Vanderbilt University School of Medicine

Guzman, Raul J. , M.D.
Adjunct Associate Professor of Surgery

Lab Url: N/A

Phone Number: 615-343-2343

Email Address:raul.guzman@vanderbilt.edu

Guzman, Raul's picture

Office Address   Mailing Address

D-5237, MCN Bldg.

Division of Vascular Surgery D-5237, MCN 37232-5727


Research Keywords
Vascular Biology,arterial remodeling, bone morphogenetic proteins, matrix metalloprotienases, diabetic vascular disease,Diabetes

Research Description
Arteries undergo structural remodeling in response to numerous pathophysiologic stimuli including increased blood pressure, increased blood flow, and vessel wall injury. Bone Morphogenetic Proteins are members of the TGF-beta superfamily of extracellular signaling molecules. Their expression has previously been shown to be increased in end-stage atherosclerotic vessels.

Our laboratory focuses on the role of BMPs in pathologic arterial remodeling. We have recently demonstrated that BMP4 is induced by alterations in shear stress in vivo and in cultured vascular endothelial cells using a cone and plate system. We are now using our models to evaluate the kinetics, cellular origin, and tissue localization of BMPs in arterial samples during the remodeling process. We use the techniques of in-situ hybridization, immunofluorescence, northern and western blotting, and Boyden chamber analysis of SMC migration. Future studies will involve in-vitro techniques to understand the effects of BMP expression in arterial smooth muscle cells, and mouse models to understand the effects of over expressing or deleting specific BMP species in the arterial wall in-vivo.

Our ultimate goal is to develop a basic understanding of the role of BMPs in arterial remodeling and to design new therapeutic strategies to inhibit pathologic forms of arterial remodeling in patients with arterial disease.

Clinical Research Description
Our research focuses on the vascular changes that occur in patients with diabetes. We are interested in preventing the lower extremity vascular problems that leads to amputation. We use CT and MR to identify markers of arterial disese that could be used to identify patients at high risk for lower extremity amputation.

Clinical Interests
We are interested in the vascular changes that occur in patients with diabetes. We use CT and MR imaging techniques identify changes in the arteries and muscles of patients with diabetes.

Publications
Corriere, MA, Guzman, RJ. Method of cell transplantation promoting the organization of intraarterial thrombus. Perspect Vasc Surg Endovasc Ther, 18(2), 188-90, 2006.

Qin, X, Corriere, MA, Matrisian, LM, Guzman, RJ. Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler Thromb Vasc Biol, 26(7), 1510-6, 2006.

Smith, JJ, Passman, MA, Dattilo, JB, Guzman, RJ, Naslund, TC, Netterville, JL. Carotid body tumor resection: does the need for vascular reconstruction worsen outcome. Ann Vasc Surg, 20(4), 435-9, 2006.

Castaldo, ET, Williams, EH, Dattilo, J, Passman, M, Naslund, T, Guzman, RJ. Common femoral vein aneurysm simulating an inguinal hernia. Am Surg, 71(7), 591-4, 2005.

Corriere, MA, Guzman, RJ. True and false aneurysms of the femoral artery. Semin Vasc Surg, 18(4), 216-23, 2005.

Corriere, MA, Passman, MA, Guzman, RJ, Dattilo, JB, Naslund, TC. Comparison of bedside transabdominal duplex ultrasound versus contrast venography for inferior vena cava filter placement: what is the best imaging modality. Ann Vasc Surg, 19(2), 229-34, 2005.

Faulk, J, Dattilo, JB, Guzman, RJ, Naslund, TC, Passman, MA. Neoaortic reconstruction for aortic graft infection: need for endovascular adjunctive therapies. Ann Vasc Surg, 19(6), 774-81, 2005.

Passman, MA, Dattilo, JB, Guzman, RJ, Naslund, TC. Bedside placement of inferior vena cava filters by using transabdominal duplex ultrasonography and intravascular ultrasound imaging. J Vasc Surg, 42(5), 1027-32, 2005.

Corriere, MA, Feurer, ID, Becker, SY, Dattilo, JB, Passman, MA, Guzman, RJ, Naslund, TC. Endoleak following endovascular abdominal aortic aneurysm repair: implications for duration of screening. Ann Surg, 239(6), 800-5; discussion 805-7, 2004. PMCID:1356288

Corriere, MA, Passman, MA, Guzman, RJ, Dattilo, JB, Naslund, TC. Mega-aneurysmal degeneration of a saphenous vein graft following infrainguinal bypass. A case report. Vasc Endovascular Surg, 38(3), 267-71, 2004.

Corriere, MA, Passman, MA, Guzman, RJ, Dattilo, JB, Naslund, TC. Retrieving "nonretrievable" inferior vena caval Greenfield filters: a therapeutic option for filter malpositioning. Ann Vasc Surg, 18(6), 629-34, 2004.

Garrett, JV, Passman, MA, Guzman, RJ, Dattilo, JB, Naslund, TC. Expanding options for bedside placement of inferior vena cava filters with intravascular ultrasound when transabdominal duplex ultrasound imaging is inadequate. Ann Vasc Surg, 18(3), 329-34, 2004.

Conners, Michael S, Becker, Stacey, Guzman, Raul J, Passman, Marc A, Pierce, Rosanna, Kelly, Tina, Naslund, Thomas C. Duplex scan-directed placement of inferior vena cava filters: a five-year institutional experience. J Vasc Surg, 35(2), 286-91, 2002.

Eliason, Jonathan L, Guzman, Raul J, Passman, Marc A, Naslund, Thomas C. Infected endovascular graft secondary to coil embolization of endoleak: a demonstration of the importance of operative sterility. Ann Vasc Surg, 16(5), 562-5, 2002.

Eliason, Jonathan L, Netterville, James L, Guzman, Raul J, Passman, Marc A, Naslund, Thomas C. Skull base resection with cervical-to-petrous carotid artery bypass to facilitate repair of distal internal carotid artery lesions. Cardiovasc Surg, 10(1), 31-7, 2002.

Guzman, Raul J, Krystkowiak, Andrew, Zarins, Christopher K. Early and sustained medial cell activation after aortocaval fistula creation in mice. J Surg Res, 108(1), 112-21, 2002.

Eliason, J L, Passman, M A, Guzman, R J, Naslund, T C. Durability of percutaneous angioplasty and stent implantation for the treatment of abdominal aortic coarctation: a case report. Vasc Surg, 35(5), 397-401, 2001.

Passman, M A, Guzman, R J, Pierce, R, Naslund, T C. Impact of Medicare denials on noninvasive vascular diagnostic testing. J Vasc Surg, 34(5), 846-53, 2001.

Guzman, R.J., Abe, K., Zarins, C.K. Flow-induced arterial enlargement is inhibited by suppression of nitric oxide synthase activity in vivo. Surgery , 122, 273-280, 1997.

Harrell RL, Rajanayagam S, Guzman RJ, Hirschowitz EA, Crystal RG, Epstein SE, Finkel T. Inhibition of vascular smooth muscle proliferation by adenoviral-mediated gene transfer of cytosine deaminase. Circulation, 96(6), 621-627, 1997.

Epstein, S.E., Speir, E., Unger, E., Guzman, R.J., Finkel, T. Molecular mechanisms in restenosis. J. Amer Col Cardiol, 23, 1278-1288, 1994.

Guzman, R.J., Hirshowitz, E., Brody, S., Crystal, R.G., Epstein, S.E., Finkel, T. In-vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus mediated transfer of the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci USA , 91, 10732-10736, 1994.

Guzman, R.J., Lemarchand, P.L., Crystal, R.G., Epstein, S.E., Finkel, T. Efficient and selective adenovirus- mediated gene transfer into vascular neointima. Circulation, 88, 2838-2848, 1993.

Guzman, R.J., Lemarchand, P.L., Crystal, R.G., Epstein, S.E., Finkel, T. Efficient transfer into myocardium by direct injection of adenovirus vectors. Circ Research, 73, 1202-1207, 1993.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
12/24/2007



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