Vanderbilt University School of Medicine

Norden, Jeanette J. , Ph.D.
Professor of Cell and Developmental Biology, Emerita

Lab Url: N/A

Phone Number: (615) 343-3425

Email Address:jeanette.norden@vanderbilt.edu

Norden, Jeanette's picture

Office Address   Mailing Address

4137 MRB III

4137 MRB III 465 21st Ave South 37232


Research Keywords
Nerve Regeneration, Synaptic Plasticity, Medical Education,Neuroscience

Research Description
Research: Our lab was focussed primarily on the study of the molecular response of retinal ganglion cells to optic nerve injury. Our goal was to understand why non-manmmalian vertebrates have the ability to regenerate their optic nerves after injury, while mammals are permanently blind following similar injuries. We were one of the labs which initially identified a group of fast-axonally transported proteins called "growth-associated proteins" or GAPS which were upregulated only under conditions of axon growth during development and regeneration. We were able to demonstrate that retinal ganglion cells in adult rats can be induced to regrow through peripheral nervous system grafts if cut axons are provided with specific growth factors which upregulate the expression of GAPs. Our lab also demonstrated that in the adult mammalian brain GAPs play a role in synaptic plasticity. Finally, other studies in the lab were directed towards understanding the post-translational modification of one of the specific GAP proteins, GAP-43, expressed under conditions of axon growth or synaptic plasticity.

Medical Education: Since 1998, I have devoted myself exclusively to teaching. As Director of Medical Education, I have the pleasure to work with a small, but dedicated, group of award-winning teachers. My own major teaching responsibility is as the Director of the Medical Neuroscience course for second year medical students. The overall goal of my teaching is to stimulate both the intellectual and personal development of students. In the medical course, promoting intellectual growth involves helping students acquire the knowledge base and clinical reasoning skills that will allow them to practice evidence-based medicine. Their personal development is promoted by encouraging self reflection, and by helping them develop interpersonal skills that will allow them to relate to patients in a compassionate and empathic manner. I also teach an undergraduate course in Integrative Neuroscience where students are encouraged to see the interrelationship of knowledge and ideas generated in philosophy, anthropology, and neurosciences.

Part of my scholarly activity involves extensive traveling to other medical centers nationally and internationally to teach Neurosciences or to conduct workshops on effective teaching. I have also acted as a consultant to other medical schools about medical curriculum reform and course design. Most recently, I was appointed as the external evaluator of Science Education Reform in 16 Colleges and Universities funded by the Keck Foundation.







Publications
Hess D.T., Smith, D.S., Patterson, S.I., Kahn, R.A., Skene, J.H. and Norden, J.J. Rapid arrest of axon elongation by brefeldin A: a role for the small GTP-binding protein ARF in neuronal growth cones. J Neurobiol , 38, 105-115, 1999.

McAdory, B S, Van Eldik, L J, Norden, J J. S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. Brain Res, 813(1), 211-7, 1998.

McAdory, B.S., Van Eldik, L.J. and Norden, J.J. S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. Brain Res , 813, 211-7, 1998.

Wouters, B C, Bock-Samson, S, Little, K, Norden, J J. Up-regulation of fast-axonally transported proteins in retinal ganglion cells of adult rats with optic-peroneal nerve grafts. Brain Res Mol Brain Res, 53(1-2), 53-68, 1998.

Wouters, B.C., Bock-Samson, S., Little, K. and Norden, J.J. Up-regulation of fast-axonally transported proteins in retinal ganglion cells of adult rats with optic-peroneal nerve grafts. Brain Res Mol Brain Res , 53, 53-68, 1998.

Hess, D T, Lin, L H, Freeman, J A, Norden, J J. Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide. Neuropharmacology, 33(11), 1283-92, 1994.

Hess, D. T., Lin, L. -H., Freeman, J. A. and Norden, J. J. Modification of cyteine residues within Go and other neuronal proteins by exposure to nitric oxide. Neuropharmacology, 33, 1283-1292, 1994.

Lin, L H, Van Eldik, L J, Osheroff, N, Norden, J J. Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta. Brain Res Mol Brain Res, 25(3-4), 297-304, 1994.

Norden, J J, Constantine-Paton, M. Dynamics of retinotectal synaptogenesis in normal and 3-eyed frogs: evidence for the postsynaptic regulation of synapse number. J Comp Neurol, 348(3), 461-79, 1994.

Lin, L H, Bock, S, Carpenter, K, Rose, M, Norden, J J. Synthesis and transport of GAP-43 in entorhinal cortex neurons and perforant pathway during lesion-induced sprouting and reactive synaptogenesis. Brain Res Mol Brain Res, 14(1-2), 147-53, 1992.

Costello, B, Lin, L H, Meymandi, A, Bock, S, Norden, J J, Freeman, J A. Expression of the growth- and plasticity-associated neuronal protein, GAP-43, in PC12 pheochromocytoma cells. Prog Brain Res, 89, 47-67, 1991.

Norden, J J, Lettes, A, Costello, B, Lin, L H, Wouters, B, Bock, S, Freeman, J A. Possible role of GAP-43 in calcium regulation/neurotransmitter release. Ann N Y Acad Sci, 627, 75-93, 1991.

Norden, J. J., Wouters, B., Knapp, J., Bock, S. and Freeman, J. A. The role of GAP-43 in axon growth and synaptic plasticity in the visual system: Evolutionary implications. Vision and Visual Dysfunction, 11, 219-231, 1991.

McGuire, C B, Snipes, G J, Norden, J J. Light-microscopic immunolocalization of the growth- and plasticity-associated protein GAP-43 in the developing rat brain. Brain Res, 469(1-2), 277-91, 1988.

Snipes, G J, Chan, S Y, McGuire, C B, Costello, B R, Norden, J J, Freeman, J A, Routtenberg, A. Evidence for the coidentification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein. J Neurosci, 7(12), 4066-75, 1987.

Snipes, G. J., Chan, S. Y., McGuire, C. B., Costello, B. R., Norden, J. J., Freeman, J. A. and Routtenberg, A. Evidence for the co-identification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein. J. Neurosci., 7, 4066-4075, 1987.

Snipes, G. J., Costello, B., McGuire, C. B., Mayes, B. N., Bock, S. S., Norden, J. J. and Freeman, J. A. Regulation of specific neuronal and non-neuronal proteins during development and following injury in the rat CNS. Prog. Brain Res, 71, 155-175, 1987.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
08/26/2011



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