Artner, I and Stein, R. Insulin Gene Transcription: The Factors involved in Cell-type-Specific and Glucose-Regulated Expression in Islet beta Cells are also Essential during Pancreatic Development
. , (Review Article- in press), , 2007.
Artner, I., Blanchi, B., Raum, J.C., Guo, M., Kaneko, T., Cordes, S., Sieweke, M., and Stein, R.. MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A, 104(10):3853-8, , 2007.
Oetjen E., Blume R., Cierny I., Schlag C., Kutschenko A., Kratzner R., Stein R., Knepel W.. nhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells.. Diabetologia, in press, , 2007.
Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M.. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.. Mol. Cell. Biol. , 27:4093-104., , 2007.
Wiebe, PO, Kormish, JD, Roper, VT, Fujitani, Y, Alston, NI, Zaret, KS, Wright, CV, Stein, RW, Gannon, M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol, 27(11), 4093-104, 2007. PMCID:1900007
Artner, I., Lelay, J., Hang, Y., Elgazhi, L., Schisler, JC., Henderson, E., Sosa-Pineda, B., and Stein, R. . MafB: A Transcription Factor of the Glucagon Gene in Islet alpha Cells is also Expressed in Alpha Cell Progenitors. Diabetes , 55:297-304, , 2006.
Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV.. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.. Dev. Biol. , 298:616-631, , 2006.
Boyer, DF, Fujitani, Y, Gannon, M, Powers, AC, Stein, RW, Wright, CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol, 298(2), 616-31, 2006.
Fujitani, Y, Fujitani, S, Boyer, DF, Gannon, M, Kawaguchi, Y, Ray, M, Shiota, M, Stein, RW, Magnuson, MA, Wright, CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage
requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev, 20(2), 253-66, 2006. PMCID:1356115
Le Lay, J. and and Stein, R. . Involvement of PDX-1 in Activation of Human Insulin Gene Transcription. J. of Endocrinology, 188(2):287-94, , 2006.
Poitout, V., Hagman. D., Stein, R., Artner, I., Robertson, R.P., and Harmon, J.S. . Regulation of the insulin gene by glucose and fatty acids . J. Nutr. , 136:873-876, (Review Article), 2006.
Raum, J. Gerrish, K., Henderson, E., Guo, M., and Stein, R.. . Islet Beta-Cell Specific Expression of the MafA Transcription Factor is Regulated by FoxA2, Nkx2.2 and PDX-1 Binding to Conserved -8118 to -7748 Sequences. Mol. Cell. Biol., 26(15):5735-43, , 2006.
Tweedie, E., Artner, I, Crawford, L, Poffenberger, G, Thorens, G, Stein, R, Powers, A, and Gannon, M . Maintenance of Hnf6 in postnatal islets impairs terminal differentiation and function of beta cells. Diabetes , 55:3264-3270, , 2006.
Ueki, K., Okada, T., Dahlren, G.M., Peters, J.L., Shacman, J.G., Zhang, M., Artner, I., Satin, L.S., Stein, R., Kennedy, R.T., Kahn, C.R., and Kulkarni, R.N. . Total Insulin/IGF-1 Resistance in Pancreatic Beta-Cells causes Overt Diabetes. Nature Med. , 38:583-588, , 2006.
Harmon, J.S., Stein, R. and Robertson, R.P.. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J. Biol. Chem., 280:11107-11113, , 2005.
Kitamura, Y., Kitamura, T., Kruse, J. -P., Raum, J., Stein, R., Wei, G, and Accili, D. . Dual regulation of FoxO1 activity protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metabolism, 2:153-163, , 2005.
Van Velkinburgh, J.C., Samaras, S., Gerrish, K., Artner, I., and Stein, R.. Interactions between Areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas. . J. Biol. Chem. , 280:38438-44, , 2005.
Zhao, Li, Guo, Min, Matsuoka, Taka-Aki, Hagman, Derek K, Parazzoli, Susan D, Poitout, Vincent, Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of Insulin gene
transcription. J. Biol. Chem., 280, 11887-11894, 2005.
Cockburn, B.N., Bermano, G., Boodram, L.-L., Telllucksingh, S., Tsuchiya, T., Mahabir, D., Allan, A.B., Stein, R., Docherty, K., and Bell, G.I.. Identification and functional characterization of a novel diabetes-associated mutation (E224K) in the IPF-1 (MODY4) gene in an Indo-Trinidadian family. J. Clin. Endo. and Metab., 89, 971-978, 2004.
Gerrish, Kevin, Van Velkinburgh, Jennifer C, Stein, Roland. Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol, 18(3), 533-48, 2004.
Le Lay, John, Matsuoka, Taka-Aki, Henderson, Eva, Stein, Roland. Identification of a novel PDX-1 binding site in the human insulin gene enhancer. J Biol Chem, 279(21), 22228-35, 2004.
Matsuoka, Taka-aki, Artner, Isabella, Henderson, Eva, Means, Anna, Sander, Maike, Stein, Roland. The MafA transcription factor appears to be responsible for tissue-specific
expression of insulin. Proc Natl Acad Sci U S A, 101(9), 2930-3, 2004. PMCID:365722
Qiu, Yi, Guo, Min, Huang, Suming, Stein, Roland. Acetylation of the BETA2 transcription factor by p300-associated factor is
important in insulin gene expression. J Biol Chem, 279(11), 9796-802, 2004.
Review: Poitout, V., Stein, R., and Rhodes, C.J. . Insulin gene expression and biosynthesis. . International Textbook of Diabetes Mellitus. , Volume III, E. Ferrannini, P. Zimmet, R. DeFronzo and H. Keen. Eds. (NYC, New York; John Wiley & Sons), pp. 97-124, 2004.
Cissell, Michelle A, Zhao, Li, Sussel, Lori, Henderson, Eva, Stein, Roland. Transcription factor occupancy of the insulin gene in vivo. Evidence for direct
regulation by Nkx2.2. J Biol Chem, 278(2), 751-6, 2003.
Griffin, David, Penberthy, W Todd, Lum, Helen, Stein, Roland W, Taylor, William L. Isolation of the B3 transcription factor of the Xenopus TFIIIA gene. Gene, 313, 179-88, 2003.
Martin, Cyrus C, Svitek, Christina A, Oeser, James K, Henderson, Eva, Stein, Roland, O''Brien, Richard M. Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell
E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related
protein (IGRP) gene expression. Biochem J, 371(Pt 3), 675-86, 2003. PMCID:1223330
Matsuoka, Taka-aki, Zhao, Li, Artner, Isabella, Jarrett, Harry W, Friedman, David, Means, Anna, Stein, Roland. Members of the large Maf transcription family regulate insulin gene transcription
in islet beta cells. Mol Cell Biol, 23(17), 6049-62, 2003. PMCID:180917
Moates, J.M., Nanda, S., Cissell, M., and Stein, R. . The BETA2 transcription factor binds to and activates expression of the glucokinase gene in beta cells. Diabetes, 52, 403-408, 2003.
Samaras, Susan E, Zhao, Li, Means, Anna, Henderson, Eva, Matsuoka, Taka-Aki, Stein, Roland. The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1
expression. J Biol Chem, 278(14), 12263-70, 2003.
Petersen, H.V., Jensen, J.N., Stein, R., and Serup, P. Glucose induced MAPK signaling influences NeuroD1-mediated activation and nuclear localization. FEBS Letters, 528, 1-3, 2002.
Qiu, Yi, Guo, Min, Huang, Suming, Stein, Roland. Insulin gene transcription is mediated by interactions between the p300 coactivator
and PDX-1, BETA2, and E47. Mol Cell Biol, 22(2), 412-20, 2002. PMCID:139753
Samaras, Susan E, Cissell, Michelle A, Gerrish, Kevin, Wright, Christopher V E, Gannon, Maureen, Stein, Roland. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene
mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol, 22(13), 4702-13, 2002. PMCID:133887
Shih, D.Q., Heimesaat, M.E., Kuwajima, S., Stein, R., Wright, C.V.E., Stoffel, M. Defects in Pancreatic Beta-Cell function in Mice with Combined Heterozygous Mutations in Pdx-1, Hnf-1 alpha and Hnf-3 beta. Proc. Natl. Acad. Sci., 99, 3818-3823, 2002.
Gerrish, K, Cissell, M A, Stein, R. The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation
of the pdx-1 gene. J Biol Chem, 276(51), 47775-84, 2001.
Matsuoka , T, Zhao, L, Stein, R. The DNA binding activity of the RIPE3b1 transcription factor of insulin appears
to be influenced by tyrosine phosphorylation. J Biol Chem, 276(25), 22071-6, 2001.
Review: Stein, R. Insulin gene transcription: the factors involved in cell-type-specific and glucose-regulated expression in islet beta cells are also essential during pancreatic development. Handbook of Physiology. Section 7: The Endocrine System, II(A. Cherrington and J. Jefferson. Eds. (Washington, D.C. American Physiology Society), 25-78, 2001.
Gerrish, K, Gannon, M, Shih, D, Henderson, E, Stoffel, M, Wright, C V, Stein, R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of
conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem, 275(5), 3485-92, 2000.
Peshavaria, M, Cissell, M A, Henderson, E, Petersen, H V, Stein, R. The PDX-1 activation domain provides specific functions necessary for transcriptional
stimulation in pancreatic beta-cells. Mol Endocrinol, 14(12), 1907-17, 2000.
Gannon, M, Gerrish, K., Stein, R., and Wright, C.V.E. Role of pdx-1 in pancreas development. Review for Frontiers in Diabetes: Molecular pathogenesis of MODYs. Editors: F.M. Matschinsky and M.A. Magnuson, S. Karger Publishers., , 166-180, 2000.
Review: Gerrish, K., Samaras, S., Cissell, M.A., Wright, C.V.E., and Stein, R. Regulation of pdx-1 gene expression. Review for Molecular Basis of Pancreatic Development and Function. Editors: M.A. Hussein, C.P. Miller, and J.F. Habener Kluwer Academic Publishers, Nowell, MA., , 251-263, 2000.
Zhao, L, Cissell, M A, Henderson, E, Colbran, R, Stein, R. The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately
43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment. J Biol Chem, 275(14), 10532-7, 2000.
Huang, S, Qiu, Y, Stein, R W, Brandt, S J. p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. Oncogene, 18(35), 4958-67, 1999.
Sharma, A, Moore, M, Marcora, E, Lee, J E, Qiu, Y, Samaras, S, Stein, R. The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize
with those necessary for neurogenesis and p300/CREB binding protein binding. Mol Cell Biol, 19(1), 704-13, 1999. PMCID:83927
Petersen, H.V., Peshavaria, M., Pedersen, A.A., Philippe, J., Stein, R., Madsen, O., and Serup, P. "Glucose Stimulates the Activation Domain Potential of the PDX-1 Homeodomain Transcription Factor.". FEBS Lett., 431, 362-366, 1998.
Qiu, Y, Sharma, A, Stein, R. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators
of the insulin gene. Mol Cell Biol, 18(5), 2957-64, 1998. PMCID:110675
Carty, M.D., Lillquist, J.S., Peshavaria, M., Stein, R., and Soeller, W.C. "Identification of Cis- and Trans-active Factors Regulating Islet Amyloid Polypeptide Expression in Pancreatic b cells.". J. Biol. Chem., 272, 11986-11993, 1997.
Fernandes, A., King, L.C., Guz, Y., Stein, R., Wright, C.V.E., and Teitelman, G. "Differentiation of New Insulin Producing Cells is Induced by Injury in Adult Pancreatic Islets.". Endocrinology, 138, 1750-1762, 1997.
Peshavaria, M, Henderson, E, Sharma, A, Wright, C V, Stein, R. Functional characterization of the transactivation properties of the PDX-1
homeodomain protein. Mol Cell Biol, 17(7), 3987-96, 1997. PMCID:232251
Peshavaria, M. and Stein, R. "PDX-1: An Activator of Genes Involved in Pancreatic Development and Islet Gene Expression.". Review for Pancreas Growth and Regeneration, Editor: Nora Sarvetnick, Molecular Biology Intelligence Unit, Publishers: Karger Landes Systems, , 96-103., 1997.
Sharma, A, Henderson, E, Gamer, L, Zhuang, Y, Stein, R. Analysis of the role of E2A-encoded proteins in insulin gene transcription. Mol Endocrinol, 11(11), 1608-17, 1997.
Wu, K L, Gannon, M, Peshavaria, M, Offield, M F, Henderson, E, Ray, M, Marks, A, Gamer, L W, Wright, C V, Stein, R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific
transcription of the pdx-1 gene. Mol Cell Biol, 17(10), 6002-13, 1997. PMCID:232449
Offield, M F, Jetton, T L, Labosky, P A, Ray, M, Stein, R W, Magnuson, M A, Hogan, B L, Wright, C V. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral
duodenum. Development, 122(3), 983-95, 1996.
Guz, Y., Montminy, M.R., Stein, R., Gamer, L.W., Wright, C.V.E., and Teitelman, G. "Expression of the STF-1 Homeobox Protein Identifies Common Precursors for Endocrine and Exocrine Pancreatic Cells.". Development, 121, 11-18, 1995.
Olson, L.K., Sharma, A., Wright, C.V.E., Towle, H.C., Robertson, R.P., and Stein, R. "Reduction of Insulin Gene Transcription in HIT-T15 b cells Chronically Exposed to a Supraphysiological Glucose Concentration is Associated with Loss of STF-1 Transcription Factor Expression.". Proc. Natl. Acad. Sci., 92, 9127-9131, 1995.
Robinson, G L, Henderson, E, Massari, M E, Murre, C, Stein, R. c-jun inhibits insulin control element-mediated transcription by affecting
the transactivation potential of the E2A gene products. Mol Cell Biol, 15(3), 1398-404, 1995. PMCID:230364
Sharma, A, Fusco-DeMane, D, Henderson, E, Efrat, S, Stein, R. The role of the insulin control element and RIPE3b1 activators in glucose-stimulated
transcription of the insulin gene. Mol Endocrinol, 9(11), 1468-76, 1995.
Sharma, A, Olson, L K, Robertson, R P, Stein, R. The reduction of insulin gene transcription in HIT-T15 beta cells chronically
exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription
factor expression. Mol Endocrinol, 9(9), 1127-34, 1995.
Stoffel, M., Stein, R., Wright, C.V.E., Espinosa, R. III, Le Beau, M.M., and Bell, G.I. "Localization of Human Homeodomain Transcription Factor Insulin Promoter Factor 1 (IPF1) to Chromosome Band 13q12.1". Genomics, 28, 125-126, 1995.
Henderson, E, Stein, R. c-jun inhibits transcriptional activation by the insulin enhancer, and the
insulin control element is the target of control. Mol Cell Biol, 14(1), 655-62, 1994. PMCID:358415
Peshavaria, M, Gamer, L, Henderson, E, Teitelman, G, Wright, C V, Stein, R. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related
to a mammalian insulin gene transcription factor. Mol Endocrinol, 8(6), 806-16, 1994.
Robinson, G L, Cordle, S R, Henderson, E, Weil, P A, Teitelman, G, Stein, R. Isolation and characterization of a novel transcription factor that binds to
and activates insulin control element-mediated expression. Mol Cell Biol, 14(10), 6704-14, 1994. PMCID:359201
Robinson, G L, Peshavaria, M, Henderson, E, Shieh, S Y, Tsai, M J, Teitelman, G, Stein, R. Expression of the trans-active factors that stimulate insulin control element-mediated
activity appear to precede insulin gene transcription. J Biol Chem, 269(4), 2452-60, 1994.
Sharma, A, Stein, R. Glucose-induced transcription of the insulin gene is mediated by factors required
for beta-cell-type-specific expression. Mol Cell Biol, 14(2), 871-9, 1994. PMCID:358441
Stein, R, Henderson, E, Cordle, S R. Analysis of an insulin gene transcription control element. Positive and negative
regulation appears to be mediated by different element sequences. FEBS Lett, 338(2), 187-90, 1994.
Cordle, S R, Henderson, E, Masuoka, H, Weil, P A, Stein, R. Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated
by basic helix-loop-helix DNA-binding proteins. Mol Cell Biol, 11(3), 1734-8, 1991. PMCID:369485
Cordle, S R, Whelan, J, Henderson, E, Masuoka, H, Weil, P A, Stein, R. Insulin gene expression in nonexpressing cells appears to be regulated by multiple
distinct negative-acting control elements. Mol Cell Biol, 11(5), 2881-6, 1991. PMCID:360077
Hicks, B A, Stein, R, Efrat, S, Grant, S, Hanahan, D, Demetriou, A A. Transplantation of beta cells from transgenic mice into nude athymic diabetic
rats restores glucose regulation. Diabetes Res Clin Pract, 14(3), 157-64, 1991.
Pietenpol, J A, M??nger, K, Howley, P M, Stein, R W, Moses, H L. Factor-binding element in the human c-myc promoter involved in transcriptional
regulation by transforming growth factor beta 1 and by the retinoblastoma gene product. Proc Natl Acad Sci U S A, 88(22), 10227-31, 1991. PMCID:52901
Pietenpol, J A, Holt, J T, Stein, R W, Moses, H L. Transforming growth factor beta 1 suppression of c-myc gene transcription:
role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci U S A, 87(10), 3758-62, 1990. PMCID:53982
Pietenpol, J A, Stein, R W, Moran, E, Yaciuk, P, Schlegel, R, Lyons, R M, Pittelkow, M R, M??nger, K, Howley, P M, Moses, H L. TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is
abrogated by viral transforming proteins with pRB binding domains. Cell, 61(5), 777-85, 1990.
Stein, R W, Corrigan, M, Yaciuk, P, Whelan, J, Moran, E. Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton
cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity. J Virol, 64(9), 4421-7, 1990. PMCID:247911
Whelan, J, Cordle, S R, Henderson, E, Weil, P A, Stein, R. Identification of a pancreatic beta-cell insulin gene transcription factor
that binds to and appears to activate cell-type-specific expression: its possible relationship to other
cellular factors that bind to a common insulin gene sequence. Mol Cell Biol, 10(4), 1564-72, 1990. PMCID:362261
Stein, R W, Whelan, J. Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products. Mol Cell Biol, 9(10), 4531-4, 1989. PMCID:362538
Whelan, J, Poon, D, Weil, P A, Stein, R. Pancreatic beta-cell-type-specific expression of the rat insulin II gene is
controlled by positive and negative cellular transcriptional elements. Mol Cell Biol, 9(8), 3253-9, 1989. PMCID:362369