address   Mailing Address

704A/710 Robinson Research Bldg

702 Light Hall 704A Robinson Research Bldg 37232-0615


Research Keywords
diabetes, glycogenolysis, gluconeogenesis, physiology

Research Description
A decade ago the synthesis of glycogen which occurs in the liver after oral glucose feeding was thought to be the result of the ingested glucose triggering insulin release and the insulin in turn causing the liver to take up and store the glucose. It is now clear that this storage response is much more complicated than first thought. We now know that another signal, as yet poorly understood, is involved in activating the liver, and further, that much of the glycogen deposited does not come "directly" from ingested glucose but "indirectly" from 3-carbon precursors which enter liver glycogen via the gluconeogenic pathway. We are currently using a chronically catheterized dog model to study the physiology of this "new" signal and the conditions under which liver glycogen is synthesized via the "direct" or "indirect" routes.

Remarkably, if the body is exposed to an insulin level 30 times normal, the resulting hypoglycemia will be limited to a level compatible with life. The reason for this life saving response is that the stimulatory effect of insulin on glucose utilization and its inhibitory effect on glucose production are limited by a variety of hormonal and neural mechanisms. We are currently investigating the role of each mechanism in limiting insulin induced hypoglycemia using conscious dogs. In addition, we are studying the ability of the brain to sense and respond directly to insulin via vertebral and carotid artery infusion or insulin infusion into the 3rd ventricle. We are also examining the defects which occur in counterregulation in diabetes.

We continue to define the actions of various hormones (insulin, glucagon, epinephrine, cortisol) and neural mediators (norepinephrine, acetylcholine, cGRP, NPY) and drugs on glucose production (glycogenolysis and gluconeogenesis) and utilization by the liver.

Our experiments are carried out in vivo using transgenic mice, the conscious dog and man or in vitro using perfused liver and isolated liver cells. Control over various aspects of the endocrine and/or nervous system is gained using pharmacologic and/or surgical techniques. The rates of glucose production (glycogenolysis; gluconeogenesis) and utilization, as well as ketone body production and clearance are assessed using tracer and arteriovenous differences techniques.
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Publications
An Z, Dicostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. Am J Physiol Endocrinol Metab, 294(2), E300-E306, 2008.

Cherrington, AD. Central versus peripheral glucose sensing and the response to hypoglycemia. Diabetes, 57(5), 1158-9, 2008.

Johnson, KM, Edgerton, DS, Rodewald, TD, Scott, M, Farmer, B, Neal, DW, Cherrington, AD. Intraportally Delivered GLP-1, in the Presence of Hyperglycemia Induced via Peripheral Glucose Infusion, Does Not Change Whole Body Glucose Utilization. Am J Physiol Endocrinol Metab, 294(2), E380-4, 2008.

Moore, MC, Dicostanzo, CA, Smith, MS, Farmer, B, Rodewald, TD, Neal, DW, Williams, PE, Cherrington, AD. Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Am J Physiol Endocrinol Metab, 294(4), E768-77, 2008.

Nishizawa, M, Shiota, M, Moore, MC, Gustavson, SM, Neal, DW, Cherrington, AD. Intraportal administration of neuropeptide Y and hepatic glucose metabolism. Am J Physiol Regul Integr Comp Physiol, 294(4), R1197-204, 2008.

DiCostanzo, CA, Dardevet, DP, Williams, PE, Courtney Moore, M, Hastings, JR, Neal, DW, Cherrington, AD. The effect of vagal cooling on canine hepatic glucose metabolism in the presence of hyperglycemia of peripheral origin. Metabolism, 56(6), 814-24, 2007.

Johnson, KM, Edgerton, DS, Rodewald, T, Scott, M, Farmer, B, Neal, D, Cherrington, AD. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Am J Physiol Endocrinol Metab, 293(4), E1085-91, 2007.

Nelson, RH, Edgerton, DS, Basu, R, Roesner, JC, Cherrington, AD, Miles, JM. Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes, 56(7), 1850-5, 2007.

Rivera, N, Everett-Grueter, CA, Edgerton, DS, Rodewald, T, Neal, DW, Nishimura, E, Larsen, MO, Jacobsen, LO, Kristensen, K, Brand, CL, Cherrington, AD. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther, 321, 743-752, 2007.

Basu, R, Edgerton, DS, Singh, RJ, Cherrington, A, Rizza, RA. Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity. Diabetes, 55(11), 3013-9, 2006.

Dicostanzo, CA, Dardevet, DP, Neal, DW, Lautz, M, Allen, E, Snead, W, Cherrington, AD. Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. Am J Physiol Endocrinol Metab, 290(1), E9-E16, 2006.

Edgerton, DS, Cherrington, AD, Williams, P, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Kuo, MC, Strack, TR. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Diabetes, 55(12), 3604-10, 2006.

Edgerton, DS, Jacobson, PB, Opgenorth, TJ, Zinker, B, Beno, D, von Geldern, T, Ohman, L, Scott, M, Neal, D, Cherrington, AD. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Metabolism, 55(9), 1255-62, 2006.

Edgerton, DS, Lautz, M, Scott, M, Everett, CA, Stettler, KM, Neal, DW, Chu, CA, Cherrington, AD. Insulin''s direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest, 116(2), 521-7, 2006. PMCID:1359060

Edgerton, DS, Stettler, KM, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Strack, TR, Cherrington, AD. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. J Pharmacol Exp Ther, 319(3), 1258-64, 2006.

Everett-Grueter, C, Edgerton, DS, Donahue, EP, Vaughan, S, Chu, CA, Sindelar, DK, Cherrington, AD. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Am J Physiol Endocrinol Metab, 291(3), E449-59, 2006.

Cherrington, AD. The role of hepatic insulin receptors in the regulation of glucose production. J Clin Invest, 115(5), 1136-9, 2005. PMCID:1087191

Dardevet, D, Moore, MC, DiCostanzo, CA, Farmer, B, Neal, DW, Snead, W, Lautz, M, Cherrington, AD. Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors. Am J Physiol Gastrointest Liver Physiol, 289(5), G806-14, 2005. PMCID:2435373

DiCostanzo, CA, Moore, MC, Lautz, M, Scott, M, Farmer, B, Everett, CA, Still, JG, Higgins, A, Cherrington, AD. Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia. Am J Physiol Endocrinol Metab, 289(1), E46-52, 2005.

Edgerton, DS, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Sivakumaran, S, Strack, TR, Cherrington, AD. Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Diabetes, 54(4), 1164-70, 2005.

Grubert, JM, Lautz, M, Lacy, DB, Moore, MC, Farmer, B, Penaloza, A, Cherrington, AD, McGuinness, OP. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. Am J Physiol Endocrinol Metab, 289(2), E232-40, 2005.

Gustavson, SM, Rajotte, RV, Hunkeler, D, Lakey, JR, Edgerton, DS, Neal, DW, Snead, WL, Penaloza, AR, Cherrington, AD. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am J Transplant, 5(10), 2368-77, 2005.

Jacobson, PB, von Geldern, TW, Ohman, L, Osterland, M, Wang, J, Zinker, B, Wilcox, D, Nguyen, PT, Mika, A, Fung, S, Fey, T, Goos-Nilsson, A, Grynfarb, M, Barkhem, T, Marsh, K, Beno, DW, Nga-Nguyen, B, Kym, PR, Link, JT, Tu, N, Edgerton, DS, Cherrington, A, Efendic, S, Lane, BC, Opgenorth, TJ. Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J Pharmacol Exp Ther, 314(1), 191-200, 2005.

Moore, MC, DiCostanzo, CA, Dardevet, D, Lautz, M, Farmer, B, Cherrington, AD. Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs. Am J Physiol Endocrinol Metab, 288(3), E556-63, 2005.

Moore, MC, Kimura, K, Shibata, H, Honjoh, T, Saito, M, Everett, CA, Smith, MS, Cherrington, AD. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am J Physiol Endocrinol Metab, 289(2), E225-31, 2005. PMCID:2430063

Shiota, M, Galassetti, P, Igawa, K, Neal, DW, Cherrington, AD. Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog. Am J Physiol Endocrinol Metab, 288(6), E1160-7, 2005.

Cardin, S, Pagliassotti, MJ, Moore, MC, Edgerton, DS, Lautz, M, Farmer, B, Neal, DW, Cherrington, AD. Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs. Am J Physiol Regul Integr Comp Physiol, 287(4), R742-8, 2004.

Cherrington, AD, Neal, DW, Edgerton, DS, Glass, D, Bowen, L, Hobbs, CH, Leach, C, Rosskamp, R, Strack, TR. Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes, 53(4), 877-81, 2004.

Chu, CA, Fujimoto, Y, Igawa, K, Grimsby, J, Grippo, JF, Magnuson, MA, Cherrington, AD, Shiota, M. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am J Physiol Gastrointest Liver Physiol, 286(4), G627-34, 2004.

Dardevet, D, Moore, MC, Neal, D, DiCostanzo, CA, Snead, W, Cherrington, AD. Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Am J Physiol Endocrinol Metab, 287(1), E75-81, 2004.

Edgerton, DS, Cardin, S, Neal, D, Farmer, B, Lautz, M, Pan, C, Cherrington, AD. Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Am J Physiol Endocrinol Metab, 286(4), E510-22, 2004.

Gustavson, SM, Chu, CA, Nishizawa, M, Neal, D, Farmer, B, Yang, Y, Donahue, EP, Flakoll, P, Cherrington, AD. Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. Metabolism, 53(7), 933-41, 2004.

Hornbuckle, LA, Everett, CA, Martin, CC, Gustavson, SS, Svitek, CA, Oeser, JK, Neal, DW, Cherrington, AD, O''Brien, RM. Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Am J Physiol Endocrinol Metab, 286(5), E795-808, 2004.

Moore, MC, Cardin, S, Edgerton, DS, Farmer, B, Neal, DW, Lautz, M, Cherrington, AD. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am J Physiol Endocrinol Metab, 286(2), E226-33, 2004.

Moore, MC, DiCostanzo, CA, Dardevet, D, Lautz, M, Farmer, B, Neal, DW, Cherrington, AD. Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Am J Physiol Endocrinol Metab, 287(6), E1057-63, 2004.

Moore, MC, Geho, WB, Lautz, M, Farmer, B, Neal, DW, Cherrington, AD. Portal serotonin infusion and glucose disposal in conscious dogs. Diabetes, 53(1), 14-20, 2004.

Moore, MC, Satake, S, Lautz, M, Soleimanpour, SA, Neal, DW, Smith, M, Cherrington, AD. Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog. Diabetes, 53(1), 32-40, 2004.

Chu, CA, Galassetti, P, Igawa, K, Sindelar, DK, Neal, DW, Burish, M, Cherrington, AD. Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs. Am J Physiol Endocrinol Metab, 284(2), E291-301, 2003.

Gustavson, SM, Chu, CA, Nishizawa, M, Farmer, B, Neal, D, Yang, Y, Donahue, EP, Flakoll, P, Cherrington, AD. Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Am J Physiol Endocrinol Metab, 284(4), E695-707, 2003.

Gustavson, SM, Chu, CA, Nishizawa, M, Farmer, B, Neal, D, Yang, Y, Vaughan, S, Donahue, EP, Flakoll, P, Cherrington, AD. Glucagon''s actions are modified by the combination of epinephrine and gluconeogenic precursor infusion. Am J Physiol Endocrinol Metab, 285(3), E534-44, 2003.

Gustavson, SM, Nishizawa, M, Farmer, B, Neal, D, Brissova, M, Powers, AC, Cherrington, AD. A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs. Metabolism, 52(11), 1418-25, 2003.

Jensen, MD, Cardin, S, Edgerton, D, Cherrington, A. Splanchnic free fatty acid kinetics. Am J Physiol Endocrinol Metab, 284(6), E1140-8, 2003.

Moore, MC, Burish, MJ, Farmer, B, Neal, DW, Pan, C, Cherrington, AD. Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery. Am J Physiol Endocrinol Metab, 285(4), E845-53, 2003.

Moore, MC, Cherrington, AD, Wasserman, DH. Regulation of hepatic and peripheral glucose disposal. Best Pract Res Clin Endocrinol Metab, 17(3), 343-64, 2003.

Nishizawa, M, Moore, MC, Shiota, M, Gustavson, SM, Snead, WL, Neal, DW, Cherrington, AD. Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. Am J Physiol Endocrinol Metab, 284(5), E1027-36, 2003.

Cardin, S, Walmsley, K, Neal, DW, Williams, PE, Cherrington, AD. Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs. Am J Physiol Endocrinol Metab, 283(5), E958-64, 2002.

Cherrington, AD, Sindelar, D, Edgerton, D, Steiner, K, McGuinness, OP. Physiological consequences of phasic insulin release in the normal animal. Diabetes, 51 Suppl 1, S103-8, 2002.

Chu, CA, Sherck, SM, Igawa, K, Sindelar, DK, Neal, DW, Emshwiller, M, Cherrington, AD. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. Am J Physiol Endocrinol Metab, 282(2), E402-11, 2002.

Dunning, BE, Moore, MC, Ikeda, T, Neal, DW, Scott, MF, Cherrington, AD. Evidence for a neurally-mediated incretin effect of portal vs peripheral glucose infusion in conscious dogs. Metabolism, 51, 1324-30, 2002.

Edgerton, DS, Cardin, S, Pan, C, Neal, D, Farmer, B, Converse, M, Cherrington, AD. Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Diabetes, 51(11), 3151-62, 2002.

Goldstein, RE, Rossetti, L, Palmer, BA, Liu, R, Massillon, D, Scott, M, Neal, D, Williams, P, Peeler, B, Cherrington, AD. Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo. Am J Physiol Endocrinol Metab, 283(5), E946-57, 2002.

Igawa, K, Mugavero, M, Shiota, M, Neal, DW, Cherrington, AD. Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog. Diabetes, 51(10), 3033-42, 2002.

Moore, MC, Cherrington, AD, Palmer, B, Lacy, DB, Goldstein, RE. Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation. JPEN J Parenter Enteral Nutr, 26(1), 42-50, 2002.

Moore, MC, Satake, S, Baranowski, B, Hsieh, PS, Neal, DW, Cherrington, AD. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am J Physiol Endocrinol Metab, 282(2), E286-96, 2002.

Satake, S, Moore, MC, Igawa, K, Converse, M, Farmer, B, Neal, DW, Cherrington, AD. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes, 51(6), 1663-71, 2002.

Shiota, M, Moore, MC, Galassetti, P, Monohan, M, Neal, DW, Shulman, GI, Cherrington, AD. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes, 51(2), 469-78, 2002.

Cardin, S, Jackson, PA, Edgerton, DS, Neal, DW, Coffey, CS, Cherrington, AD. Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog. Diabetes, 50(3), 558-64, 2001.

Edgerton, DS, Cardin, S, Emshwiller, M, Neal, D, Chandramouli, V, Schumann, WC, Landau, BR, Rossetti, L, Cherrington, AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes, 50(8), 1872-82, 2001.

Flattem, N, Igawa, K, Shiota, M, Emshwiller, MG, Neal, DW, Cherrington, AD. Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. Diabetes, 50(2), 367-75, 2001.

Hornbuckle, LA, Edgerton, DS, Ayala, JE, Svitek, CA, Oeser, JK, Neal, DW, Cardin, S, Cherrington, AD, O''Brien, RM. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Am J Physiol Endocrinol Metab, 281(4), E713-25, 2001.

Jetton, TL, Shiota, M, Knobel, SM, Piston, DW, Cherrington, AD, Magnuson, MA. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int J Exp Diabetes Res, 2(3), 173-86, 2001. PMCID:2478546

Moore, MC, Davis, SN, Mann, SL, Cherrington, AD. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care, 24(11), 1882-7, 2001.

Sherck, SM, Shiota, M, Saccomando, J, Cardin, S, Allen, EJ, Hastings, JR, Neal, DW, Williams, PE, Cherrington, AD. Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input. Diabetes, 50(11), 2487-96, 2001.

Shiota, M, Postic, C, Fujimoto, Y, Jetton, TL, Dixon, K, Pan, D, Grimsby, J, Grippo, JF, Magnuson, MA, Cherrington, AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes, 50(3), 622-9, 2001.

Chu, CA, Sindelar, DK, Igawa, K, Sherck, S, Neal, DW, Emshwiller, M, Cherrington, AD. The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog. Am J Physiol Endocrinol Metab, 279(2), E463-73, 2000.

Chu, CA, Wiernsperger, N, Muscato, N, Knauf, M, Neal, DW, Cherrington, AD. The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metabolism, 49(12), 1619-26, 2000.

Connolly, CC, Holste, LC, Aglione, LN, Neal, DW, Lacy, DB, Smith, MS, Diamond, MP, Cherrington, AD, Chiasson, JL. Alterations in basal glucose metabolism during late pregnancy in the conscious dog. Am J Physiol Endocrinol Metab, 279(5), E1166-77, 2000.

Hsieh, PS, Moore, MC, Neal, DW, Cherrington, AD. Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs. Am J Physiol Endocrinol Metab, 279(2), E284-92, 2000.

Jackson, PA, Cardin, S, Coffey, CS, Neal, DW, Allen, EJ, Penaloza, AR, Snead, WL, Cherrington, AD. Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am J Physiol Endocrinol Metab, 279(6), E1249-57, 2000.

Moore, MC, Cherrington, AD, Mann, SL, Davis, SN. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab, 85(12), 4515-9, 2000.

Moore, MC, Cherrington, AD, Palmer, B, Lacy, DB, Goldstein, RE. Disposition of a mixed meal by conscious dogs after seven days of treatment with cyclosporine A and prednisone. JPEN J Parenter Enteral Nutr, 24(4), 244-50, 2000.

Moore, MC, Hsieh, PS, Neal, DW, Cherrington, AD. Nonhepatic response to portal glucose delivery in conscious dogs. Am J Physiol Endocrinol Metab, 279(6), E1271-7, 2000.

Shiota, M, Jackson, P, Galassetti, P, Scott, M, Neal, DW, Cherrington, AD. Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. Am J Physiol Endocrinol Metab, 278(3), E544-52, 2000.

Cardin, S, Emshwiller, M, Jackson, PA, Snead, WL, Hastings, J, Edgerton, DS, Cherrington, AD. Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats. J Appl Physiol, 87(4), 1470-5, 1999.

Cherrington, AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes, 48(5), 1198-214, 1999.

Chu, CA, Sindelar, DK, Neal, DW, Cherrington, AD. Hepatic and gut clearance of catecholamines in the conscious dog. Metabolism, 48(2), 259-63, 1999.

Galassetti, P, Chu, CA, Neal, DW, Reed, GW, Wasserman, DH, Cherrington, AD. A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am J Physiol, 277(1 Pt 1), E126-34, 1999.

Galassetti, P, Coker, RH, Lacy, DB, Cherrington, AD, Wasserman, DH. Prior exercise increases net hepatic glucose uptake during a glucose load. Am J Physiol, 276(6 Pt 1), E1022-9, 1999.

Galassetti, P, Hamilton, KS, Gibbons, FK, Bracy, DP, Lacy, DB, Cherrington, AD, Wasserman, DH. Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog. Am J Physiol, 276(3 Pt 1), E543-52, 1999.

Galassetti, P, Koyama, Y, Coker, RH, Lacy, DB, Cherrington, AD, Wasserman, DH. Role of a negative arterial-portal venous glucose gradient in the postexercise state. Am J Physiol, 277(6 Pt 1), E1038-45, 1999.

Hsieh, PS, Moore, MC, Marshall, B, Pagliassotti, MJ, Shay, B, Szurkus, D, Neal, DW, Cherrington, AD. The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs. Am J Physiol, 277(4 Pt 1), E678-84, 1999.

Hsieh, PS, Moore, MC, Neal, DW, Emshwiller, M, Cherrington, AD. Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog. Am J Physiol, 276(5 Pt 1), E930-7, 1999.

McGuinness, OP, Snowden, RT, Moran, C, Neal, DW, Fujiwara, T, Cherrington, AD. Impact of acute epinephrine removal on hepatic glucose metabolism during stress hormone infusion. Metabolism, 48(7), 910-4, 1999.

Moore, MC, Hsieh, PS, Flakoll, PJ, Neal, DW, Cherrington, AD. Net hepatic gluconeogenic amino acid uptake in response to peripheral versus portal amino acid infusion in conscious dogs. J Nutr, 129(12), 2218-24, 1999.

Moore, MC, Hsieh, PS, Flakoll, PJ, Neal, DW, Cherrington, AD. Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. Am J Physiol, 276(2 Pt 1), E295-302, 1999.

Moore, MC, Lin, DW, Colburn, CA, Goldstein, RE, Neal, DW, Cherrington, AD. Insulin- and glucagon-independent effects of calcitonin gene-related peptide in the conscious dog. Metabolism, 48(5), 603-10, 1999.

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999.

Sindelar, DK, Igawa, K, Chu, CA, Balcom, JH, Neal, DW, Cherrington, AD. Effect of a selective rise in hepatic artery insulin on hepatic glucose production in the conscious dog. Am J Physiol, 276(4 Pt 1), E806-13, 1999.

Cherrington, AD, Edgerton, D, Sindelar, DK. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia, 41(9), 987-96, 1998.

Chu, CA, Sindelar, DK, Neal, DW, Allen, EJ, Donahue, EP, Cherrington, AD. Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis. Am J Physiol, 274(1 Pt 1), E162-71, 1998.

Dobbins, RL, Davis, SN, Neal, D, Caumo, A, Cobelli, C, Cherrington, AD. Rates of glucagon activation and deactivation of hepatic glucose production in conscious dogs. Metabolism, 47(2), 135-42, 1998.

Galassetti, P, Gibbons, FK, Hamilton, KS, Lacy, DB, Cherrington, AD, Wasserman, DH. Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle. J Appl Physiol, 84(6), 1952-9, 1998.

Galassetti, P, Shiota, M, Zinker, BA, Wasserman, DH, Cherrington, AD. A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am J Physiol, 275(1 Pt 1), E101-11, 1998.

Hsieh, PS, Moore, MC, Neal, DW, Cherrington, AD. Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs. Am J Physiol, 275(6 Pt 1), E987-92, 1998.

Moore, MC, Connolly, CC, Cherrington, AD. Autoregulation of hepatic glucose production. Eur J Endocrinol, 138(3), 240-8, 1998.

Moore, MC, Flakoll, PJ, Hsieh, PS, Pagliassotti, MJ, Neal, DW, Monohan, MT, Venable, C, Cherrington, AD. Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. Am J Physiol, 274(5 Pt 1), E893-902, 1998.

Shiota, M, Galassetti, P, Monohan, M, Neal, DW, Cherrington, AD. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes, 47(6), 867-73, 1998.

Sindelar, DK, Chu, CA, Venson, P, Donahue, EP, Neal, DW, Cherrington, AD. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes, 47(4), 523-9, 1998.

Balcom, J, Sindelar, D, Neal, D, Cherrington, AD. Troglitazone does not sensitize the liver to insulin in the normal dog. Diabetes Research, 32, 115-132, 1997.

Chu, CA, Sindelar, DK, Neal, DW, Allen, EJ, Donahue, EP, Cherrington, AD. Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest, 99(5), 1044-56, 1997. PMCID:507913

Chu, CA, Sindelar, DK, Neal, DW, Cherrington, AD. Portal adrenergic blockade does not inhibit the gluconeogenic effects of circulating catecholamines on the liver. Metabolism, 46(4), 458-65, 1997.

Davis, SN, Dunham, B, Walmsley, K, Shavers, C, Neal, D, Williams, P, Cherrington, AD. Brain of the conscious dog is sensitive to physiological changes in circulating insulin. Am J Physiol, 272(4 Pt 1), E567-75, 1997.

Dunning, BE, Scott, MF, Neal, DW, Cherrington, AD. Direct quantification of norepinephrine spillover and hormone output from the pancreas of the conscious dog. Am J Physiol, 272(5 Pt 1), E746-55, 1997.

Holste, LC, Connolly, CC, Moore, MC, Neal, DW, Cherrington, AD. Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am J Physiol, 273(3 Pt 1), E488-96, 1997.

Jackson, PA, Pagliassotti, MJ, Shiota, M, Neal, DW, Cardin, S, Cherrington, AD. Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am J Physiol, 273(6 Pt 1), E1178-88, 1997.

McGuinness, OP, Shau, V, Benson, EM, Lewis, M, Snowden, RT, Greene, JE, Neal, DW, Cherrington, AD. Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog. Am J Physiol, 273(4 Pt 1), E674-81, 1997.

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997.

Shiota, M, Jackson, PA, Bischoff, H, McCaleb, M, Scott, M, Monohan, M, Neal, DW, Cherrington, AD. Inhibition of glycogenolysis enhances gluconeogenic precursor uptake by the liver of conscious dogs. Am J Physiol, 273(5 Pt 1), E868-79, 1997.

Sindelar, DK, Chu, CA, Neal, DW, Cherrington, AD. Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog. Am J Physiol, 273(5 Pt 1), E972-80, 1997.

Sindelar, DK, Chu, CA, Rohlie, M, Neal, DW, Swift, LL, Cherrington, AD. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes, 46(2), 187-96, 1997.

Chu, CA, Sindelar, DK, Neal, DW, Cherrington, AD. Direct effects of catecholamines on hepatic glucose production in conscious dog are due to glycogenolysis. Am J Physiol, 271(1 Pt 1), E127-37, 1996.

Connolly, CC, Ivy, RE, Adkins-Marshall, BA, Dobbins, RL, Neal, DW, Williams, PE, Cherrington, AD. Counterregulation by epinephrine and glucagon during insulin-induced hypoglycemia in the conscious dog. Diabetes Res Clin Pract, 31(1-3), 45-56, 1996.

Connolly, CC, Myers, SR, Neal, DW, Hastings, JR, Cherrington, AD. In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain. Diabetes, 45(12), 1805-13, 1996.

Donnelly, JE, Jacobsen, DJ, Whatley, JE, Hill, JO, Swift, LL, Cherrington, A, Polk, B, Tran, ZV, Reed, G. Nutrition and physical activity program to attenuate obesity and promote physical and metabolic fitness in elementary school children. Obes Res, 4(3), 229-43, 1996.

Fujiwara, T, Cherrington, AD, Neal, DN, McGuinness, OP. Role of cortisol in the metabolic response to stress hormone infusion in the conscious dog. Metabolism, 45(5), 571-8, 1996.

Hamilton, KS, Gibbons, FK, Bracy, DP, Lacy, DB, Cherrington, AD, Wasserman, DH. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J Clin Invest, 98(1), 125-35, 1996. PMCID:507408

Moore, MC, Cherrington, AD. Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms. Reprod Nutr Dev, 36(4), 399-406, 1996.

Moore, MC, Cherrington, AD. The nerves, the liver, and the route of feeding: an integrated response to nutrient delivery. Nutrition, 12(4), 282-4, 1996.

Moore, MC, Rossetti, L, Pagliassotti, MJ, Monahan, M, Venable, C, Neal, D, Cherrington, AD. Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. Am J Physiol, 271(2 Pt 1), E215-22, 1996.

Pagliassotti, MJ, Holste, LC, Moore, MC, Neal, DW, Cherrington, AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest, 97(1), 81-91, 1996. PMCID:507065

Shiota, M, Green, R, Colburn, CA, Mitchell, G, Cherrington, AD. Inability of hyperglycemia to counter the ability of glucagon to increase net glucose output and activate glycogen phosphorylase in the perfused rat liver. Metabolism, 45(4), 481-5, 1996.

Sindelar, DK, Balcom, JH, Chu, CA, Neal, DW, Cherrington, AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes, 45(11), 1594-604, 1996.

Wang, DZ, Cherrington, A, Famakin-Mosuro, B, Boothby, M. Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element. Int Immunol, 8(7), 977-89, 1996.

Davis, SN, Colburn, C, Dobbins, R, Nadeau, S, Neal, D, Williams, P, Cherrington, AD. Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest, 95(2), 593-602, 1995. PMCID:295522

Davis, SN, Dobbins, R, Tarumi, C, Jacobs, J, Neal, D, Cherrington, AD. Paradoxical insulin-induced increase in gluconeogenesis in response to prolonged hypoglycemia in conscious dogs. Am J Physiol, 268(3 Pt 1), E521-30, 1995.

Dobbins, RL, Davis, SN, Neal, DW, Cobelli, C, Jaspan, J, Cherrington, AD. Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism, 44(4), 452-9, 1995.

Goldstein, RE, Abumrad, NN, Lacy, DB, Wasserman, DH, Cherrington, AD. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes, 44(6), 672-81, 1995.

Wada, M, Connolly, CC, Tarumi, C, Neal, DW, Cherrington, AD. Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs. Am J Physiol, 268(2 Pt 1), E194-203, 1995.

Cherrington, AD, Wasserman, DH, McGinness, OP. Renal contribution to glucose production after a brief fast: fact or fancy. J Clin Invest, 93(6), 2303, 1994. PMCID:294432

Davis, SN, Goldstein, RE, Cherrington, AD, Price, L. Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject. Diabetes Res Clin Pract, 22(2-3), 139-46, 1994.

Davis, SN, Shavers, C, Collins, L, Cherrington, AD, Price, L, Hedstrom, C. Effects of physiological hyperinsulinemia on counterregulatory response to prolonged hypoglycemia in normal humans. Am J Physiol, 267(3 Pt 1), E402-10, 1994.

Dobbins, RL, Davis, SN, Neal, DW, Cobelli, C, Cherrington, AD. Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol, 266(3 Pt 1), E467-78, 1994.

Goldstein, RE, Cherrington, AD, Reed, GW, Lacy, DB, Wasserman, DH, Abumrad, NN. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am J Physiol, 266(4 Pt 1), E618-27, 1994.

Goldstein, RE, Wasserman, DH, Reed, GW, Lacy, DB, Abumrad, NN, Cherrington, AD. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm Metab Res, 26(1), 9-13, 1994.

McGuinness, OP, Burgin, K, Moran, C, Bracy, D, Cherrington, AD. Role of glucagon in the metabolic response to stress hormone infusion in the conscious dog. Am J Physiol, 266(3 Pt 1), E438-47, 1994.

McGuinness, OP, Murrell, S, Moran, C, Bracy, D, Cherrington, AD. The effect of acute glucagon removal on the metabolic response to stress hormone infusion in the conscious dog. Metabolism, 43(10), 1310-7, 1994.

Moore, MC, Pagliassotti, MJ, Goldstein, RE, Asher, J, Murrell, J, Neal, D, Cherrington, AD. The effect of the hepatic nerves on the disposition of a mixed meal by conscious dogs. JPEN J Parenter Enteral Nutr, 18(3), 248-55, 1994.

Moore, MC, Pagliassotti, MJ, Swift, LL, Asher, J, Murrell, J, Neal, D, Cherrington, AD. Disposition of a mixed meal by the conscious dog. Am J Physiol, 266(4 Pt 1), E666-75, 1994.

Cherrington, AD, Stevenson, RW, Steiner, KE, Connolly, CC, Wada, M, Goldstein, RE. Acute hormonal regulation of gluconeogenesis in the conscious dog. Adv Exp Med Biol, 334, 199-208, 1993.

Connolly, CC, Stevenson, RW, Neal, DW, Wasserman, DH, Cherrington, AD. The effects of lactate loading on alanine and glucose metabolism in the conscious dog. Metabolism, 42(2), 154-61, 1993.

Davis, SN, Cherrington, AD. The hormonal and metabolic responses to prolonged hypoglycemia. J Lab Clin Med, 121(1), 21-31, 1993.

Davis, SN, Cherrington, AD, Goldstein, RE, Jacobs, J, Price, L. Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am J Physiol, 265(5 Pt 1), E680-9, 1993.

Davis, SN, Dobbins, R, Colburn, C, Tarumi, C, Jacobs, J, Neal, D, Cherrington, AD. Effects of hyperinsulinemia on the subsequent hormonal response to hypoglycemia in conscious dogs. Am J Physiol, 264(5 Pt 1), E748-55, 1993.

Davis, SN, Goldstein, RE, Jacobs, J, Price, L, Wolfe, R, Cherrington, AD. The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Diabetes, 42(2), 263-72, 1993.

Davis, SN, Goldstein, RE, Price, L, Jacobs, J, Cherrington, AD. The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab, 77(5), 1300-7, 1993.

Frizzell, RT, Jones, EM, Davis, SN, Biggers, DW, Myers, SR, Connolly, CC, Neal, DW, Jaspan, JB, Cherrington, AD. Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes, 42(9), 1253-61, 1993.

Goldstein, RE, Wasserman, DH, McGuinness, OP, Lacy, DB, Cherrington, AD, Abumrad, NN. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am J Physiol, 264(1 Pt 1), E119-27, 1993.

McGuinness, OP, Fugiwara, T, Murrell, S, Bracy, D, Neal, D, O''Connor, D, Cherrington, AD. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol, 265(2 Pt 1), E314-22, 1993.

Moore, MC, Pagliassotti, MJ, Wasserman, DH, Goldstein, R, Asher, J, Neal, DW, Cherrington, AD. Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs. J Nutr, 123(10), 1739-46, 1993.

Moore, MC, Shulman, GI, Giaccari, A, Pagliassotti, MJ, Cline, G, Neal, D, Rossetti, L, Cherrington, AD. Effect of hepatic nerves on disposition of an intraduodenal glucose load. Am J Physiol, 265(3 Pt 1), E487-96, 1993.

Myers, S, Ivy, R, Cherrington, AD, Diamond, MP. Effect of norgestrel on intermediary metabolism in the conscious dog. Endocrine Journal, 1, 93-99, 1993.

Pagliassotti, MJ, Colburn, CA, Moore, MC, Neal, DW, Dominianni, SJ, Stephens, TW, Cherrington, AD. Regulation of net hepatic substrate balance by phenacylimidazolium ions in the conscious dog. Diabetes Res, 22(3), 123-33, 1993.

Adkins-Marshall, B, Pagliassotti, MJ, Asher, JR, Connolly, CC, Neal, DW, Williams, PE, Myers, SR, Hendrick, GK, Adkins, RB, Cherrington, AD. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol, 262(5 Pt 1), E679-86, 1992.

Connolly, CC, Adkins-Marshall, BA, Neal, DW, Pugh, W, Jaspan, JB, Cherrington, AD. Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Diabetes, 41(10), 1308-19, 1992.

Davis, SN, Dobbins, R, Tarumi, C, Colburn, C, Neal, D, Cherrington, AD. Effects of differing insulin levels on response to equivalent hypoglycemia in conscious dogs. Am J Physiol, 263(4 Pt 1), E688-95, 1992.

Goldstein, RE, Reed, GW, Wasserman, DH, Williams, PE, Lacy, DB, Buckspan, R, Abumrad, NN, Cherrington, AD. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metabolism, 41(12), 1295-303, 1992.

Hendrick, GK, Wasserman, DH, Frizzell, RT, Williams, PE, Lacy, DB, Jaspan, JB, Cherrington, AD. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am J Physiol, 263(3 Pt 1), E541-9, 1992.

Pagliassotti, MJ, Cherrington, AD. Regulation of net hepatic glucose uptake in vivo. Annu Rev Physiol, 54, 847-60, 1992.

Pagliassotti, MJ, Moore, MC, Neal, DW, Cherrington, AD. Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog. Diabetes, 41(10), 1247-56, 1992.

Cherrington, AD, Frizzell, RT, Biggers, DW, Connolly, CC. Hypoglycemia, gluconeogenesis and the brain. Adv Exp Med Biol, 291, 197-211, 1991.

Cherrington, AD, Pagliassotti, MJ, Myers, SR, Adkins-Marshall, B, McGuinness, OP. Factors which regulate net hepatic glucose uptake in vivo. JPEN J Parenter Enteral Nutr, 15(3), 71S-73S, 1991.

Connolly, CC, Steiner, KE, Stevenson, RW, Neal, DW, Williams, PE, Alberti, KG, Cherrington, AD. Regulation of glucose metabolism by norepinephrine in conscious dogs. Am J Physiol, 261(6 Pt 1), E764-72, 1991.

Connolly, CC, Steiner, KE, Stevenson, RW, Neal, DW, Williams, PE, Alberti, KG, Cherrington, AD. Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Am J Physiol, 261(4 Pt 1), E466-72, 1991.

Dobbins, RL, Connolly, CC, Neal, DW, Palladino, LJ, Parlow, AF, Cherrington, AD. Role of glucagon in countering hypoglycemia induced by insulin infusion in dogs. Am J Physiol, 261(6 Pt 1), E773-81, 1991.

Frizzell, RT, Meyer, YJ, Borchers, DJ, Weprin, BE, Allen, EC, Pogue, WR, Reisch, JS, Cherrington, AD, Batjer, HH. The effects of etomidate on cerebral metabolism and blood flow in a canine model for hypoperfusion. J Neurosurg, 74(2), 263-9, 1991.

Moore, MC, Cherrington, AD, Cline, G, Pagliassotti, MJ, Jones, EM, Neal, DW, Badet, C, Shulman, GI. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest, 88(2), 578-87, 1991. PMCID:295390

Myers, SR, Biggers, DW, Neal, DW, Cherrington, AD. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest, 88(1), 158-67, 1991. PMCID:296016

Myers, SR, Diamond, MP, Adkins-Marshall, BA, Williams, PE, Stinsen, R, Cherrington, AD. Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metabolism, 40(1), 66-71, 1991.

Myers, SR, McGuinness, OP, Neal, DW, Cherrington, AD. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest, 87(3), 930-9, 1991. PMCID:329884

Pagliassotti, MJ, Myers, SR, Moore, MC, Neal, DW, Cherrington, AD. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes, 40(12), 1659-68, 1991.

Pagliassotti, MJ, Tarumi, C, Neal, DW, Cherrington, AD. Hepatic denervation alters the disposition of an enteral glucose load in conscious dogs. J Nutr, 121(8), 1255-61, 1991.

Steiner, KE, Stevenson, RW, Adkins-Marshall, BA, Cherrington, AD. The effects of epinephrine on ketogenesis in the dog after a prolonged fast. Metabolism, 40(10), 1057-62, 1991.

Stevenson, RW, Steiner, KE, Connolly, CC, Fuchs, H, Alberti, KG, Williams, PE, Cherrington, AD. Dose-related effects of epinephrine on glucose production in conscious dogs. Am J Physiol, 260(3 Pt 1), E363-70, 1991.

Wasserman, DH, Cherrington, AD. Hepatic fuel metabolism during muscular work: role and regulation. Am J Physiol, 260(6 Pt 1), E811-24, 1991.

Wasserman, DH, Lacy, DB, Colburn, CA, Bracy, D, Cherrington, AD. Efficiency of compensation for absence of fall in insulin during exercise. Am J Physiol, 261(5 Pt 1), E587-97, 1991.

Adkins-Marshall, BA, Myers, SR, Hendrick, GK, Williams, PE, Triebwasser, K, Floyd, B, Cherrington, AD. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes, 39(1), 87-95, 1990.

Hendrick, GK, Frizzell, RT, Williams, PE, Cherrington, AD. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am J Physiol, 258(5 Pt 1), E841-9, 1990.

McGuinness OP; discussion 51S-53S, , Cherrington, AD. Effect of glyburide on hepatic glucose metabolism. Am J Med, 89(2A), 26S-37S, 1990.

McGuinness, OP, Friedman, A, Cherrington, AD. Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog. Metabolism, 39(2), 127-32, 1990.

McGuinness, OP, Myers, SR, Neal, D, Cherrington, AD. Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity. Metabolism, 39(9), 931-7, 1990.

Steiner, KE, Williams, PE, Lacy, WW, Cherrington, AD. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Metabolism, 39(12), 1325-33, 1990.

Wasserman, DH, Williams, PE, Lacy, DB, Bracy, D, Cherrington, AD. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am J Physiol, 259(2 Pt 1), E195-203, 1990.

Biggers, DW, Myers, SR, Neal, D, Stinson, R, Cooper, NB, Jaspan, JB, Williams, PE, Cherrington, AD, Frizzell, RT. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes, 38(1), 7-16, 1989.

Cryer, PE, Binder, C, Bolli, GB, Cherrington, AD, Gale, EA, Gerich, JE, Sherwin, RS. Hypoglycemia in IDDM. Diabetes, 38(9), 1193-9, 1989.

Wasserman, DH, Lacy, DB, Goldstein, RE, Williams, PE, Cherrington, AD. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes, 38(4), 484-90, 1989.

Wasserman, DH, Spalding, JA, Bracy, D, Lacy, DB, Cherrington, AD. Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Diabetes, 38(6), 799-807, 1989.

Wasserman, DH, Spalding, JA, Lacy, DB, Colburn, CA, Goldstein, RE, Cherrington, AD. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol, 257(1 Pt 1), E108-17, 1989.

Wasserman, DH, Williams, PE, Lacy, DB, Goldstein, RE, Cherrington, AD. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am J Physiol, 256(4 Pt 1), E500-9, 1989.

Diamond, MP, Rollings, RC, Steiner, KE, Williams, PE, Lacy, WW, Cherrington, AD. Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Metabolism, 37(1), 28-33, 1988.

Diamond, MP, Wentz, AC, Cherrington, AD. Alterations in carbohydrate metabolism as they apply to reproductive endocrinology. Fertil Steril, 50(3), 387-97, 1988.

Frizzell, RT, Campbell, PJ, Cherrington, AD. Gluconeogenesis and hypoglycemia. Diabetes Metab Rev, 4(1), 51-70, 1988.

Frizzell, RT, Hendrick, GK, Biggers, DW, Lacy, DB, Donahue, DP, Green, DR, Carr, RK, Williams, PE, Stevenson, RW, Cherrington, AD. Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes, 37(6), 749-59, 1988.

Frizzell, RT, Hendrick, GK, Brown, LL, Lacy, DB, Donahue, EP, Carr, RK, Williams, PE, Parlow, AF, Stevenson, RW, Cherrington, AD. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes, 37(11), 1531-41, 1988.

Moates, JM, Lacy, DB, Goldstein, RE, Cherrington, AD, Wasserman, DH. Metabolic role of the exercise-induced increment in epinephrine in the dog. Am J Physiol, 255(4 Pt 1), E428-36, 1988.

Stevenson, RW, Stebbing, N, Jones, T, Carr, K, Jones, PM, Hii, C, Cherrington, AD. The synthetic human growth hormone fragment (32-38) increases glucose uptake in the conscious dog. Acta Endocrinol (Copenh), 117(4), 457-62, 1988.

Wasserman, DH, Williams, PE, Lacy, DB, Green, DR, Cherrington, AD. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am J Physiol, 254(4 Pt 1), E518-25, 1988.

Adkins, BA, Myers, SR, Hendrick, GK, Stevenson, RW, Williams, PE, Cherrington, AD. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest, 79(2), 557-65, 1987. PMCID:424126

Cherrington, AD, Stevenson, RW, Steiner, KE. Glucagon as a regulator of hepatic glucose production in vivo. Biochem Soc Trans, 15(6), 1023-7, 1987.

Cherrington, AD, Stevenson, RW, Steiner, KE, Davis, MA, Myers, SR, Adkins, BA, Abumrad, NN, Williams, PE. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev, 3(1), 307-32, 1987.

Cohen, RM, Licinio, J, Polonsky, KS, Galloway, JA, Frank, BH, Cherrington, AD, Rubenstein, AH. The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes. J Clin Endocrinol Metab, 64(3), 476-81, 1987.

Davis, MA, Williams, PE, Cherrington, AD. Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog. Metabolism, 36(9), 856-62, 1987.

Goldstein, R, Wasserman, D, Williams, PE, Lacy, BS, Carr, K, Cherrington, A, Abumrad, NN. Metabolic effects of epinephrine during chronic hypercortisolemia. Surgical Forum, 38, 1-4, 1987.

Hendrick, GK, Frizzell, RT, Cherrington, AD. Effect of somatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting. Am J Physiol, 253(4 Pt 1), E443-52, 1987.

McGuinness, OP, Green, DR, Cherrington, AD. Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output. Diabetes, 36(4), 472-6, 1987.

Stevenson, RW, Mitchell, DR, Hendrick, GK, Rainey, R, Cherrington, AD, Frizzell, RT. Lactate as substrate for glycogen resynthesis after exercise. J Appl Physiol, 62(6), 2237-40, 1987.

Stevenson, RW, Stebbing, N, Rudman, CG, Williams, PE, Cherrington, AD. The synthetic 32-46 fragment of human growth hormone increases insulin and glucagon levels in the conscious dog. Metabolism, 36(4), 400-4, 1987.

Stevenson, RW, Steiner, KE, Davis, MA, Hendrick, GK, Williams, PE, Lacy, WW, Brown, L, Donahue, P, Lacy, DB, Cherrington, AD. Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Diabetes, 36(3), 382-9, 1987.

Stevenson, RW, Steiner, KE, Hendrick, GK, Cherrington, AD. Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs. Am J Physiol, 253(4 Pt 1), E435-42, 1987.

Stevenson, RW, Steiner, KE, Williams, PE, Cherrington, AD. Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog. Metabolism, 36(5), 451-7, 1987.

Stevenson, RW, Williams, PE, Cherrington, AD. Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia, 30(10), 782-90, 1987.

Wasserman, DH, Lacy, DB, Green, DR, Williams, PE, Cherrington, AD. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J Appl Physiol, 63(6), 2411-7, 1987.

Goldstein, R, Steed, M, Williams, P, Abumrad, N, Cherrington, A. Catabolic effects of chronic hypercotisolemia during insulin deficiency. Surgical Forum, 37, 15-18, 1986.

Steiner, KE, Mouton, SM, Williams, PE, Lacy, WW, Cherrington, AD. Relative importance of first- and second-phase insulin secretion in glucose homeostasis in conscious dog. II. Effects on gluconeogenesis. Diabetes, 35(7), 776-84, 1986.

Davis, MA, Williams, PE, Cherrington, AD. Effect of glucagon on hepatic lactate metabolism in the conscious dog. Am J Physiol, 248(4 Pt 1), E463-70, 1985.

Pilkis, SJ, Regen, DM, Claus, TH, Cherrington, AD. Role of hepatic glycolysis and gluconeogenesis in glycogen synthesis. BioEssays, 2(6), 273-274, 1985.

Steiner, KE, Fuchs, H, Williams, PE, Stevenson, RW, Cherrington, AD, Alberti, KG. Regulation of ketogenesis by epinephrine and norepinephrine in the overnight-fasted, conscious dog. Diabetes, 34(5), 425-32, 1985.

Steiner, KE, Stevenson, RW, Green, DR, Cherrington, AD. Mechanism of epinephrine''s glycogenolytic effect in isolated canine hepatocytes. Metabolism, 34(11), 1020-3, 1985.

Stevenson, RW, Cherrington, AD, Steiner, KE. The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog. Horm Metab Res, 17(11), 551-3, 1985.

Bergenstal, RM, Cohen, RM, Lever, CE, Polonsky, K, Jaspan, J, Blix, P, Revers, R, Olefsky, JM, Kolterman, O, Steiner, K, Cherrington, A, Frank, B, Galloway, J, Rubenstein, AH. The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. J Clin Endo Meta, 56(6), 973-979, 1984.

Cherrington, AD, Fuchs, H, Stevenson, RW, Williams, PE, Alberti, KG, Steiner, KE. Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs. Am J Physiol, 247(2 Pt 1), E137-44, 1984.

Davis, MA, Williams, PE, Cherrington, AD. Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am J Physiol, 247(3 Pt 1), E362-9, 1984.

Radosevich, PM, Williams, PE, Lacy, DB, McRae, JR, Steiner, KE, Cherrington, AD, Lacy, WW, Abumrad, NN. Effects of morphine on glucose homeostasis in the conscious dog. J Clin Invest, 74(4), 1473-80, 1984. PMCID:425317

Stevenson, RW, Steiner, KE, Green, DR, Cherrington, AD. Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes. Biochim Biophys Acta, 804(4), 414-8, 1984.

Cherrington, AD, Lacy, WW, Williams, PE, Steiner, KE. Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog. Am J Physiol, 244(6), E596-602, 1983.

Abumrad, NN, Cherrington, AD, Williams, PE, Lacy, WW, Rabin, D. Absorption and disposition of a glucose load in the conscious dog. Am J Physiol, 242(6), E398-406, 1982.

Abumrad, NN, Jefferson, LS, Rannels, SR, Williams, PE, Cherrington, AD, Lacy, WW. Role of insulin in the regulation of leucine kinetics in the conscious dog. J Clin Invest, 70(5), 1031-41, 1982. PMCID:370315

Cherrington, AD, Diamond, MP, Green, DR, Williams, PE. Evidence for an intrahepatic contribution to the waning effect of glucagon on glucose production in the conscious dog. Diabetes, 31(10), 917-22, 1982.

Cherrington, AD, Steiner, KE. The effects of insulin on carbohydrate metabolism in vivo. Clin Endocrinol Metab, 11(2), 307-28, 1982.

Cherrington, AD, Williams, PE, Abou-Mourad, N, Lacy, WW, Steiner, KE, Liljenquist, JE. Insulin as a mediator of hepatic glucose uptake in the conscious dog. Am J Physiol, 242(2), E97-101, 1982.

Diamond, MP, Suhrer, JH, Williams, PE, Cherrington, AD. Dichloroacetate: direct inhibitor of lipolysis in the conscious dog. Horm Metab Res, 14(2), 102-3, 1982.

Diamond, MP, Suhrer, JH, Williams, PE, Lacy, WW, Cherrington, AD. Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog. Diabetes, 31(4 Pt 1), 326-32, 1982.

Steiner, KE, Mouton, SM, Bowles, CR, Williams, PE, Cherrington, AD. The relative importance of first- and second-phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog. Diabetes, 31(11), 964-72, 1982.

Cherrington, AD, Williams, PE, Shulman, GI, Lacy, WW. Differential time course of glucagon''s effect on glycogenolysis and gluconeogenesis in the conscious dog. Diabetes, 30(3), 180-7, 1981.

Deri, JJ, Williams, PE, Steiner, KE, Cherrington, AD. Altered ability of the liver to produce glucose following a period of glucagon deficiency. Diabetes, 30(6), 490-5, 1981.

Diamond, MP, Williams, PE, Lacy, WW, Cherrington, AD. Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver. Metabolism, 30(9), 880-5, 1981.

Exton, JH, Blackmore, PF, El-Refai, MF, Dehaye, JP, Strickland, WG, Cherrington, AD, Chan, TM, Assimacopoulos-Jeannet, FD, Chrisman, TD. Mechanisms of hormonal regulation of liver metabolism. Adv Cyclic Nucleotide Res, 14, 491-505, 1981.

Liljenquist, JE, Lewis, SB, Cherrington, AD, Sinclair-Smith, BC, Lacy, WW. Effects of pharmacologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic man. Metabolism, 30(12), 1195-9, 1981.

Liljenquist, JE, Mueller, GL, Cherrington, AD, Perry, JM, Rabin, D. Retardant effect of hyperglycemia on the rise in plasma fatty acids following insulin withdrawal in man. Horm Metab Res, 13(10), 542-5, 1981.

Chiasson, JL, Atkinson, RL, Cherrington, AD, Keller, U, Sinclair-Smith, BC, Lacy, WW, Liljenquist, JE. Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man. Metabolism, 29(9), 810-8, 1980.

Diamond, MP, Rollings, RC, Erlendson, L, Williams, PE, Lacy, WW, Rabin, D, Cherrington, AD. Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog. Diabetes, 29(9), 702-9, 1980.

Shulman, GI, Lacy, WW, Liljenquist, JE, Keller, U, Williams, PE, Cherrington, AD. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest, 65(2), 496-505, 1980. PMCID:371388

Shulman, GI, Williams, PE, Liljenquist, JE, Lacy, WW, Keller, U, Cherrington, AD. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metabolism, 29(4), 317-20, 1980.

Wilson, FA, Antonson, DL, Hart, BL, Warr, TA, Cherrington, AD, Liljenquist, JE. The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology, 106(5), 1562-7, 1980.

Cherrington, AD, Liljenquist, JE, Shulman, GI, Williams, PE, Lacy, WW. Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. Am J Physiol, 236(3), E263-71, 1979.

Chiasson, JL, Atkinson, RL, Cherrington, AD, Keller, U, Sinclair-Smith, BC, Lacy, WW, Liljenquist, JE. Effects of fasting on gluconeogenesis from alanine in nondiabetic man. Diabetes, 28(1), 56-60, 1979.

Liljenquist, JE, Bloomgarden, ZT, Cherrington, AD, Perry, JM, Rabin, D. Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man. Diabetologia, 17(3), 139-43, 1979.

Liljenquist, JE, Mueller, GL, Cherrington, AD, Perry, JM, Rabinowitz, D. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endocrinol Metab, 48(1), 171-5, 1979.

Bloomgarden, ZT, Liljenquist, JE, Cherrington, AD, Rabinowitz, D. Persistent stimulatory effect of glucagon on glucose production despite downregulation. J Clin Endocrinol Metab, 47(5), 1152-5, 1978.

Cherrington, AD, Chiasson, JL, Liljenquist, JE, Lacy, WW, Park, CR. Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem Soc Symp, (43), 31-45, 1978.

Cherrington, AD, Lacy, WW, Chiasson, JL. Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest, 62(3), 664-77, 1978. PMCID:371813

Cherrington, AD, Williams, PE, Harris, MS. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism, 27(7), 787-91, 1978.

Exton, JH, Assimacopoulos-Jeannet, FD, Blackmore, PF, Cherrington, AD, Chan, TM. Mechanisms of catecholamine actions on liver carbohydrate metabolism. Adv Cyclic Nucleotide Res, 9, 441-52, 1978.

Keller, U, Cherrington, AD, Liljenquist, JE. Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs. Am J Physiol, 235(2), E238-47, 1978.

Shulman, GI, Liljenquist, JE, Williams, PE, Lacy, WW, Cherrington, AD. Glucose disposal during insulinopenia in somatostatin-treated dogs: The roles of glucose and glucagon. J Clin Invest, 62, 487-491, 1978.

Cherrington, AD, Caldwell, MD, Dietz, MR, Exton, JH, Crofford, OB. The effect of somatostatin on glucose uptake and production by rat tissues in vitro. Diabetes, 26(8), 740-8, 1977.

Cherrington, AD, Hundley, RF, Dolgin, S, Exton, JH. Studies of the role of beta-adrenergic receptors in the activation of phosphorylase in rat hepatocytes by catecholamines. J Cyclic Nucleotide Res, 3(4), 263-73, 1977.

Chiasson, JL, Liljenquist, JE, Lacy, WW, Jennings, AS, Cherrington, AD. Gluconeogenesis: methodological approaches in vivo. Fed Proc, 36(2), 229-35, 1977.

Jennings, AS, Cherrington, AD, Liljenquist, JE, Keller, U, Lacy, WW, Chiasson, JL. The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes, 26(9), 847-56, 1977.

Keller, U, Chiasson, JL, Liljenquist, JE, Cherrington, AD, Jennings, AS, Crofford, OS. The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Diabetes, 26(11), 1040-51, 1977.

Liljenquist, JE, Mueller, GL, Cherrington, AD, Keller, U, Chiasson J-L, , Perry, JM, Lacy, WW, Rabinowitz, D. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest, 59(2), 369-74, 1977. PMCID:333368

Cherrington, AD, Assimacopoulos, FD, Harper, SC, Corbin, JD, Park, CR, Exton, JH. Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3'':5''-monophosphate and adenosine 3'':5''-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes. J Biol Chem, 251(17), 5209-18, 1976.

Cherrington, AD, Chiasson, JL, Liljenquist, JE, Jennings, AS, Keller, U, Lacy, WW. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest, 58(6), 1407-18, 1976. PMCID:333312

Cherrington, AD, Exton, JH. Studies on the role of cAMP-dependent protein kinase in the actions of glucagon and catecholamines on liver glycogen metabolism. Metabolism, 25(11 Suppl 1), 1351-4, 1976.

Liljenquist, JE, Chiassan, JL, Cherrington, AD, Keller, U, Jennings, AS, Bomboy, JD, Lacy, WW. An important role for glucagon in the regulation of glucose production in vivo. Metabolism, 25(11 Suppl 1), 1371-3, 1976.

Cherrington, AD, Kawamori, R, Pek, S, Vranic, M. Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Diabetes, 23(10), 805-15, 1974.

Cherrington, AD, Vranic, M. Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Metabolism, 23(8), 729-44, 1974.

Cherrington, AD, Vranic, M. Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Diabetes, 22(7), 537-43, 1973.

Cherrington, A, Vranic, M, Fono, P, Kovacevic, N. Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions. Can J Physiol Pharmacol, 50(10), 946-54, 1972.

Cherrington, A, Vranic, M. Role of glucagon and insulin in control of glucose turnover. Metabolism, 20(6), 625-8, 1971.

Cherrington, AD, Paim, U, Page, OT. In vitro degradation of DDT by intestinal contents of Atlantic salmon (Salmo salar). J Fish Res Bd Can, 26, 47-54, 1969.

Van Petten, GR, Hirsch, GH, Cherrington, AD. Drug-metabolizing activity of the human placenta. Can J Biochem, 46(9), 1057-61, 1968.


Postdoctoral Position Available
no

Postdoctoral Position Details
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Updated Date
08/27/2008