Vanderbilt University School of Medicine

Davidson, Jeffrey M. , Ph.D.
Professor of Pathology, Microbiology and Immunology

Lab Url: http://medschool.mc.vanderbilt.edu/pathology/php_file/show_partpathology.php?id3=754

Phone Number: 615-327-4751 ext. 5488

Email Address:jeff.davidson@vanderbilt.edu

Davidson, Jeffrey's picture

Office Address   Mailing Address

F527 ACRE, VA Medical Center

C-3321A MCN 37232-2562


Research Specialty
Connective tissue research; Wound healing; Gene therapy

Research Description
Elastin is a highly insoluble matrix protein with very low turnover. We study elastin gene expression in several biological systems. cDNA and antibody probes are used, respectively, to study regulation of elastin mRNA and protein synthesis, particularly related to modulation of elastin metabolism in diseases of human connective tissues such as blood vessels, lung and skin. Transcriptional and post-transcriptional regulation of matrix synthesis is evident in this system The role of mRNA stability, cis-acting mutations, and trans-acting factors are being evaluated in the context of elastic tissue diseases and growth factor responses. Cytokine effects are tested on cells from vascular smooth muscle, skin, and vocal fold. Several human diseases involve loss or excessive accumulation of elastic tissue, including an unusual aging syndrome, Hutchinson-Gilford progeria, and recessive and acquired forms of cutis laxa.. The consequences of elastin mutations that we discovered in cutis laxa is under intense examination

Connective tissue production and remodeling are also critical to proper wound repair. We have been examining the mechanisms of collagen and elastin turnover in pulmonary fibrosis and related diseases. We also use animal models to explore how addition or local inactivation of growth factors such as basic fibroblast growth factor, keratinocyte growth factor, transforming growth factor-? superfamily members, platelet derived growth factor and connective tissue growth affect the process and outcome of wound healing. Defective wound healing is an important clinical problem that is under study in fibrotic, aging and diabetic animal populations. Cellular and tissue-equivalent models are used where they appear to accurately reflect tissue behavior. Evaluation of gene expression by in situ and filter hybridization reveals diverse mechanisms, including the influence of metalloproteinases involved in reorganization of fibrous connective tissue.

We have used a novel form of gene therapy to express various factors in wounds with clear effects on the rate of healing. This technique offers the possibility of manipulating the healing process in a new and precise way, since recombinant expression vectors can be readily modified to understand structure-function relationships in an authentic biological context. Gene therapy of wounds also offers a rapid way to screen for wound healing functions of newly discovered cDNAs.

The laboratory is also part of the Vanderbilt Free-Electron Laser Center. This is a multidisciplinary program in which this laboratory is examining how tissues respond and heal after irradiation from the most powerful source of pulsed, infrared light energy in the country. .

Publications
Caldwell, RL, Opalenik, SR, Davidson, JM, Caprioli, RM, Nanney, LB. Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds. Wound Repair Regen, 16(3), 442-9, 2008.

Davidson, JM. First-class delivery: getting growth factors to their destination. J Invest Dermatol, 128(6), 1360-2, 2008.

Hafeman, AE, Li, B, Yoshii, T, Zienkiewicz, K, Davidson, JM, Guelcher, SA. Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration. Pharm Res, , , 2008.

Prokop, A, Davidson, JM. Nanovehicular intracellular delivery systems. J Pharm Sci, 97(9), 3518-90, 2008.

Wilmink, GJ, Opalenik, SR, Beckham, JT, Abraham, AA, Nanney, LB, Mahadevan-Jansen, A, Davidson, JM, Jansen, ED. Molecular Imaging-Assisted Optimization of Hsp70 Expression during Laser-Induced Thermal Preconditioning for Wound Repair Enhancement. J Invest Dermatol, , , 2008.

Caldwell, RL, Opalenik, SR, Davidson, JM, Caprioli, RM, Nanney, LB. Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds. Wound Repair Regen, , , 2007.

Hartig, SM, Carlesso, G, Davidson, JM, Prokop, A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules, 8(1), 265-72, 2007.

Hartig, SM, Greene, RR, Carlesso, G, Higginbotham, JN, Khan, WN, Prokop, A, Davidson, JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials, 28(26), 3843-55, 2007. PMCID:2000344

Rauth, TP, Poulose, BK, Davidson, JM, Nanney, LB, Holzman, MD. Mechanical abrasion improves early incorporation of small intestinal submucosa. Am Surg, 73(7), 647-51; discussion 651, 2007.

Davidson, JM, Giro, M. Healing slack skin. J Invest Dermatol, 126(12), 2563-4, 2006.

Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM. Novel approaches for understanding the mechanisms of wound repair. J Investig Dermatol Symp Proc, 11(1), 132-9, 2006.

Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM. Novel approaches for understanding the mechanisms of wound repair. J Invest Dermatol, 126 Suppl, 132-9, 2006.

Samaras, SE, Shi, Y, Davidson, JM. CARP: Fishing for Novel Mechanisms of Neovascularization. J Invest Dermatol, 126 Suppl, 124-31, 2006.

Samaras, SE, Shi, Y, Davidson, JM. CARP: fishing for novel mechanisms of neovascularization. J Investig Dermatol Symp Proc, 11(1), 124-31, 2006.

Spindler, KP, Murray, MM, Devin, C, Nanney, LB, Davidson, JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res, 24(3), 401-406, 2006.

Tang, T, Shi, Y, Opalenik, SR, Brantley-Sieders, DM, Chen, J, Davidson, JM, Brandt, SJ. Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes. J Pathol, 210(1), 121-9, 2006.

Wilmink, GJ, Opalenik, SR, Beckham, JT, Davidson, JM, Jansen, ED. Assessing laser-tissue damage with bioluminescent imaging. J Biomed Opt, 11(4), 041114, 2006.

Carlesso, G, Kozlov, E, Prokop, A, Unutmaz, D, Davidson, JM. Nanoparticulate system for efficient gene transfer into refractory cell targets. Biomacromolecules, 6(3), 1185-92, 2005.

Opalenik, SR, Davidson, JM. Fibroblast differentiation of bone marrow-derived cells during wound repair. FASEB J, 19(11), 1561-3, 2005.

Shi, Y, Reitmaier, B, Regenbogen, J, Slowey, RM, Opalenik, SR, Wolf, E, Goppelt, A, Davidson, JM. CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. Am J Pathol, 166(1), 303-12, 2005. PMCID:1602297

Wu, N, Davidson, JM. Migration inhibitory factor-related protein (MRP)8 and MRP14 are differentially expressed in free-electron laser and scalpel incisions. Wound Repair Regen, 12(3), 327-36, 2004.

Davidson, Jeffrey M, Breyer, Matthew D. Inflammatory modulation and wound repair. J Invest Dermatol, 120(5), xi-xii, 2003.

Davidson, Jeffrey M, Eming, Sabine A, Dasgupta, Jayasri. Particle-mediated gene therapy of wounds. Methods Mol Med, 78, 433-52, 2003.

Ma, Li-Jun, Yang, Haichun, Gaspert, Ariana, Carlesso, Gianluca, Barty, Melissa M, Davidson, Jeffrey M, Sheppard, Dean, Fogo, Agnes B. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol, 163(4), 1261-73, 2003. PMCID:1868298

Riordan, Colin L, McDonough, Mark, Davidson, Jeffrey M, Corley, Randall, Perlov, Cathy, Barton, Ronald, Guy, Jeffrey, Nanney, Lillian B. Noncontact laser Doppler imaging in burn depth analysis of the extremities. J Burn Care Rehabil, 24(4), 177-86, 2003.

Spindler, Kurt P, Murray, Martha M, Detwiler, Kenneth B, Tarter, Jeremy T, Dawson, John M, Nanney, Lillian B, Davidson, Jeffrey M. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res, 21(2), 245-9, 2003.

Wu, Nanjun, Jansen, E Duco, Davidson, Jeffrey M. Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing. J Invest Dermatol, 121(4), 926-32, 2003.

Prokop, A., Kozlov, E., Moore, W. Davidson , J.M. Maximizing the in vivo efficiency of gene transfer by means of non-viral polymeric gene delivery vehicles. J Pharmaceut Sci, in press

Davidson, Jeffrey M. Smad about elastin regulation. Am J Respir Cell Mol Biol, 26(2), 164-6, 2002.

Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B, Davidson, Jeffrey M, Linton, MacRae F, Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest, 110(12), 1859-68, 2002. PMCID:151648

Prokop, Ales, Kozlov, Evgenii, Moore, William, Davidson, Jeffrey M. Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles. J Pharm Sci, 91(1), 67-76, 2002.

Spindler, K P, Dawson, J M, Stahlman, G C, Davidson, J M, Nanney, L B. Collagen expression and biomechanical response to human recombinant transforming growth factor beta (rhTGF-beta2) in the healing rabbit MCL. J Orthop Res, 20(2), 318-24, 2002.

Wu, Nanjun, Opalenik, Susan, Liu, Jinhua, Jansen, E Duco, Giro, Maria Gabriella, Davidson, Jeffrey M. Real-time visualization of MMP-13 promoter activity in transgenic mice. Matrix Biol, 21(2), 149-61, 2002.

Ballas, C B, Davidson, J M. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Repair Regen, 9(3), 223-37, 2001.

Ballas, C.B., Davidson, J.M. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Rep. Regen, 9, 223-227, 2001.

Bennett, L L, Rosenblum, R S, Perlov, C, Davidson, J M, Barton, R M, Nanney, L B. An in vivo comparison of topical agents on wound repair. Plast Reconstr Surg, 108(3), 675-87, 2001.

Davidson, J M, Krieg, T, Eming, S A. Particle-mediated gene therapy of wounds. Wound Repair Regen, 8(6), 452-9, 2001.

Davidson, J.M. Experimental animal wound models. Wounds, 13, 9-23, 2001.

Drew, A.F., Liu, H., Davidson, J.M., Daugherty, C.C., Degen, J.L. Wound healing defects in mice lacking fibrinogen. Blood, 97, 3691-98, 2001.

Nanney LB, Wamil BD, Whitsitt J, Cardwell JL, Davidson JM, Yan, H.P., Hellerqvist CG. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis, 4, 61-70, 2001.

Nanney, L B, Wamil, B D, Whitsitt, J, Cardwell, N L, Davidson, J M, Yan, H P, Hellerqvist, C G. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis, 4(1), 61-70, 2001.

Prokop, A, Kozlov, E, Nun Non, S, Dikov, M M, Sephel, G C, Whitsitt, J S, Davidson, J M. Towards retrievable vascularized bioartificial pancreas: induction and long-lasting stability of polymeric mesh implant vascularized with the help of acidic and basic fibroblast growth factors and hydrogel coating. Diabetes Technol Ther, 3(2), 245-61, 2001.

Prokop, A., Kozlov, E., Nun Non, Shuhaida, Dikov, M.M., Sephel, G.C., Davidson, J.M. Towards retrievable vascularized bioartificial pancreas (vbap): induction and long-lasting stability of polymeric mesh implant vascularized with help of acidic and basic fibroblast growth factors and hydrogel coating. Diab Technol Therap, 3, 245-261, 2001.

Light, R.W., Cheng, D-S., Lee, Y.C., Rogers, J., Davidson, J.M., Lane, K.B. A single intrapleural injection of transforming growth factor ?2 produces an excellent pleurodesis in rats. Am J Respir Crit Care Med., 162, 98-104, 2000.

Ma, L J, Nakamura, S, Whitsitt, J S, Marcantoni, C, Davidson, J M, Fogo, A B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int, 58(6), 2425-36, 2000.

Ma, L.-J., Nakamura, S., Whitsitt, J.S., Marcantoni, C., Davidson, J.M., Fogo, A.B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int., 56, 2425-2436, 2000.

Nanney, L B, Paulsen, S, Davidson, M K, Cardwell, N L, Whitsitt, J S, Davidson, J M. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen, 8(2), 117-27, 2000.

Nanney, L.B., Paulsen, S., Davidson, M.K., Cardwell, N.L., Whitsitt, J.S., Davidson, J.M. Boosting EGF receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Rep. Reg, 8, 117-127, 2000.

Davidson, J M, Aquino, A M, Woodward, S C, Wilfinger, W W. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J, 13(2), 325-9, 1999.

Davidson, J M, Whitsitt, J S, Pennington, B, Ballas, C B, Eming, S, Benn, S I. Gene therapy of wounds with growth factors. Curr Top Pathol, 93, 111-21, 1999.

Davidson, J.M., Aquino, A.M., Woodward, S.C., Wilfinger, W.W. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J, 13, 325-329, 1999.

Eming, S.A., Whitsitt, J.S., He, L., Krieg, T., Morgan, J.R., Davidson, J.M. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J. Invest. Dermatol, 112, 297-302, 1999.

Garrard, C L, Clements, R H, Nanney, L, Davidson, J M, Richards, W O. Adhesion formation is reduced after laparoscopic surgery. Surg Endosc, 13(1), 10-3, 1999.

Hoff, C R, Perkins, D R, Davidson, J M. Elastin gene expression is upregulated during pulmonary fibrosis. Connect Tissue Res, 40(2), 145-53, 1999.

Hoff, C.R. and Davidson, J.M. Elastin expression in murine pulmonary fibrosis. Connect. Tiss. Res, 40, 145-153, 1999.

Zhang, M C, He, L, Giro, M, Yong, S L, Tiller, G E, Davidson, J M. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). J Biol Chem, 274(2), 981-6, 1999.

Zhang, M.C., He L., Giro M, Yong S-L, Tiller G.E., and Davidson J.M . Cutis laxa arising from frame shift mutations in the elastin gene (ELN). J. Biol. Chem, 274, 981-986, 1999.

Bryant, G L, Davidson, J M, Ossoff, R H, Garrett, C G, Reinisch, L. Histologic study of oral mucosa wound healing: a comparison of a 6.0- to 6.8-micrometer pulsed laser and a carbon dioxide laser. Laryngoscope, 108(1 Pt 1), 13-7, 1998.

Bryant, G.L., Davidson, J.M., Ossoff, R.H., Garrett, G. and Reinisch, L. Histologic study of oral mucosa wound healing: A comparison of a 6.0- to 6.8-?m pulsed laser and a carbon dioxide laser. Laryngoscope, 108, 13-17, 1998.

Davidson, J M. Animal models for wound repair. Arch Dermatol Res, 290 Suppl, S1-11, 1998.

Davidson, J M. Wound repair. J Hand Ther, 11(2), 80-94, 1998.

Davidson, J.M. Animal models for wound repair. Arch. Dermatol Res, 290, S1-S11, 1998.

Liaw, L, Birk, D E, Ballas, C B, Whitsitt, J S, Davidson, J M, Hogan, B L. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest, 101(7), 1468-78, 1998. PMCID:508725

Liaw, L., Birk, D.E., Whitsitt, J.S., Ballas, C.B., Davidson, J.M., Hogan, B.L.M. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J. Clin. Invest., 101, 1468-1478, 1998.

Davidson, J M, LuValle, P A, Zoia, O, Quaglino, D, Giro, M. Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J Biol Chem, 272(1), 345-52, 1997.

Davidson, J.M., Broadley, K.N., Quaglino Jr., D. Reversal of the wound healing deficit in diabetic rats by combined basic fibroblast growth factor and transforming growth factor-? therapy. Wound Rep. Regen, 5, 77-88, 1997.

Davidson, J.M., LuValle, P.A., Zoia, O., Quaglino, Jr., D., Giro, M.G. Ascorbate down regulates collagen and elastin biosynthesis in vascular smooth muscle cells and skin fibroblasts by a pretranslational mechanism. J. Biol. Chem, 272, 345-352, 1997.

Benn, S I, Whitsitt, J S, Broadley, K N, Nanney, L B, Perkins, D, He, L, Patel, M, Morgan, J R, Swain, W F, Davidson, J M. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J Clin Invest, 98(12), 2894-902, 1996. PMCID:507757

Benn, S.I., Whitsitt, J.S., Broadley, K.N., He, L.,Nanney, L.B., Perkins, D, Patel, M., Swain, W.F.,Davidson, J.M. Particle mediated gene transfer with TGF-?1 cDNAs enhances wound repair in rat skin. J. Clin. Invest., 98(12), 2894-2902, 1996.

Charous, S.J., Ossoff, R.H., Davidson, J.M. Canine subglottic stenosis as a model for hypertrophic scarring: histological and immunochemical analysis. Wound Repair Regen, 4, 444-453, 1996.

Charous, SJ, Ossoff, RH, Reinisch, L, Davidson, JM. Canine subglottic stenosis as a model for excessive fibrosis: a pilot histologic and immunohistochemical analysis. Wound Repair Regen, 4(4), 444-53, 1996.

Clymer, M A, Schwaber, M K, Davidson, J M. The effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope, 106(3 Pt 1), 280-5, 1996.

Clymer, M., Reinisch, L., Ossoff, R., Davidson, J.M. Effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope, 106, 280-285, 1996.

McCarthy, M.J., Davidson, J.M., Cardone, J.S., Anderson, L.L. Cutis laxa aquisita associated with multiple myeloma: A case report and review of the literature. Cutis, 57(4), 267-270, 1996.

Speyer, M, Joe, J, Davidson, J M, Ossoff, R H, Reinisch, L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions. Laryngoscope, 106(7), 845-50, 1996.

Speyer, M., Joe, J., Davidson, J.M., Ossoff, R.H., Reinisch, L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions . Laryngoscope, 106, 845-850, 1996.

Spindler, K P, Clark, S W, Nanney, L B, Davidson, J M. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J Orthop Res, 14(6), 857-61, 1996.

Spindler, K P, Imro, A K, Mayes, C E, Davidson, J M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J Orthop Res, 14(4), 542-6, 1996.

Spindler, K.P., Clark, S.W., Nanney, L.B., Davidson, J.M. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J. Orth. Res., 14, 857-861, 1996.

Spindler, K.P., Imro, A.K., Mayes, C.E., Davidson, J.M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor ?. J. Orth. Res., 14, 542-6, 1996.

Broadley, C, Broadley, KN, Disimone, G, Riensch, L, Davidson, JM. Low-energy helium-neon laser irradiation and the tensile strength of incisional wounds in the rat. Wound Repair Regen, 3(4), 512-7, 1995.

Broadley, C, Gonzalez, D A, Nair, R, Koriwchak, M J, Ossoff, R H, Davidson, J M. A tissue-culture model for the study of canine vocal fold fibroblasts. Laryngoscope, 105(1), 23-7, 1995.

Davidson, J M, Zang, M C, Zoia, O, Giro, M G. Regulation of elastin synthesis in pathological states. Ciba Found Symp, 192, 81-94; discussion 94-9, 1995.

Gossage, J R, Perkett, E A, Davidson, J M, Starcher, B C, Carmichael, D, Brigham, K L, Meyrick, B. Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep. J Appl Physiol, 79(4), 1163-72, 1995.

Spindler, K P, Mayes, C E, Miller, R R, Imro, A K, Davidson, J M. Regional mitogenic response of the meniscus to platelet-derived growth factor (PDGF-AB). J Orthop Res, 13(2), 201-7, 1995.

Spindler, KP, Nanney, LB, Davidson, JM. Proliferative responses to platelet-derived growth factor in young and old rat patellar tendon. Connect Tissue Res, 31(2), 171-7, 1995.

TGF-? reverses a post-transcriptional defect of elastin synthesis in two cutis laxa skin fibroblast strains. Zhang, M.C., Giro, M.G., Quaglino, D., Jr., Davidson, J.M. J. Clin. Invest, 95, 986-994, 1995.

Zhang, M C, Giro, M, Quaglino, D, Davidson, J M. Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain. J Clin Invest, 95(3), 986-94, 1995. PMCID:441431

Tissue ablation by a free-electron laser tuned to the amide II band. Edwards, G., Logan, R., Copeland, M., Reinisch, L., Davidson, J.M., Johnson, B., Maciunas, R., Mendenhall, M., Ossoff, R., Tribble, J., Werkhaven, J., O'Day, D. Nature, 371, 416-419, 1994.

Vrabec, J T, Schwaber, M K, Davidson, J M, Clymer, M A. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope, 104(9), 1059-64, 1994.

Giro, M, Davidson, J M. Familial co-segregation of the elastin phenotype in skin fibroblasts from Hutchinson-Gilford progeria. Mech Ageing Dev, 70(3), 163-36, 1993.

Gossage, J R, Kuratomi, Y, Davidson, J M, Lefferts, P L, Snapper, J R. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am Rev Respir Dis, 147(6 Pt 1), 1371-9, 1993.

Kyzer, M D, Aly, A S, Davidson, J M, Reinisch, L, Ossoff, R H. Sub ablation effects of the KTP laser on wound healing. Lasers Surg Med, 13(1), 62-71, 1993.

Giro, M G, Duvic, M, Smith, L T, Kennedy, R, Rapini, R, Arnett, F C, Davidson, J M. Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. J Invest Dermatol, 99(2), 129-37, 1992.

Lane, K B, Zoia, O, Davidson, J M. Semidry electrophoretic transfer of RNA to membranes. Biotechniques, 12(3), 340-2, 346, 1992.

Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R. Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 145(4 Pt 1), 762-6, 1992.

Davidson, J M, Broadley, K N. Manipulation of the wound-healing process with basic fibroblast growth factor. Ann N Y Acad Sci, 638, 306-15, 1991.

Davidson, J M, Nanney, L B, Broadley, K N, Whitsett, J S, Aquino, A M, Beccaro, M, Rastrelli, A. Hyaluronate derivatives and their application to wound healing: preliminary observations. Clin Mater, 8(1-2), 171-7, 1991.

Fava, R A, Olsen, N J, Postlethwaite, A E, Broadley, K N, Davidson, J M, Nanney, L B, Lucas, C, Townes, A S. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med, 173(5), 1121-32, 1991. PMCID:2118851

Henderson, G S, Conary, J T, Davidson, J M, Stewart, S J, House, F S, McCurley, T L. A reliable method for northern blot analysis using synthetic oligonucleotide probes. Biotechniques, 10(2), 190-7, 1991.

Perkett, E A, Davidson, J M, Meyrick, B. Sequence of structural changes and elastin peptide release during vascular remodelling in sheep with chronic pulmonary hypertension induced by air embolization. Am J Pathol, 139(6), 1319-32, 1991. PMCID:1886467

Quaglino, D, Nanney, L B, Ditesheim, J A, Davidson, J M. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model. J Invest Dermatol, 97(1), 34-42, 1991.

Davidson, J M. Biochemistry and turnover of lung interstitium. Eur Respir J, 3(9), 1048-63, 1990.

Garcia, F U, Wojta, J, Broadley, K N, Davidson, J M, Hoover, R L. Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo. Am J Pathol, 136(5), 1125-35, 1990. PMCID:1877437

Quaglino, D, Nanney, L B, Kennedy, R, Davidson, J M. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model. Lab Invest, 63(3), 307-19, 1990.

Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M. The diabetic rat as an impaired wound healing model: stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor. Biotechnol Ther, 1(1), 55-68, 1989.

Broadley, K N, Aquino, A M, Woodward, S C, Buckley-Sturrock, A, Sato, Y, Rifkin, D B, Davidson, J M. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab Invest, 61(5), 571-5, 1989.

Buckley-Sturrock, A, Woodward, S C, Senior, R M, Griffin, G L, Klagsbrun, M, Davidson, J M. Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors. J Cell Physiol, 138(1), 70-8, 1989.

Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M. Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats. Int J Tissue React, 10(6), 345-53, 1988.

Liu, J M, Davidson, J M. The elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells. Biochem Biophys Res Commun, 154(3), 895-901, 1988.

McGee, G S, Davidson, J M, Buckley, A, Sommer, A, Woodward, S C, Aquino, A M, Barbour, R, Demetriou, A A. Recombinant basic fibroblast growth factor accelerates wound healing. J Surg Res, 45(1), 145-53, 1988.

Sephel, G C, Sturrock, A, Giro, M G, Davidson, J M. Increased elastin production by progeria skin fibroblasts is controlled by the steady-state levels of elastin mRNA. J Invest Dermatol, 90(5), 643-7, 1988.

Buckley, A, Davidson, J M, Kamerath, C D, Woodward, S C. Epidermal growth factor increases granulation tissue formation dose dependently. J Surg Res, 43(4), 322-8, 1987.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
01/06/2012



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