Vanderbilt University School of Medicine

Haines, Jonathan L. , Ph.D.

Lab Url:

Phone Number: (615) 343-5851


Haines, Jonathan's picture

Office Address   Mailing Address

519 Light Hall

519D Light Hall 0700

Research Keywords
Human Genetics | Neurodegenerative Disorders Complex Disease Computational Genetics,Genome,Genomics,Human Genetics,Mutation,Neuroscience,Polymorphism

Research Specialty
Gene Discovery in Complex Human Disease

Research Description
Our primary research interest is the localization and identification of genes involved in human disease. This is a necessary first step in dissecting the etiology and physiology of the disease process and serves to test the role of genes in the disease process. To achieve our goals, we use a combination of approaches adopted from the fields of genetics, computer science, and epidemiology. These include family (genetic linkage) studies, allelic association (primarily linkage disequilibrium) studies, and development and application of new computational methods. Thus we integrate molecular, computational, and statistical methods to map and identify the underlying genes.

Our ultimate goal is to apply our findings in the clinical setting and improve clinical diagnosis and treatment. We are actively working on Alzheimer disease, multiple sclerosis, Parkinson disease, autism, macular degeneration, and other complex diseases. Our gene discovery efforts are already focused on chromosomes 9 and 12 (Alzheimer disease), 19 (multiple scleorsis), 7 (autism), and 10 (macular degeneration. We are using also studying AMish populations to help discover additional genes in Alzheimer disease and Parkinson disease.

Canter, JA, Olson, LM, Spencer, K, Schnetz-Boutaud, N, Anderson, B, Hauser, MA, Schmidt, S, Postel, EA, Agarwal, A, Pericak-Vance, MA, Sternberg, P, Haines, JL. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS ONE, 3(5), e2091, 2008. PMCID:2330085

Darbar, D, Hardy, A, Haines, JL, Roden, DM. Prolonged signal-averaged P-wave duration as an intermediate phenotype for familial atrial fibrillation. J Am Coll Cardiol, 51(11), 1083-9, 2008. PMCID:2279191

Darbar, D, Kannankeril, PJ, Donahue, BS, Kucera, G, Stubblefield, T, Haines, JL, George, AL, Roden, DM. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation, 117(15), 1927-35, 2008. PMCID:2365761

Liang, X, Schnetz-Boutaud, N, Bartlett, J, Allen, MJ, Gwirtsman, H, Schmechel, DE, Carney, RM, Gilbert, JR, Pericak-Vance, MA, Haines, JL. No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. Ann Hum Genet, 72(Pt 1), 141-4, 2008.

Ryckman, KK, Jiang, L, Li, C, Bartlett, J, Haines, JL, Williams, SM. A prevalence-based association test for case-control studies. Genet Epidemiol, , , 2008.

Shibao, C, Garland, EM, Gamboa, A, Vnencak-Jones, CL, Van Woeltz, M, Haines, JL, Yu, C, Biaggioni, I. PRNP M129V homozygosity in multiple system atrophy vs. Parkinson''s disease. Clin Auton Res, 18(1), 13-9, 2008.

Spencer, KL, Hauser, MA, Olson, LM, Schmidt, S, Scott, WK, Gallins, P, Agarwal, A, Postel, EA, Pericak-Vance, MA, Haines, JL. Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. Hum Mol Genet, 17(7), 971-7, 2008.

Spencer, KL, Olson, LM, Anderson, BM, Schnetz-Boutaud, N, Scott, WK, Gallins, P, Agarwal, A, Postel, EA, Pericak-Vance, MA, Haines, JL. C3 R102G polymorphism increases risk of age-related macular degeneration. Hum Mol Genet, 17(12), 1821-4, 2008.

Thornton-Wells, TA, Moore, JH, Martin, ER, Pericak-Vance, MA, Haines, JL. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Genet Epidemiol, 32(3), 187-203, 2008.

Haines, JL, Pericak-Vance, MA. Rapid dissection of the genetic risk of age-related macular degeneration: achieving the promise of the genomic era. JAMA, 297(4), 401-2, 2007.

Haines, JL, Spencer, KM, Pericak-Vance, MA. Bringing the genetics of macular degeneration into focus. Proc Natl Acad Sci U S A, 104(43), 16725-6, 2007. PMCID:2040461

Hedera, P, Blair, MA, Andermann, E, Andermann, F, D''Agostino, D, Taylor, KA, Chahine, L, Pandolfo, M, Bradford, Y, Haines, JL, Abou-Khalil, B. Familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology, , , 2007.

Liang, X, Martin, ER, Schnetz-Boutaud, N, Bartlett, J, Anderson, B, Z??chner, S, Gwirtsman, H, Schmechel, D, Carney, R, Gilbert, JR, Pericak-Vance, MA, Haines, JL. Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease. Hum Mutat, 28(11), 1065-73, 2007.

Liang, X, Schnetz-Boutaud, N, Bartlett, J, Anderson, BM, Gwirtsman, H, Schmechel, D, Carney, R, Gilbert, JR, Pericak-Vance, MA, Haines, JL. Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease. Dement Geriatr Cogn Disord, 23(2), 126-32, 2007.

Liang, X, Trentham-Dietz, A, Titus-Ernstoff, L, Newcomb, PA, Welch, RA, Hutchinson, AA, Hampton, JM, Sutcliffe, CB, Haines, JL, Egan, KM. Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancer. Cancer Epidemiol Biomarkers Prev, 16(8), 1610-4, 2007.

McCauley, JL, Kenealy, SJ, Margulies, EH, Schnetz-Boutaud, N, Gregory, SG, Hauser, SL, Oksenberg, JR, Pericak-Vance, MA, Haines, JL, Mortlock, DP. SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. BMC Genomics, 8, 266, 2007. PMCID:1959193

Spencer, KL, Hauser, MA, Olson, LM, Schmidt, S, Scott, WK, Gallins, P, Agarwal, A, Postel, EA, Pericak-Vance, MA, Haines, JL. Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. Hum Mol Genet, 16(16), 1986-92, 2007.

Spencer, KL, Hauser, MA, Olson, LM, Schnetz-Boutaud, N, Scott, WK, Schmidt, S, Gallins, P, Agarwal, A, Postel, EA, Pericak-Vance, MA, Haines, JL. Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. Invest Ophthalmol Vis Sci, 48(9), 4277-83, 2007.

Abou-Khalil, B, Krei, L, Lazenby, B, Harris, PA, Haines, JL, Hedera, P. Familial genetic predisposition, epilepsy localization and antecedent febrile seizures. Epilepsy Res, , , 2006.

Hahs, DW, McCauley, JL, Crunk, AE, McFarland, LL, Gaskell, PC, Jiang, L, Slifer, SH, Vance, JM, Scott, WK, Welsh-Bohmer, KA, Johnson, SR, Jackson, CE, Pericak-Vance, MA, Haines, JL. A genome-wide linkage analysis of dementia in the Amish. Am J Med Genet B Neuropsychiatr Genet, 141(2), 160-6, 2006. PMCID:2613780

Haines, JL, Schnetz-Boutaud, N, Schmidt, S, Scott, WK, Agarwal, A, Postel, EA, Olson, L, Kenealy, SJ, Hauser, M, Gilbert, JR, Pericak-Vance, MA. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci, 47(1), 329-35, 2006.

Hedera, P, Ma, S, Blair, MA, Taylor, KA, Hamati, A, Bradford, Y, Abou-Khalil, B, Haines, JL. Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22. Epilepsia, 47(10), 1622-8, 2006.

Kallianpur, AR, Hulgan, T, Canter, JA, Ritchie, MD, Haines, JL, Robbins, GK, Shafer, RW, Clifford, DB, Haas, DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. AIDS, 20(11), 1503-13, 2006.

Kenealy, SJ, Herrel, LA, Bradford, Y, Schnetz-Boutaud, N, Oksenberg, JR, Hauser, SL, Barcellos, LF, Schmidt, S, Gregory, SG, Pericak-Vance, MA, Haines, JL. Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes Immun, 7(1), 73-6, 2006.

Ma, S, Abou-Khalil, B, Blair, MA, Sutcliffe, JS, Haines, JL, Hedera, P. Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. Neurosci Lett, 394(1), 74-8, 2006.

Ma, S, Davis, TL, Blair, MA, Fang, JY, Bradford, Y, Haines, JL, Hedera, P. Familial essential tremor with apparent autosomal dominant inheritance: should we also consider other inheritance modes. Mov Disord, 21(9), 1368-74, 2006.

McCauley, JL, Hahs, DW, Jiang, L, Scott, WK, Welsh-Bohmer, KA, Jackson, CE, Vance, JM, Pericak-Vance, MA, Haines, JL. Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish. BMC Med Genet, 7, 19, 2006. PMCID:1448207

Motsinger, AA, Brassat, D, Caillier, SJ, Erlich, HA, Walker, K, Steiner, LL, Barcellos, LF, Pericak-Vance, MA, Schmidt, S, Gregory, S, Hauser, SL, Haines, JL, Oksenberg, JR, Ritchie, MD. Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics, , , 2006.

Ritchie, MD, Haas, DW, Motsinger, AA, Donahue, JP, Erdem, H, Raffanti, S, Rebeiro, P, George, AL, Kim, RB, Haines, JL, Sterling, TR. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clin Infect Dis, 43(6), 779-82, 2006.

Thornton-Wells, TA, Moore, JH, Haines, JL. Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data. BMC Bioinformatics, 7, 204, 2006. PMCID:1525209

Canter, Jeffrey A, Eshaghian, Alex, Fessel, Joshua, Summar, Marshall L, Roberts, Jackson L, Morrow, Jason D, Sligh, James E, Haines, Jonathan L. Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation. Free Radic Biol Med, 38(5), 678-83, 2005.

Haines, JL, Hauser, MA, Schmidt, S, Scott, WK, Olson, LM, Gallins, P, Spencer, KL, Kwan, SY, Noureddine, M, Gilbert, JR, Schnetz-Boutaud, N, Agarwal, A, Postel, EA, Pericak-Vance, MA. Complement factor H variant increases the risk of age-related macular degeneration. Science, 308(5720), 419-21, 2005.

Hulgan, T, Haas, DW, Haines, JL, Ritchie, MD, Robbins, GK, Shafer, RW, Clifford, DB, Kallianpur, AR, Summar, M, Canter, JA. Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS, 19(13), 1341-9, 2005.

Kallianpur, AR, Hall, LD, Yadav, M, Byrne, DW, Speroff, T, Dittus, RS, Haines, JL, Christman, BW, Summar, ML. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant, 35(12), 1155-64, 2005.

Liang, X, Schnetz-Boutaud, N, Kenealy, SJ, Jiang, L, Bartlett, J, Lynch, B, Gaskell, PC, Gwirtsman, H, McFarland, L, Bembe, ML, Bronson, P, Gilbert, JR, Martin, ER, Pericak-Vance, MA, Haines, JL. Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus. Mol Psychiatry, , , 2005.

Ma, S, Abou-Khalil, B, Sutcliffe, JS, Haines, JL, Hedera, P. The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. BMC Med Genet, 6, 13, 2005. PMCID:1079842

McCauley, Jacob L, Li, Chun, Jiang, Lan, Olson, Lana M, Crockett, Genea, Gainer, Kimberly, Folstein, Susan E, Haines, Jonathan L, Sutcliffe, James S. Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med Genet, 6(1), 1, 2005. PMCID:546213

Hedera, Peter, Abou-Khalil, Bassel, Crunk, Amy E, Taylor, Kelly A, Haines, Jonathan L, Sutcliffe, James S. Autosomal Dominant Lateral Temporal Epilepsy: Two Families with Novel Mutations in the LGI1 Gene. Epilepsia, 45(3), 218-22, 2004.

Hedera, Peter, Fenichel, Gerald M, Blair, Marcia, Haines, Jonathan L. Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia. Arch Neurol, 61(10), 1600-3, 2004.

Hutcheson, Holli B, Olson, Lana M, Bradford, Yuki, Folstein, Susan E, Santangelo, Susan L, Sutcliffe, James S, Haines, Jonathan L. Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. BMC Med Genet, 5(1), 12, 2004. PMCID:420465

Kallianpur, Asha R, Hall, Lynn D, Yadav, Meeta, Christman, Brian W, Dittus, Robert S, Haines, Jonathan L, Parl, Fritz F, Summar, Marshall L. Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer. Cancer Epidemiol Biomarkers Prev, 13(2), 205-12, 2004.

Kenealy, S J, Babron, M-C, Bradford, Y, Schnetz-Boutaud, N, Haines, J L, Rimmler, J B, Schmidt, S, Pericak-Vance, M A, Barcellos, L F, Lincoln, R R, Oksenberg, J R, Hauser, S L, Clanet, M, Brassat, D, Edan, G, Yaouanq, J, Semana, G, Cournu-Rebeix, I, Lyon-Caen, O, Fontaine, B, , . A second-generation genomic screen for multiple sclerosis. Am J Hum Genet, 75(6), 1070-8, 2004. PMCID:1182142

Kenealy, Shannon J, Schmidt, Silke, Agarwal, Anita, Postel, Eric A, De La Paz, Monica A, Pericak-Vance, Margaret A, Haines, Jonathan L. Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. Mol Vis, 10, 57-61, 2004.

McCauley, J L, Olson, L M, Dowd, M, Amin, T, Steele, A, Blakely, R D, Folstein, S E, Haines, J L, Sutcliffe, J S. Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet B Neuropsychiatr Genet, 127(1), 104-12, 2004.

Thornton-Wells, Tricia A, Moore, Jason H, Haines, Jonathan L. Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet, 20(12), 640-7, 2004.

Williams, Scott M, Haines, Jonathan L, Moore, Jason H. The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings. Bioessays, 26(2), 170-9, 2004.

Dracopoli NC, Haines JL, Korf BR, Norton CC, Seidman CE, Seidman JG, Moir DT, Smith DR, eds. Current Protocols in Human Genetics. New York: John Wiley & Sons, 2003

Hutcheson, Holli B, Bradford, Y, Folstein, S E, Gardiner, M B, Santangelo, S L, Sutcliffe, J S, Haines, J L. Defining the autism minimum candidate gene region on chromosome 7. Am J Med Genet, 117B(1), 90-6, 2003.

Kenealy, Shannon J, Pericak-Vance, Margaret A, Haines, Jonathan L. The genetic epidemiology of multiple sclerosis. J Neuroimmunol, 143(1-2), 7-12, 2003.

Nurmi, E L, Amin, T, Olson, L M, Jacob, M M, McCauley, J L, Lam, A Y, Organ, E L, Folstein, S E, Haines, J L, Sutcliffe, J S. Dense linkage disequilibrium mapping in the 15q11-q13 maternal expression domain yields evidence for association in autism. Mol Psychiatry, 8(6), 570, 2003.

Nurmi, EL, Amin, T, Olson, LM, Jacobs, MM, McCauley, JL, Lam, AY, Organ, EL, Folstein, SE, Haines, JL, Sutcliffe, JS. Dense linkage disequilibrium mapping in the 15q11-q13 maternal expression domain yields evidence for association in autism. Mol Psychiatry, 8(6), 624-34, 570, 2003.

Nurmi, EL, Dowd, M, Tadevosyan-Leyfer, O, Haines, JL, Folstein, SE, Sutcliffe, JS. Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13. J Am Acad Child Adolesc Psychiatry, 42(7), 856-63, 2003.

Oliveira, Sofia A, Scott, William K, Martin, Eden R, Nance, Martha A, Watts, Ray L, Hubble, Jean P, Koller, William C, Pahwa, Rajesh, Stern, Matthew B, Hiner, Bradley C, Ondo, William G, Allen, Fred H, Scott, Burton L, Goetz, Christopher G, Small, Gary W, Mastaglia, Frank, Stajich, Jeffrey M, Zhang, Fengyu, Booze, Michael W, Winn, Michelle P, Middleton, Lefkos T, Haines, Jonathan L, Pericak-Vance, Margaret A, Vance, Jeffery M. Parkin mutations and susceptibility alleles in late-onset Parkinson's disease. Ann Neurol, 53, 624-9, 2003.

Schmidt, Silke, Postel, Eric A, Agarwal, Anita, Allen, I Coy, Walters, Shaune N, De La Paz, Monica A, Scott, William K, Haines, Jonathan L, Pericak-Vance, Margaret A, Gilbert, John R. Detailed Analysis of Allelic Variation in the ABCA4 Gene in Age-Related Maculopathy. Invest Ophthalmol Vis Sci, 44, 2868-75, 2003.

Thornton, Tricia A, Haines, Jonathan L. PowerTrim: An automated decision support algorithm for preprocessing family-based genetic data. Am J Hum Genet, 72(5), 1280-1, 2003. PMCID:1180279

Haines, Jonathan L, Bradford, Yuki, Garcia, Melissa E, Reed, Allison D, Neumeister, Elizabeth, Pericak-Vance, Margaret A, Rimmler, Jacqueline B, Menold, Marissa M, Martin, Eden R, Oksenberg, Jorge R, Barcellos, Lisa F, Lincoln, Robin, Hauser, Stephen L. Multiple susceptibility loci for multiple sclerosis. Hum Mol Genet, 11, 2251-6, 2002.

Li, Yi-Ju, Scott, William K, Hedges, Dale J, Zhang, Fengyu, Gaskell, P Craig, Nance, Martha A, Watts, Ray L, Hubble, Jean P, Koller, William C, Pahwa, Rajesh, Stern, Matthew B, Hiner, Bradley C, Jankovic, Joseph, Allen, Fred A, Goetz, Christopher G, Mastaglia, Frank, Stajich, Jeffrey M, Gibson, Rachel A, Middleton, Lefkos T, Saunders, Ann M, Scott, Burton L, Small, Gary W, Nicodemus, Kristin K, Reed, Allison D, Schmechel, Donald E, Welsh-Bohmer, Kathleen A, Conneally, P Michael, Roses, Allen D, Gilbert, John R, Vance, Jeffery M, Haines, Jonathan L, Pericak-Vance, Margaret A. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet, 70, 985-93, 2002. PMCID:379130

Abou-Khalil, B, Ge, Q, Desai, R, Ryther, R, Bazyk, A, Bailey, R, Haines, J L, Sutcliffe, J S, George, A L. Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation. Neurology, 57, 2265-72, 2001.

Bradford, Y, Haines, J, Hutcheson, H, Gardiner, M, Braun, T, Sheffield, V, Cassavant, T, Huang, W, Wang, K, Vieland, V, Folstein, S, Santangelo, S, Piven, J. Incorporating language phenotypes strengthens evidence of linkage to autism. Am J Med Genet, 105(6), 539-47, 2001.

Haines, JL. Genetic linkage reference maps: access to Internet-based resources. Curr Protoc Hum Genet, Appendix 5, Appendix 5, 2001.

Martin, E R, Scott, W K, Nance, M A, Watts, R L, Hubble, J P, Koller, W C, Lyons, K, Pahwa, R, Stern, M B, Colcher, A, Hiner, B C, Jankovic, J, Ondo, W G, Allen, F H, Goetz, C G, Small, G W, Masterman, D, Mastaglia, F, Laing, N G, Stajich, J M, Ribble, R C, Booze, M W, Rogala, A, Hauser, M A, Zhang, F, Gibson, R A, Middleton, L T, Roses, A D, Haines, J L, Scott, B L, Pericak-Vance, M A, Vance, J M. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. JAMA, 286, 2245-50, 2001.

Nurmi, EL, Bradford, Y, Chen, Y, Hall, J, Arnone, B, Gardiner, MB, Hutcheson, HB, Gilbert, JR, Pericak-Vance, MA, Copeland-Yates, SA, Michaelis, RC, Wassink, TH, Santangelo, SL, Sheffield, VC, Piven, J, Folstein, SE, Haines, JL, Sutcliffe, JS. Linkage disequilibrium at the Angelman syndrome gene UBE3A in autism families. Genomics, 77(1-2), 105-13, 2001.

Pearson, D L, Dawling, S, Walsh, W F, Haines, J L, Christman, B W, Bazyk, A, Scott, N, Summar, M L. Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. N Engl J Med, 344(24), 1832-8, 2001.

Tiller, GE, Hannig, VL, Dozier, D, Carrel, L, Trevarthen, KC, Wilcox, WR, Mundlos, S, Haines, JL, Gedeon, AK, Gecz, J. A recurrent RNA-splicing mutation in the SEDL gene causes X-linked spondyloepiphyseal dysplasia tarda. Am J Hum Genet, 68(6), 1398-407, 2001. PMCID:1226126

Scott WK, Grubber JM, Conneally PM, Small GW, Hulette CM, Rosenberg CK, Saunders AM, Roses AD, Haines JL and Pericak-Vance MA. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. Am J Hum Genet, 66(3), 922-932, 2000.

Xie, HG, Stein, CM, Kim, RB, Gainer, JV, Sofowora, G, Dishy, V, Brown, NJ, Goree, RE, Haines, JL, Wood, AJ. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin Pharmacol Ther, 67(6), 670-5, 2000.

Collaborative Linkage Study of Autism: Barrett S, Beck JC, Bernier R, Bisson E, Braun TA, Casavant TL, Childress D, Folstein SE, Garia M, Gardiner MB, Gilman S, Haines JL, Hopkins K, Landa R, Meyer NH, Mullane JA, Nishimura DY, Palmer P, Piven J, Purdy J, Santangelo SL, Searby C, Sheffield V, Singleton J, Slager S, Struchen T, Svenson S, Vieland V, Wang K, Winklosky B. An autosomal genomic screen for Autism. Neuropsychiatric Genetics, 609-615, 88, 1999.

Garcia, M E, Haines, J L. Hunting genetic diseases: exploring a multistage approach to identifying disease loci. Genet Epidemiol, 17 Suppl 1, S557-62, 1999.

Haines JL, Pericak-Vance MA. The Genetics of Multiple Sclerosis. Theofilopoulos AN, ed. Current Direction in Autoimmunity: Genes and Genetics of Autoimmunity, Basel: S. Karger, Inc, 1, 273-288, 1999.

Haines, J L, Pericak-Vance, M A. Genetics of multiple sclerosis. Curr Dir Autoimmun, 1, 273-88, 1999.

Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott W, Kawarai T, Song Y, Hill D, Abou-donia S, Martin E, Vance JJ, Yu G, Orlacchio A, Pei Y, Nishimura M, Supala A, Roberge B, Sanders A, Roses AD, Schmechel D, Crane A, Sorbi S, Bruni A, Small G, Conneally PM, Haines Jl, Van Leuven F, St George-Hyslop PH, Farrer LA, Pericak-Vance MA. A comprehensive examination of an alpha-2-macroglobullin insertin-deletion polymorphism in Alzheimer disease. Nature Genetics, 22, 19-20, 1999.

Scott WK, Grubber JM, Abou-Donia SM, Church TD, Saunders AM, Roses AD, Pericak-Vance MA, Conneally PM, Small GW, Haines JL. Further evidence linking late-onset Alzheimer disease with chromosome 12. JAMA, 281, 513-514, 1999.

Scott WK, Yamaoka LH, Bass ML, Gaskell PC, Conneally PM, Small GW, Farrer LA, Auerbach SA, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. Neurogenet, 1, 179-183, 1999.

The Mutiple Sclerosis Genetics Group: Seboun E, Oksenberg JR, Rombos A, Usuku K, Goodkin DE, Lincoln RR, Wong M, Pham-Dinh D, Boesplug-Tanguy O, Carsique R, Fitoussi R, Gartioux C, Ryese C, Ribierre F, Faure S, Fizames C, Gyapay G, Weissenbach J, Dautigny A, Rimmler JB, Garica ME, Pericak-Vance MA, Haines JL, Hauser SL. Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics, 2, 155-162, 1999.

Xie, HG, Stein, CM, Kim, RB, Xiao, ZS, He, N, Zhou, HH, Gainer, JV, Brown, NJ, Haines, JL, Wood, AJ. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics, 9(4), 511-6, 1999.

Farrer LA, Cupples LA, Myers RH, van Duijn CM, Mayeux R, Haines JL, Kukull WA, Hyman B, Pericak-Vance MA, Risch N. Effects of Age and Ethnicity on the Link between APOE e4 and Alzheimer Disease. JAMA, 279, 580-582, 1998.

Haines JL, Boustany RMN, Alroy J, Auger KJ, Shook KS, Terwedow H, Lerner TJ. Chromosomal localization of two genes underlying late-infantile neuronal ceroid lipofuscinosis. Neurogenetics, 1, 217-222, 1998.

Haines, J L, Terwedow, H A, Burgess, K, Pericak-Vance, M A, Rimmler, J B, Martin, E R, Oksenberg, J R, Lincoln, R, Zhang, D Y, Banatao, D R, Gatto, N, Goodkin, D E, Hauser, S L. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum Mol Genet, 7(8), 1229-34, 1998.

Kwiatkowska J, Jozwiak S, Hall F, Henske EP, Haines JL, McNamara P, Braiser J, Wigowska-Sowinska J, Kasprzyk-Obara J, Short MP, Kwiatkowski DJ. Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet , 62, 277-285, 1998.

The Multiple Sclerosis Genetics Group: Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, Oksenberg JR, Lincoln R, Zhang DY, Banatao DR, Gatto N, Goodkin DE, Hauser SL. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum Mol Genet, 7(8), 1229-1234, 1998.

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Pericak-Vance MA, Risch N, van Dujn CM. Effects of age, sex, and ethnicity on the associations between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA , 278, 1349-1356, 1997.

Pericak-Vance MA, Bass MP, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA, Menold MM, Conneally PM, Small GW, Vance JM, Saunders AM, Roses AD, Haines JL. Complete genomic screen in late-onset familial Alzheimer disease: Evidence for a new locus on Chromosome 12. JAMA, 278, 1237-1241, 1997.

Scott WK, Saunders AM, Gaskell PC, Locke PA, Growdon JH, Farrer LA, Auerbach SA, Roses AD, Haines JL, Pericak-Vance MA. Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. Ann Neurol, 42, 376-378, 1997.

Postdoctoral Position Available

Postdoctoral Position Details
Postdoctoral position available to work on the genetic epidemiology of dementia, multiple sclerosis, or age-related macular degeneration.

Updated Date

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