Vanderbilt University School of Medicine

Magnuson, Mark A. , M.D.
Professor of Molecular Physiology and Biophysics
Louise B. McGavock Chair
Professor of Medicine
Professor of Cell and Developmental Biology

Lab Url: http://labnodes.vanderbilt.edu/community/profile/id/5

Phone Number: (615) 322-7006

Email Address:mark.magnuson@vanderbilt.edu

Magnuson, Mark's picture

Office Address   Mailing Address

9475 MRB IV

Center for Stem Cell Biology 9465 MRB IV 37232-0494


Research Keywords
Pancreatic cellular plasticity and reprogramming, Mechanisms of beta cell dedifferentiation, Stem and progenitor cell biology, Bio/informatics, Mouse models, Diabetes

Research Description
We are interested in developing new types of therapies for the treatment of diabetes. This requires a deep understanding of pancreatic beta cell function and development. My laboratory has a long history of developing novel and mouse models using gene targeting and recombinase-mediated cassette exchange (RMCE) strategies, and using these mice to gain important new insights and understanding of the molecular physiology of diabetes. However, better models that more closely mimic the physiology and pathophysiology of human diseases, including type 1 and type 2 diabetes, are needed. Towards this end, we have been developing several novel strategies and methods that will enable us to generate better animal models that more closely model the human.

Publications
Magnuson, MA, Osipovich, AB. Pancreas-specific cre driver lines and considerations for their prudent use. Cell Metab, 18(1), 9-20, 2013.

Pan, FC, Bankaitis, ED, Boyer, D, Xu, X, Van de Casteele, M, Magnuson, MA, Heimberg, H, Wright, CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development, 140(4), 751-64, 2013.

Choi, E, Kraus, MR, Lemaire, LA, Yoshimoto, M, Vemula, S, Potter, LA, Manduchi, E, Stoeckert, CJ, Grapin-Botton, A, Magnuson, MA. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells, 30(10), 2297-308, 2012.

Kopinke, D, Brailsford, M, Pan, FC, Magnuson, MA, Wright, CV, Murtaugh, LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol, 362(1), 57-64, 2012. PMCID:3254730

McKenna, NJ, Howard, CL, Aufiero, M, Easton-Marks, J, Steffen, DL, Becnel, LB, Magnuson, MA, McIndoe, RA, Cartailler, JP. Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia. Mol Endocrinol, 26(10), 1675-81, 2012.

Chen, SX, Osipovich, AB, Ustione, A, Potter, LA, Hipkens, S, Gangula, R, Yuan, W, Piston, DW, Magnuson, MA. Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech, 4(4), 537-47, 2011. PMCID:3124063

Gu, Y, Lindner, J, Kumar, A, Yuan, W, Magnuson, MA. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes, 60(3), 827-37, 2011. PMCID:3124063

Papizan, JB, Singer, RA, Tschen, SI, Dhawan, S, Friel, JM, Hipkens, SB, Magnuson, MA, Bhushan, A, Sussel, L. Nkx2.2 repressor complex regulates islet I?-cell specification and prevents I?-to-I?-cell reprogramming. Genes Dev, 25(21), 2291-305, 2011. PMCID:3219233

Petersen, DR, Gustavsen, C, Lindskog, SR, Magnuson, MA, Zaret, KS, Serup, P. Engineering Artificial Signaling Centers to Polarize Embryoid Body Differentiation. Stem Cells Dev, , , 2011. PMCID:3219233

Plank, JL, Frist, AY, Legrone, AW, Magnuson, MA, Labosky, PA. Loss of Foxd3 Results in Decreased I?-Cell Proliferation and Glucose Intolerance During Pregnancy. Endocrinology, 152(12), 4589-600, 2011.

Porat, S, Weinberg-Corem, N, Tornovsky-Babaey, S, Schyr-Ben-Haroush, R, Hija, A, Stolovich-Rain, M, Dadon, D, Granot, Z, Ben-Hur, V, White, P, Girard, CA, Karni, R, Kaestner, KH, Ashcroft, FM, Magnuson, MA, Saada, A, Grimsby, J, Glaser, B, Dor, Y. Control of pancreatic I? cell regeneration by glucose metabolism. Cell Metab, 13(4), 440-9, 2011. PMCID:3115606

Potter, LA, Choi, E, Hipkens, SB, Wright, CV, Magnuson, MA. An RMCE-derived cyan fluorescent protein reporter allele for Pdx1. Genesis, , , 2011.

Salpeter, SJ, Klochendler, A, Weinberg-Corem, N, Porat, S, Granot, Z, Shapiro, AM, Magnuson, MA, Eden, A, Grimsby, J, Glaser, B, Dor, Y. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic I?-cells through glycolysis and calcium channels. Endocrinology, 152(7), 2589-98, 2011. PMCID:3115606

Watanabe, H, Yang, T, Stroud, DM, Lowe, JS, Harris, L, Atack, TC, Wang, DW, Hipkens, SB, Leake, B, Hall, L, Kupershmidt, S, Chopra, N, Magnuson, MA, Tanabe, N, Knollmann, BC, George, AL, Roden, DM. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation, 124(9), 1001-11, 2011.

Artner, I, Hang, Y, Mazur, M, Yamamoto, T, Guo, M, Lindner, J, Magnuson, MA, Stein, R. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes, 59(10), 2530-9, 2010. PMCID:3124063

Boulbes, D, Chen, CH, Shaikenov, T, Agarwal, NK, Peterson, TR, Addona, TA, Keshishian, H, Carr, SA, Magnuson, MA, Sabatini, DM, Sarbassov, dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res, 8(6), 896-906, 2010. PMCID:2896829

Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010. PMCID:2882427

Kumar, A, Lawrence, JC, Jung, DY, Ko, HJ, Keller, SR, Kim, JK, Magnuson, MA, Harris, TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes, 59(6), 1397-406, 2010. PMCID:2874700

Lee, K, Gudapati, P, Dragovic, S, Spencer, C, Joyce, S, Killeen, N, Magnuson, MA, Boothby, M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity, 32(6), 743-53, 2010.

Masui, T, Swift, GH, Deering, T, Shen, C, Coats, WS, Long, Q, Els??sser, HP, Magnuson, MA, MacDonald, RJ. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology, 139(1), 270-80, 2010. PMCID:2902682

Siuta, MA, Robertson, SD, Kocalis, H, Saunders, C, Gresch, PJ, Khatri, V, Shiota, C, Kennedy, JP, Lindsley, CW, Daws, LC, Polley, DB, Veenstra-Vanderweele, J, Stanwood, GD, Magnuson, MA, Niswender, KD, Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol, 8(6), e1000393, 2010. PMCID:2882427

Treins, C, Warne, PH, Magnuson, MA, Pende, M, Downward, J. Rictor is a novel target of p70 S6 kinase-1. Oncogene, 29(7), 1003-16, 2010. PMCID:2874700

Berglund, ED, Lee-Young, RS, Lustig, DG, Lynes, SE, Donahue, EP, Camacho, RC, Meredith, ME, Magnuson, MA, Charron, MJ, Wasserman, DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest, 119(8), 2412-22, 2009. PMCID:2719934

Huppert, SS, Magnuson, MA. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Sci Signal, 2(83), pe50, 2009. PMCID:2882427

Wang, S, Jensen, JN, Seymour, PA, Hsu, W, Dor, Y, Sander, M, Magnuson, MA, Serup, P, Gu, G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A, 106(24), 9715-20, 2009. PMCID:2701002

Zhang, H, Ables, ET, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev, 126(11-12), 958-73, 2009. PMCID:2882427

Burlison, JS, Long, Q, Fujitani, Y, Wright, CV, Magnuson, MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol, 316(1), 74-86, 2008. PMCID:2425677

Elrod, JW, Harrell, M, Flagg, TP, Gundewar, S, Magnuson, MA, Nichols, CG, Coetzee, WA, Lefer, DJ. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Circulation, 117(11), 1405-13, 2008.

Gannon, M, Ables, ET, Crawford, L, Lowe, D, Offield, MF, Magnuson, MA, Wright, CV. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314(2), 406-17, 2008. PMCID:2269701

Hagan, GN, Lin, Y, Magnuson, MA, Avruch, J, Czech, MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol, 28(13), 4215-26, 2008. PMCID:2447144

Hori, K, Cholewa-Waclaw, J, Nakada, Y, Glasgow, SM, Masui, T, Henke, RM, Wildner, H, Martarelli, B, Beres, TM, Epstein, JA, Magnuson, MA, Macdonald, RJ, Birchmeier, C, Johnson, JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev, 22(2), 166-78, 2008. PMCID:2192752

Kumar, A, Harris, TE, Keller, SR, Choi, KM, Magnuson, MA, Lawrence, JC. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol, 28(1), 61-70, 2008. PMCID:2223287

Shiota, M, Magnuson, MA. Hepatic glucose sensing: does flux matter. J Clin Invest, 118(3), 841-4, 2008. PMCID:2248806

Zelent, B, Odili, S, Buettger, C, Shiota, C, Grimsby, J, Taub, R, Magnuson, MA, Vanderkooi, JM, Matschinsky, FM. Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. Biochem J, 413(2), 269-80, 2008.

Burgess, SC, He, T, Yan, Z, Lindner, J, Sherry, AD, Malloy, CR, Browning, JD, Magnuson, MA. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab, 5(4), 313-20, 2007. PMCID:2680089

Magnuson, MA, Burlison, JS. Caveats and considerations for performing pancreas-specific gene manipulations in the mouse. Diabetes Obes Metab, 9 Suppl 2, 5-13, 2007.

Masui, T, Long, Q, Beres, TM, Magnuson, MA, MacDonald, RJ. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev, 21(20), 2629-43, 2007. PMCID:2000326

Niswender, KD, Magnuson, MA. Obesity and the beta cell: lessons from leptin. J Clin Invest, 117(10), 2753-6, 2007. PMCID:1994637

Pearce, LR, Huang, X, Boudeau, J, Paw??owski, R, Wullschleger, S, Deak, M, Ibrahim, AF, Gourlay, R, Magnuson, MA, Alessi, DR. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J, 405(3), 513-22, 2007. PMCID:2267312

Pino, MF, Kim, KA, Shelton, KD, Lindner, J, Odili, S, Li, C, Collins, HW, Shiota, M, Matschinsky, FM, Magnuson, MA. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations. J Biol Chem, , , 2007.

Wang, S, Zhang, J, Zhao, A, Hipkens, S, Magnuson, MA, Gu, G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev, 124(11-12), 898-910, 2007. PMCID:2141686

Yoshida, K, Murao, K, Imachi, H, Cao, WM, Yu, X, Li, J, Ahmed, RA, Kitanaka, N, Wong, NC, Unterman, TG, Magnuson, MA, Ishida, T. Pancreatic Glucokinase is Activated by Insulin-like Growth Factor-I. Endocrinology, , , 2007.

Doliba, NM, Qin, W, Vatamaniuk, MZ, Buettger, CW, Collins, HW, Magnuson, MA, Kaestner, KH, Wilson, DF, Carr, RD, Matschinsky, FM. Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. Am J Physiol Endocrinol Metab, 291(3), E525-35, 2006.

Fujitani, Y, Fujitani, S, Boyer, DF, Gannon, M, Kawaguchi, Y, Ray, M, Shiota, M, Stein, RW, Magnuson, MA, Wright, CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev, 20(2), 253-66, 2006. PMCID:1356115

Fujitani, Y, Fujitani, S, Luo, H, Qiu, F, Burlison, J, Long, Q, Kawaguchi, Y, Edlund, H, MacDonald, RJ, Furukawa, T, Fujikado, T, Magnuson, MA, Xiang, M, Wright, CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development, 133(22), 4439-50, 2006.

Liu, K, Hipkens, S, Yang, T, Abraham, R, Zhang, W, Chopra, N, Knollmann, B, Magnuson, MA, Roden, DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis, 44(11), 556-64, 2006.

Matschinsky, FM, Magnuson, MA, Zelent, D, Jetton, TL, Doliba, N, Han, Y, Taub, R, Grimsby, J. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes, 55(1), 1-12, 2006.

Shiota, C, Woo, JT, Lindner, J, Shelton, KD, Magnuson, MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell, 11(4), 583-9, 2006.

Stiles, BL, Kuralwalla-Martinez, C, Guo, W, Gregorian, C, Wang, Y, Tian, J, Magnuson, MA, Wu, H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol, 26(7), 2772-81, 2006. PMCID:1430339

Babaev, Vladimir R, Yancey, Patricia G, Ryzhov, Sergey V, Kon, Valentina, Breyer, Matthew D, Magnuson, Mark A, Fazio, Sergio, Linton, Macrae F. Conditional Knockout of Macrophage PPAR{gamma} Increases Atherosclerosis in C57BL/6 and Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol, , , 2005.

Gloyn, AL, Odili, S, Zelent, D, Buettger, C, Castleden, HA, Steele, AM, Stride, A, Shiota, C, Magnuson, MA, Lorini, R, d''Annunzio, G, Stanley, CA, Kwagh, J, van Schaftingen, E, Veiga-da-Cunha, M, Barbetti, F, Dunten, P, Han, Y, Grimsby, J, Taub, R, Ellard, S, Hattersley, AT, Matschinsky, FM. Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. J Biol Chem, 280(14), 14105-13, 2005.

Guan, Youfei, Hao, Chuanming, Cha, Dae Ryong, Rao, Reena, Lu, Wendell, Kohan, Donald E, Magnuson, Mark A, Redha, Reyadh, Zhang, Yahua, Breyer, Matthew D. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med, , , 2005.

Gunawardana, Subhadra C, Hara, Manami, Bell, Graeme I, Head, W Steven, Magnuson, Mark A, Piston, David W. Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells. In Vitro Cell Dev Biol Anim, 41(1-2), 7-11, 2005.

Jones, JR, Shelton, KD, Magnuson, MA. Strategies for the use of site-specific recombinases in genome engineering. Methods Mol Med, 103, 245-57, 2005.

Jones, Julie R, Barrick, Cordelia, Kim, Kyoung-Ah, Lindner, Jill, Blondeau, Bertrand, Fujimoto, Yuka, Shiota, Masakazu, Kesterson, Robert A, Kahn, Barbara B, Magnuson, Mark A. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A, 102(17), 6207-12, 2005. PMCID:556131

Lee, JY, Ristow, M, Lin, X, White, MF, Magnuson, MA, Hennighausen, L. RIP-Cre revisited: Evidence for impairments of pancreatic beta-cell function. J Biol Chem, , , 2005.

Miura, A, Yamagata, K, Kakei, M, Hatakeyama, H, Takahashi, N, Fukui, K, Nammo, T, Yoneda, K, Inoue, Y, Sladek, FM, Magnuson, MA, Kasai, H, Miyagawa, J, Gonzalez, FJ, Shimomura, I. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem, , , 2005.

Park, SY, Wang, X, Chen, Z, Powers, AC, Magnuson, MA, Head, WS, Piston, DW, Bell, GI. Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis, 43(2), 80-6, 2005.

Roccisana, J, Reddy, V, Vasavada, RC, Gonzalez-Pertusa, JA, Magnuson, MA, Garcia-Oca??a, A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes, 54(7), 2090-102, 2005.

Romero-Gallo, J, Sozmen, EG, Chytil, A, Russell, WE, Whitehead, R, Parks, WT, Holdren, MS, Her, MF, Gautam, S, Magnuson, M, Moses, HL, Grady, WM. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene, 24(18), 3028-41, 2005.

Schonhoff, S, Baggio, L, Ratineau, C, Ray, SK, Lindner, J, Magnuson, MA, Drucker, DJ, Leiter, AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol, 25(10), 4189-99, 2005. PMCID:1087718

Shiota, C, Rocheleau, JV, Shiota, M, Piston, DW, Magnuson, MA. Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Am J Physiol Endocrinol Metab, 289(4), E570-7, 2005.

Thierbach, R, Schulz, TJ, Isken, F, Voigt, A, Mietzner, B, Drewes, G, von Kleist-Retzow, JC, Wiesner, RJ, Magnuson, MA, Puccio, H, Pfeiffer, AF, Steinberg, P, Ristow, M. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet, 14(24), 3857-64, 2005.

Wang, CZ, Wang, Y, Di, A, Magnuson, MA, Ye, H, Roe, MW, Nelson, DJ, Bell, GI, Philipson, LH. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem Biophys Res Commun, 330(4), 1073-9, 2005.

Biondi, Christine A, Gartside, Michael G, Waring, Paul, Loffler, Kelly A, Stark, Mitchell S, Magnuson, Mark A, Kay, Graham F, Hayward, Nicholas K. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol, 24(8), 3125-31, 2004. PMCID:381682

Burgess, SC, Hausler, N, Merritt, M, Jeffrey, FM, Storey, C, Milde, A, Koshy, S, Lindner, J, Magnuson, MA, Malloy, CR, Sherry, AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem, 279(47), 48941-9, 2004.

Chu, Chang An, Fujimoto, Yuka, Igawa, Kayano, Grimsby, Joseph, Grippo, Joseph F, Magnuson, Mark A, Cherrington, Alan D, Shiota, Masakazu. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am J Physiol Gastrointest Liver Physiol, 286(4), G627-34, 2004.

Dentin, R, P??gorier, JP, Benhamed, F, Foufelle, F, Ferr??, P, Fauveau, V, Magnuson, MA, Girard, J, Postic, C. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem, 279(19), 20314-26, 2004.

Doliba, NM, Qin, W, Vatamaniuk, MZ, Li, C, Zelent, D, Najafi, H, Buettger, CW, Collins, HW, Carr, RD, Magnuson, MA, Matschinsky, FM. Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine. Am J Physiol Endocrinol Metab, 286(5), E834-43, 2004.

Gorogawa, S, Fujitani, Y, Kaneto, H, Hazama, Y, Watada, H, Miyamoto, Y, Takeda, K, Akira, S, Magnuson, MA, Yamasaki, Y, Kajimoto, Y, Hori, M. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun, 319(4), 1159-70, 2004.

Long, Q, Shelton, KD, Lindner, J, Jones, JR, Magnuson, MA. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Genesis, 39(4), 256-62, 2004.

Moates, JM, Magnuson, MA. The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised. Diabetologia, 47(9), 1632-40, 2004.

Schneider, A, Guan, Y, Zhang, Y, Magnuson, MA, Pettepher, C, Loftin, CD, Langenbach, R, Breyer, RM, Breyer, MD. Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis, 40(1), 7-14, 2004.

Stiles, B, Wang, Y, Stahl, A, Bassilian, S, Lee, WP, Kim, YJ, Sherwin, R, Devaskar, S, Lesche, R, Magnuson, MA, Wu, H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A, 101(7), 2082-7, 2004. PMCID:357055

Crabtree, JS, Scacheri, PC, Ward, JM, McNally, SR, Swain, GP, Montagna, C, Hager, JH, Hanahan, D, Edlund, H, Magnuson, MA, Garrett-Beal, L, Burns, AL, Ried, T, Chandrasekharappa, SC, Marx, SJ, Spiegel, AM, Collins, FS. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol, 23(17), 6075-85, 2003. PMCID:180910

Gloyn, AL, Noordam, K, Willemsen, MA, Ellard, S, Lam, WW, Campbell, IW, Midgley, P, Shiota, C, Buettger, C, Magnuson, MA, Matschinsky, FM, Hattersley, AT. Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes, 52(9), 2433-40, 2003.

Grimsby, J, Sarabu, R, Corbett, WL, Haynes, NE, Bizzarro, FT, Coffey, JW, Guertin, KR, Hilliard, DW, Kester, RF, Mahaney, PE, Marcus, L, Qi, L, Spence, CL, Tengi, J, Magnuson, MA, Chu, CA, Dvorozniak, MT, Matschinsky, FM, Grippo, JF. Allosteric activators of glucokinase: potential role in diabetes therapy. Science, 301(5631), 370-3, 2003.

Hara, M, Wang, X, Kawamura, T, Bindokas, VP, Dizon, RF, Alcoser, SY, Magnuson, MA, Bell, GI. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab, 284(1), E177-83, 2003.

Henderson, CJ, Otto, DM, Carrie, D, Magnuson, MA, McLaren, AW, Rosewell, I, Wolf, CR. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem, 278(15), 13480-6, 2003.

Lee, YH, Magnuson, MA, Muppala, V, Chen, SS. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol, 23(3), 923-32, 2003. PMCID:140695

Magnuson, MA, She, P, Shiota, M. Gene-altered mice and metabolic flux control. J Biol Chem, 278(35), 32485-8, 2003.

Mart?-n, J, Hunt, SL, Dubus, P, Sotillo, R, N??hm??-P??lluard, F, Magnuson, MA, Parlow, AF, Malumbres, M, Ortega, S, Barbacid, M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene, 22(34), 5261-9, 2003.

Miyatsuka, T, Kaneto, H, Kajimoto, Y, Hirota, S, Arakawa, Y, Fujitani, Y, Umayahara, Y, Watada, H, Yamasaki, Y, Magnuson, MA, Miyazaki, J, Hori, M. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun, 310(3), 1017-25, 2003.

Ristow, M, Mulder, H, Pomplun, D, Schulz, TJ, M??ller-Schmehl, K, Krause, A, Fex, M, Puccio, H, M??ller, J, Isken, F, Spranger, J, M??ller-Wieland, D, Magnuson, MA, M??hlig, M, Koenig, M, Pfeiffer, AF. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest, 112(4), 527-34, 2003. PMCID:171391

Rosen, ED, Kulkarni, RN, Sarraf, P, Ozcan, U, Okada, T, Hsu, CH, Eisenman, D, Magnuson, MA, Gonzalez, FJ, Kahn, CR, Spiegelman, BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol, 23(20), 7222-9, 2003. PMCID:230305

Schulla, V, Renstr??m, E, Feil, R, Feil, S, Franklin, I, Gjinovci, A, Jing, XJ, Laux, D, Lundquist, I, Magnuson, MA, Oberm??ller, S, Olofsson, CS, Salehi, A, Wendt, A, Klugbauer, N, Wollheim, CB, Rorsman, P, Hofmann, F. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J, 22(15), 3844-54, 2003. PMCID:169062

She, P, Burgess, SC, Shiota, M, Flakoll, P, Donahue, EP, Malloy, CR, Sherry, AD, Magnuson, MA. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes, 52(7), 1649-54, 2003.

Christesen, HB, Jacobsen, BB, Odili, S, Buettger, C, Cuesta-Munoz, A, Hansen, T, Brusgaard, K, Massa, O, Magnuson, MA, Shiota, C, Matschinsky, FM, Barbetti, F. The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Diabetes, 51(4), 1240-6, 2002.

Chytil, A, Magnuson, MA, Wright, CV, Moses, HL. Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis, 32(2), 73-5, 2002.

Jones, JR, Shelton, KD, Guan, Y, Breyer, MD, Magnuson, MA. Generation and functional confirmation of a conditional null PPARgamma allele in mice. Genesis, 32(2), 134-7, 2002.

Kulkarni, RN, Holzenberger, M, Shih, DQ, Ozcan, U, Stoffel, M, Magnuson, MA, Kahn, CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet, 31(1), 111-5, 2002.

Rizzo, MA, Magnuson, MA, Drain, PF, Piston, DW. A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin. J Biol Chem, 277(37), 34168-75, 2002.

Shiota, C, Larsson, O, Shelton, KD, Shiota, M, Efanov, AM, Hoy, M, Lindner, J, Kooptiwut, S, Juntti-Berggren, L, Gromada, J, Berggren, PO, Magnuson, MA. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem, 277(40), 37176-83, 2002.

Xin, HB, Senbonmatsu, T, Cheng, DS, Wang, YX, Copello, JA, Ji, GJ, Collier, ML, Deng, KY, Jeyakumar, LH, Magnuson, MA, Inagami, T, Kotlikoff, MI, Fleischer, S. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416(6878), 334-8, 2002.

Efanov, AM, H??y, M, Br??nstr??m, R, Zaitsev, SV, Magnuson, MA, Efendic, S, Gromada, J, Berggren, PO. The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochem Biophys Res Commun, 284(4), 918-22, 2001.

Holla, VR, Adas, F, Imig, JD, Zhao, X, Price, E, Olsen, N, Kovacs, WJ, Magnuson, MA, Keeney, DS, Breyer, MD, Falck, JR, Waterman, MR, Capdevila, JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A, 98(9), 5211-6, 2001. PMCID:33189

Jetton, TL, Shiota, M, Knobel, SM, Piston, DW, Cherrington, AD, Magnuson, MA. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int J Exp Diabetes Res, 2(3), 173-86, 2001. PMCID:2478546

Nj??lstad, PR, S??vik, O, Cuesta-Mu??oz, A, Bj??rkhaug, L, Massa, O, Barbetti, F, Undlien, DE, Shiota, C, Magnuson, MA, Molven, A, Matschinsky, FM, Bell, GI. Neonatal diabetes mellitus due to complete glucokinase deficiency. N Engl J Med, 344(21), 1588-92, 2001.

Postic, C, Shiota, M, Magnuson, MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res, 56, 195-217, 2001.

Sakai, T, Johnson, KJ, Murozono, M, Sakai, K, Magnuson, MA, Wieloch, T, Cronberg, T, Isshiki, A, Erickson, HP, F??ssler, R. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med, 7(3), 324-30, 2001.

Shiota, M, Postic, C, Fujimoto, Y, Jetton, TL, Dixon, K, Pan, D, Grimsby, J, Grippo, JF, Magnuson, MA, Cherrington, AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes, 50(3), 622-9, 2001.

Sund, NJ, Vatamaniuk, MZ, Casey, M, Ang, SL, Magnuson, MA, Stoffers, DA, Matschinsky, FM, Kaestner, KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev, 15(13), 1706-15, 2001. PMCID:312732

Gannon, M, Shiota, C, Postic, C, Wright, CV, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000.

Grimsby, J, Coffey, JW, Dvorozniak, MT, Magram, J, Li, G, Matschinsky, FM, Shiota, C, Kaur, S, Magnuson, MA, Grippo, JF. Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem, 275(11), 7826-31, 2000.

Michael, MD, Kulkarni, RN, Postic, C, Previs, SF, Shulman, GI, Magnuson, MA, Kahn, CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell, 6(1), 87-97, 2000.

Postic, C, Magnuson, MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis, 26(2), 149-50, 2000.

She, P, Shiota, M, Shelton, KD, Chalkley, R, Postic, C, Magnuson, MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol, 20(17), 6508-17, 2000. PMCID:86125

Silva, JP, K??hler, M, Graff, C, Oldfors, A, Magnuson, MA, Berggren, PO, Larsson, NG. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet, 26(3), 336-40, 2000.

Sund, NJ, Ang, SL, Sackett, SD, Shen, W, Daigle, N, Magnuson, MA, Kaestner, KH. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol, 20(14), 5175-83, 2000. PMCID:85966

Wan, YJ, An, D, Cai, Y, Repa, JJ, Hung-Po Chen, T, Flores, M, Postic, C, Magnuson, MA, Chen, J, Chien, KR, French, S, Mangelsdorf, DJ, Sucov, HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol, 20(12), 4436-44, 2000. PMCID:85811

Davis, EA, Cuesta-Mu??oz, A, Raoul, M, Buettger, C, Sweet, I, Moates, M, Magnuson, MA, Matschinsky, FM. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia, 42(10), 1175-86, 1999.

Kennedy, CR, Zhang, Y, Brandon, S, Guan, Y, Coffee, K, Funk, CD, Magnuson, MA, Oates, JA, Breyer, MD, Breyer, RM. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med, 5(2), 217-20, 1999.

Kulkarni, RN, Br??ning, JC, Winnay, JN, Postic, C, Magnuson, MA, Kahn, CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell, 96(3), 329-39, 1999.

Kupershmidt, S, Yang, T, Anderson, ME, Wessels, A, Niswender, KD, Magnuson, MA, Roden, DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res, 84(2), 146-52, 1999.

Lu, JT, Son, YJ, Lee, J, Jetton, TL, Shiota, M, Moscoso, L, Niswender, KD, Loewy, AD, Magnuson, MA, Sanes, JR, Emeson, RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci, 14(2), 99-120, 1999.

Piston, DW, Knobel, SM, Postic, C, Shelton, KD, Magnuson, MA. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J Biol Chem, 274(2), 1000-4, 1999.

Postic, C, Magnuson, MA. [Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique. Journ Annu Diabetol Hotel Dieu, , 115-24, 1999.

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999.

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J Biol Chem, 274(52), 37125-30, 1999.

Williams, CP, Postic, C, Robin, D, Robin, P, Parrinello, J, Shelton, K, Printz, RL, Magnuson, MA, Granner, DK, Forest, C, Chalkley, R. Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Mol Cell Endocrinol, 148(1-2), 67-77, 1999.

Castillo, SO, Baffi, JS, Palkovits, M, Goldstein, DS, Kopin, IJ, Witta, J, Magnuson, MA, Nikodem, VM. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol Cell Neurosci, 11(1-2), 36-46, 1998.

Jetton, TL, Moates, JM, Lindner, J, Wright, CV, Magnuson, MA. Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proc Natl Acad Sci U S A, 95(15), 8654-9, 1998. PMCID:21131

Matschinsky, FM, Glaser, B, Magnuson, MA. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes, 47(3), 307-15, 1998.

Weaver, CD, Partridge, JG, Yao, TL, Moates, JM, Magnuson, MA, Verdoorn, TA. Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas. Mol Pharmacol, 54(4), 639-46, 1998.

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997. PMCID:20311

Kesavan, P, Wang, L, Davis, E, Cuesta, A, Sweet, I, Niswender, K, Magnuson, MA, Matschinsky, FM. Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). Biochem J, 322 ( Pt 1), 57-63, 1997. PMCID:1218158

Moates, JM, Postic, C, Decaux, JF, Girard, J, Magnuson, MA. Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene. Genomics, 45(1), 185-93, 1997.

Niswender, KD, Postic, C, Jetton, TL, Bennett, BD, Piston, DW, Efrat, S, Magnuson, MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem, 272(36), 22564-9, 1997.

Niswender, KD, Postic, C, Shiota, M, Jetton, TL, Magnuson, MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem Soc Trans, 25(1), 113-7, 1997.

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997.

Qu, S, Niswender, KD, Ji, Q, van der Meer, R, Keeney, D, Magnuson, MA, Wisdom, R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development, 124(20), 3999-4008, 1997.

Bennett, BD, Jetton, TL, Ying, G, Magnuson, MA, Piston, DW. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J Biol Chem, 271(7), 3647-51, 1996.

Moates, JM, Shelton, KD, Magnuson, MA. Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Mol Endocrinol, 10(6), 723-31, 1996.

Offield, MF, Jetton, TL, Labosky, PA, Ray, M, Stein, RW, Magnuson, MA, Hogan, BL, Wright, CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development, 122(3), 983-95, 1996.

Parsa, R, Decaux, JF, Bossard, P, Robey, BR, Magnuson, MA, Granner, DK, Girard, J. Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element. Eur J Biochem, 236(1), 214-21, 1996.

Wang, R, Macmillan, LB, Fremeau, RT, Magnuson, MA, Lindner, J, Limbird, LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5'' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience, 74(1), 199-218, 1996.

Liang, Y, Kesavan, P, Wang, LQ, Niswender, K, Tanizawa, Y, Permutt, MA, Magnuson, MA, Matschinsky, FM. Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. Biochem J, 309 ( Pt 1), 167-73, 1995. PMCID:1135815

Niswender, KD, Blackman, SM, Rohde, L, Magnuson, MA, Piston, DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc, 180 ( Pt 2), 109-16, 1995.

Postic, C, Niswender, KD, Decaux, JF, Parsa, R, Shelton, KD, Gouhot, B, Pettepher, CC, Granner, DK, Girard, J, Magnuson, MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics, 29(3), 740-50, 1995.

Williams, CP, Granner, DK, Magnuson, MA, Chalkley, R. Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene. Biochem Biophys Res Commun, 215(1), 272-9, 1995.

Efrat, S, Leiser, M, Wu, YJ, Fusco-DeMane, D, Emran, OA, Surana, M, Jetton, TL, Magnuson, MA, Weir, G, Fleischer, N. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A, 91(6), 2051-5, 1994. PMCID:43307

Franklin, AJ, Jetton, TL, Shelton, KD, Magnuson, MA. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol Cell Biol, 14(10), 6773-88, 1994. PMCID:359208

Jetton, TL, Liang, Y, Pettepher, CC, Zimmerman, EC, Cox, FG, Horvath, K, Matschinsky, FM, Magnuson, MA. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem, 269(5), 3641-54, 1994.

Lazar, J, Desvergne, B, Zimmerman, EC, Zimmer, DB, Magnuson, MA, Nikodem, VM. A role for intronic sequences on expression of thyroid hormone receptor alpha gene. J Biol Chem, 269(32), 20352-9, 1994.

Liang, Y, Jetton, TL, Zimmerman, EC, Najafi, H, Berner, DK, Matschinsky, FM, Magnuson, MA. Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes, 43(9), 1138-45, 1994.

Meyrick, B, Magnuson, MA. Identification and functional characterization of the bovine manganous superoxide dismutase promoter. Am J Respir Cell Mol Biol, 10(1), 113-21, 1994.

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994. PMCID:295259

Brigham, KL, Meyrick, B, Christman, B, Conary, JT, King, G, Berry, LC, Magnuson, MA. Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice. Am J Respir Cell Mol Biol, 8(2), 209-13, 1993.

Kijima, Y, Saito, A, Jetton, TL, Magnuson, MA, Fleischer, S. Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes. J Biol Chem, 268(5), 3499-506, 1993.

Magnuson, MA, Jetton, TL. Evolutionary conservation of elements in the upstream glucokinase promoter. Biochem Soc Trans, 21(1), 160-3, 1993.

Printz, RL, Magnuson, MA, Granner, DK. Mammalian glucokinase. Annu Rev Nutr, 13, 463-96, 1993.

Jetton, TL, Magnuson, MA. Heterogeneous expression of glucokinase among pancreatic beta cells. Proc Natl Acad Sci U S A, 89(7), 2619-23, 1992. PMCID:48713

Liang, Y, Najafi, H, Smith, RM, Zimmerman, EC, Magnuson, MA, Tal, M, Matschinsky, FM. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes, 41(7), 792-806, 1992.

Magnuson, MA. Tissue-specific regulation of glucokinase gene expression. J Cell Biochem, 48(2), 115-21, 1992.

Shelton, KD, Franklin, AJ, Khoor, A, Beechem, J, Magnuson, MA. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol, 12(10), 4578-89, 1992. PMCID:360385

Short, MK, Clouthier, DE, Schaefer, IM, Hammer, RE, Magnuson, MA, Beale, EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol, 12(3), 1007-20, 1992. PMCID:369533

Liang, Y, Jetton, TL, Zimmerman, EC, Najafi, H, Matschinsky, FM, Magnuson, MA. Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary. J Biol Chem, 266(11), 6999-7007, 1991.

Zimmerman, EC, Jones, CM, Fet, V, Hogan, BL, Magnuson, MA. Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor. Nucleic Acids Res, 19(4), 956, 1991. PMCID:333739

Forest, CD, O''Brien, RM, Lucas, PC, Magnuson, MA, Granner, DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol, 4(9), 1302-10, 1990.

Magnuson, MA. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes, 39(5), 523-7, 1990.

O''Brien, RM, Lucas, PC, Forest, CD, Magnuson, MA, Granner, DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science, 249(4968), 533-7, 1990.

Zimmer, DB, Magnuson, MA. Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. J Histochem Cytochem, 38(2), 171-8, 1990.

Andreone, TL, Printz, RL, Pilkis, SJ, Magnuson, MA, Granner, DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem, 264(1), 363-9, 1989.

Brigham, KL, Meyrick, B, Christman, B, Magnuson, M, King, G, Berry, LC. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am J Med Sci, 298(4), 278-81, 1989.

Magnuson, MA, Andreone, TL, Printz, RL, Koch, S, Granner, DK. Rat glucokinase gene: structure and regulation by insulin. Proc Natl Acad Sci U S A, 86(13), 4838-42, 1989. PMCID:297510

Magnuson, MA, Shelton, KD. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem, 264(27), 15936-42, 1989.

Morioka, H, Magnuson, MA, Mitsuhashi, T, Song, MK, Rall, JE, Nikodem, VM. Structural characterization of the rat malic enzyme gene. Proc Natl Acad Sci U S A, 86(13), 4912-6, 1989. PMCID:297525

Nikodem, VM, Magnuson, MA, Dozin, B, Morioka, H. Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone. Endocr Res, 15(4), 547-64, 1989.

Petersen, DD, Magnuson, MA, Granner, DK. Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol, 8(1), 96-104, 1988. PMCID:363086

Quinn, PG, Wong, TW, Magnuson, MA, Shabb, JB, Granner, DK. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol, 8(8), 3467-75, 1988. PMCID:363584

Magnuson, MA, Quinn, PG, Granner, DK. Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin''s effects oppose those of cAMP and dexamethasone. J Biol Chem, 262(31), 14917-20, 1987.

Dozin, B, Magnuson, MA, Nikodem, VM. Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control. J Biol Chem, 261(22), 10290-2, 1986.

Magnuson, MA, Morioka, H, Tecce, MF, Nikodem, VM. Coding nucleotide sequence of rat liver malic enzyme mRNA. J Biol Chem, 261(3), 1183-6, 1986.

Tecce, MF, Dozin, B, Magnuson, MA, Nikodem, VM. Transcriptional regulation by thyroid hormone of an mRNA homologous to a protease inhibitor. Biochemistry, 25(19), 5831-4, 1986.

Dozin, B, Magnuson, MA, Nikodem, VM. Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry, 24(20), 5581-6, 1985.

Magnuson, MA, Dozin, B, Nikodem, VM. Regulation of specific rat liver messenger ribonucleic acids by triiodothyronine. J Biol Chem, 260(10), 5906-12, 1985.

Magnuson, MA, Nikodem, VM. Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone. J Biol Chem, 258(20), 12712-7, 1983.

Olson, JD, Brockway, WJ, Fass, DN, Magnuson, MA, Bowie, EJ. Evaluation of ristocetin-Willebrand factor assay and ristocetin-induced platelet aggregation. Am J Clin Pathol, 63(2), 210-8, 1975.


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Updated Date
08/12/2013



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