Vanderbilt University School of Medicine

Van Kaer, Luc , Ph.D..
Professor of Pathology, Microbiology and Immunology
Elizabeth and John Shapiro Chair

Lab Url: http://www.mc.vanderbilt.edu/microbio/vankaer/index.html

Phone Number: 615-343-2707

Email Address:luc.van.kaer@Vanderbilt.Edu

Van Kaer, Luc's picture

Office Address   Mailing Address

AA5206A

2363


Research Specialty
Antigen presentation and lymphocyte development

Research Description
We are interested in the basic mechanisms employed by the immune system to fight infection. Our work focuses on the function of a set of molecules encoded within a region of the genome referred to as the major histocompatibility complex (MHC). The MHC products bind with pathogen-derived peptides and present these peptides to T lymphocytes. Two classes of MHC molecule can be distinguished, MHC class I and class II, which present antigens to CD8+ cytotoxic T lymphocytes and CD4+ helper T lymphocytes, respectively.

Current projects in the laboratory include: 1) determine how antigenic peptides are generated and combined with MHC molecules; 2) understand the role of MHC molecules and their natural peptide ligands in the intrathymic selection of a complete repertoire of T lymphocytes; 3) study how the type of MHC molecule that presents a given antigen can influence the type of immune response that is generated against this antigen; and 4) investigate the importance of MHC products for the target cell specificity of natural killer cells, a poorly defined class of lymphocyte that is involved in the immune response against viruses and tumors.

Our general approach to study the immune system is to use mouse genetics. Genetic engineering techniques are now available that allow one to introduce or delete specific genes in a whole mice. Such mice provide unique models to study various aspects of a gene product. Using this technology, our laboratory has generated several new mouse strains which exhibit a variety of immune defects.

Publications
Braun, NA, Mendez-Fernandez, YV, Covarrubias, R, Porcelli, SA, Savage, PB, Yagita, H, Van Kaer, L, Major, AS. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler Thromb Vasc Biol, 30(9), 1758-65, 2010.

Hao, J, Liu, R, Piao, W, Zhou, Q, Vollmer, TL, Campagnolo, DI, Xiang, R, La Cava, A, Van Kaer, L, Shi, FD. Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J Exp Med, , , 2010.

Hoek, KL, Gordy, LE, Collins, PL, Parekh, VV, Aune, TM, Joyce, S, Thomas, JW, Van Kaer, L, Sebzda, E. Follicular B Cell Trafficking within the Spleen Actively Restricts Humoral Immune Responses. Immunity, 33(2), 254-265, 2010.

Liu, R, Zhou, Q, La Cava, A, Campagnolo, DI, Van Kaer, L, Shi, FD. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol, 40(6), 1577-89, 2010.

Van Kaer, L, Joyce, S. The Hunt for iNKT Cell Antigens: alpha-Galactosidase-Deficient Mice to the Rescue. Immunity, 33(2), 143-145, 2010.

Van Kaer, L, Parekh, VV, Wu, L. Invariant natural killer T cells: bridging innate and adaptive immunity. Cell Tissue Res, , , 2010.

Zu, L, Bedja, D, Fox-Talbot, K, Gabrielson, KL, Van Kaer, L, Becker, LC, Cai, ZP. Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J Mol Cell Cardiol, 49(1), 5-15, 2010.

Das, J, Ren, G, Zhang, L, Roberts, AI, Zhao, X, Bothwell, AL, Van Kaer, L, Shi, Y, Das, G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med, 206(11), 2407-16, 2009. PMCID:2768861

Moens, L, Jeurissen, A, Nierkens, S, Boon, L, Van Kaer, L, Kasran, A, Wuyts, G, Ceuppens, JL, Bossuyt, X. Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice. Infect Immun, 77(5), 1976-80, 2009. PMCID:2681747

Moore, ML, Newcomb, DC, Parekh, VV, Van Kaer, L, Collins, RD, Zhou, W, Goleniewska, K, Chi, MH, Mitchell, D, Boyce, JA, Durbin, JE, Sturkie, C, Peebles, RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol, 183(3), 2016-26, 2009. PMCID:2768861

Parekh, VV, Lalani, S, Kim, S, Halder, R, Azuma, M, Yagita, H, Kumar, V, Wu, L, Kaer, LV. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol, 182(5), 2816-26, 2009. PMCID:2709814

Sadagopal, S, Braunstein, M, Hager, CC, Wei, J, Daniel, AK, Bochan, MR, Crozier, I, Smith, NE, Gates, HO, Barnett, L, Van Kaer, L, Price, JO, Blackwell, TS, Kalams, SA, Kernodle, DS. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS One, 4(5), e5531, 2009. PMCID:2677452

Wu, L, Gabriel, CL, Parekh, VV, Van Kaer, L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens, 73(6), 535-45, 2009. PMCID:2677452

Wu, L, Van Kaer, L. Natural killer T cells and autoimmune disease. Curr Mol Med, 9(1), 4-14, 2009. PMCID:2709814

Adeeku, E, Gudapati, P, Mendez-Fernandez, Y, Van Kaer, L, Boothby, M. Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc Natl Acad Sci U S A, 105(27), 9307-12, 2008. PMCID:2453725

Cai, ZP, Shen, Z, Van Kaer, L, Becker, LC. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J, 22(12), 4248-57, 2008. PMCID:2614607

Diao, H, Iwabuchi, K, Li, L, Onoe, K, Van Kaer, L, Kon, S, Saito, Y, Morimoto, J, Denhardt, DT, Rittling, S, Uede, T. Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A, 105(41), 15884-9, 2008. PMCID:2560993

Joyce, S, Van Kaer, L. Lung NKT cell commotion takes your breath away. Nat Med, 14(6), 609-10, 2008. PMCID:2453725

Joyce, S, Van Kaer, L. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host Microbe, 3(5), 275-7, 2008.

Kim, S, Lalani, S, Parekh, VV, Vincent, TL, Wu, L, Van Kaer, L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest, 118(6), 2301-15, 2008. PMCID:2350429

Kim, S, Lalani, S, Parekh, VV, Wu, L, Van Kaer, L. Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines, 7(10), 1519-32, 2008. PMCID:2680388

Ni, CY, Wu, ZH, Florence, WC, Parekh, VV, Arrate, MP, Pierce, S, Schweitzer, B, Van Kaer, L, Joyce, S, Miyamoto, S, Ballard, DW, Oltz, EM. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol, 180(11), 7107-11, 2008. PMCID:2601684

Olivares-Villag??mez, D, Mendez-Fernandez, YV, Parekh, VV, Lalani, S, Vincent, TL, Cheroutre, H, Van Kaer, L. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U S A, 105(46), 17931-6, 2008. PMCID:2584730

Van Kaer, L. Pillars of immunology. Antigen presentation: discovery of the peptide TAP. J Immunol, 180(5), 2723-4, 2008.

Medeiros, MM, Peixoto, JR, Oliveira, AC, Cardilo-Reis, L, Koatz, VL, Van Kaer, L, Previato, JO, Mendon??a-Previato, L, Nobrega, A, Bellio, M. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J Leukoc Biol, 82(3), 488-96, 2007.

Parekh, VV, Lalani, S, Van Kaer, L. The in vivo response of invariant natural killer T cells to glycolipid antigens. Int Rev Immunol, 26(1-2), 31-48, 2007.

Puttaparthi, K, Van Kaer, L, Elliott, JL. Assessing the role of immuno-proteasomes in a mouse model of familial ALS. Exp Neurol, 206(1), 53-8, 2007. PMCID:2692686

Van Kaer, L. NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol, 19(3), 354-64, 2007.

Wu, L, Van Kaer, L. NKT cells and diabetes. Am J Physiol Gastrointest Liver Physiol, 293, G919-G922, 2007.

Yang, JQ, Wen, X, Liu, H, Folayan, G, Dong, X, Zhou, M, Van Kaer, L, Singh, RR. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum, 56(4), 1219-33, 2007. PMCID:2291538

Bezbradica, JS, Gordy, LE, Stanic, AK, Dragovic, S, Hill, T, Hawiger, J, Unutmaz, D, Van Kaer, L, Joyce, S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity, 25(3), 487-97, 2006.

Das, G, Das, J, Eynott, P, Zhang, Y, Bothwell, AL, Van Kaer, L, Shi, Y. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med, 203(12), 2603-11, 2006. PMCID:2118151

Das, J, Eynott, P, Jupp, R, Bothwell, A, Van Kaer, L, Shi, Y, Das, G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med, 12(12), 1345-6; author reply 1347, 2006.

La Cava, A, Van Kaer, L, Fu-Dong-Shi, . CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol, 27(7), 322-7, 2006.

Liu, R, Van Kaer, L, La Cava, A, Price, M, Campagnolo, DI, Collins, M, Young, DA, Vollmer, TL, Shi, FD. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol, 176(9), 5247-54, 2006.

Major, AS, Joyce, S, Van Kaer, L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med, 12(6), 270-8, 2006.

Major, AS, Singh, RR, Joyce, S, Van Kaer, L. The role of invariant natural killer T cells in lupus and atherogenesis. Immunol Res, 34(1), 49-66, 2006. PMCID:2291524

Renukaradhya, GJ, Sriram, V, Du, W, Gervay-Hague, J, Van Kaer, L, Brutkiewicz, RR. Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. Int J Cancer, , , 2006.

Shi, FD, Van Kaer, L. Reciprocal regulation between natural killer cells and autoreactive T cells. Nat Rev Immunol, 6(10), 751-60, 2006.

Van Kaer, L, Joyce, S. Viral evasion of antigen presentation: not just for peptides anymore. Nat Immunol, 7(8), 795-7, 2006.

Yan, J, Parekh, VV, Mendez-Fernandez, Y, Olivares-Villag??mez, D, Dragovic, S, Hill, T, Roopenian, DC, Joyce, S, Van Kaer, L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med, 203, 647-659, 2006. PMCID:2118255

Beilke, JN, Kuhl, NR, Van Kaer, L, Gill, RG. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med, 11(10), 1059-65, 2005.

Bezbradica, JS, Hill, T, Stanic, AK, Van Kaer, L, Joyce, S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci U S A, 102(14), 5114-9, 2005. PMCID:555981

Bezbradica, JS, Stanic, AK, Matsuki, N, Bour-Jordan, H, Bluestone, JA, Thomas, JW, Unutmaz, D, Van Kaer, L, Joyce, S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol, 174(8), 4696-705, 2005.

Parekh, VV, Wilson, MT, Olivares-Villag??mez, D, Singh, AK, Wu, L, Wang, CR, Joyce, S, Van Kaer, L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest, 115(9), 2572-83, 2005. PMCID:1193878

Parekh, VV, Wilson, MT, Van Kaer, L. iNKT-cell responses to glycolipids. Crit Rev Immunol, 25(3), 183-213, 2005.

Singh, AK, Yang, JQ, Parekh, VV, Wei, J, Wang, CR, Joyce, S, Singh, RR, Van Kaer, L. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur J Immunol, 35(4), 1143-54, 2005. PMCID:2291523

Van Kaer, L. alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol, 5(1), 31-42, 2005.

Van Kaer, L, Joyce, S. Innate immunity: NKT cells in the spotlight. Curr Biol, 15(11), R429-31, 2005.

Diao, H, Kon, S, Iwabuchi, K, Kimura, C, Morimoto, J, Ito, D, Segawa, T, Maeda, M, Hamuro, J, Nakayama, T, Taniguchi, M, Yagita, H, Van Kaer, L, On??e, K, Denhardt, D, Rittling, S, Uede, T. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity, 21(4), 539-50, 2004.

Godfrey, DI, MacDonald, HR, Kronenberg, M, Smyth, MJ, Van Kaer, L. NKT cells: what's in a name. Nat Rev Immunol, 4(3), 231-7, 2004.

Li, L, Sullivan, BA, Aldrich, CJ, Soloski, MJ, Forman, J, Grandea, AG, Jensen, PE, Van Kaer, L. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol, 173(6), 3707-15, 2004.

Parekh, VV, Singh, AK, Wilson, MT, Olivares-Villag??mez, D, Bezbradica, JS, Inazawa, H, Ehara, H, Sakai, T, Serizawa, I, Wu, L, Wang, CR, Joyce, S, Van Kaer, L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J Immunol, 173(6), 3693-706, 2004.

Van Kaer, L. Regulation of immune responses by CD1d-restricted natural killer T cells. Immunol Res, 30(2), 139-53, 2004.

Joyce, Sebastian, Van Kaer, Luc. CD1-restricted antigen presentation: an oily matter. Curr Opin Immunol, 15(1), 95-104, 2003.

Stanic, Aleksandar K, De Silva, A Dharshan, Park, Jang-June, Sriram, Venkataraman, Ichikawa, Shinichi, Hirabyashi, Yoshio, Hayakawa, Kyoko, Van Kaer, Luc, Brutkiewicz, Randy R, Joyce, Sebastian. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci U S A, 100(4), 1849-54, 2003. PMCID:149922

Wilson, M T, Van Kaer, L. Natural killer T cells as targets for therapeutic intervention in autoimmune diseases. Curr Pharm Des, 9(3), 201-20, 2003.

Wilson, MT, Johansson, C, Olivares-Villag??mez, D, Singh, AK, Stanic, AK, Wang, CR, Joyce, S, Wick, MJ, Van Kaer, L. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci U S A, 100(19), 10913-8, 2003. PMCID:196902

Yang, J.-Q., Saxena, V., Xu, H., Van Kaer, L., Wang, C.-R., and Singh, R.R. Repeated -galactosylceramide administration results in expansion of NKT cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. . J. Immunol, 171, 4439-4446, 2003.

Yoshimoto, Tomohiro, Min, Booki, Sugimoto, Takaaki, Hayashi, Nobuki, Ishikawa, Yuriko, Sasaki, Yuki, Hata, Hitomi, Takeda, Kazuyoshi, Okumura, Ko, Van Kaer, Luc, Paul, William E, Nakanishi, Kenji. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med, 197(8), 997-1005, 2003. PMCID:2193873

Zhang, J, Dong, M, Li, L, Fan, Y, Pathre, P, Dong, J, Lou, D, Wells, JM, Olivares-Villag??mez, D, Van Kaer, L, Wang, X, Xu, M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci U S A, 100(26), 15782-7, 2003. PMCID:307645

Gonzalez-Aseguinolaza, Gloria, Van Kaer, Luc, Bergmann, Cornelia C, Wilson, James M, Schmieg, John, Kronenberg, Mitchell, Nakayama, Toshinori, Taniguchi, Masaru, Koezuka, Yasuhiko, Tsuji, Moriya. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med, 195(5), 617-24, 2002. PMCID:2193764

Motsinger, Alison, Haas, David W, Stanic, Aleksandar K, Van Kaer, Luc, Joyce, Sebastian, Unutmaz, Derya. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med, 195(7), 869-79, 2002. PMCID:2193731

Van Kaer, L. Major histocompatibility complex class I-restricted antigen processing and presentation. Tissue Antigens, 60(1), 1-9, 2002.

Wilson, Michael T, Singh, Avneesh K, Van Kaer, Luc. Immunotherapy with ligands of natural killer T cells. Trends Mol Med, 8(5), 225-31, 2002.

Grandea, A G, Van Kaer, L. Tapasin: an ER chaperone that controls MHC class I assembly with peptide. Trends Immunol, 22(4), 194-9, 2001.

Hong, S, Wilson, M T, Serizawa, I, Wu, L, Singh, N, Naidenko, O V, Miura, T, Haba, T, Scherer, D C, Wei, J, Kronenberg, M, Koezuka, Y, Van Kaer, L. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med, 7(9), 1052-6, 2001.

Seino, K I, Fukao, K, Muramoto, K, Yanagisawa, K, Takada, Y, Kakuta, S, Iwakura, Y, Van Kaer, L, Takeda, K, Nakayama, T, Taniguchi, M, Bashuda, H, Yagita, H, Okumura, K. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci U S A, 98(5), 2577-81, 2001. PMCID:30180

Singh, A K, Wilson, M T, Hong, S, Olivares-Villag??mez, D, Du, C, Stanic, A K, Joyce, S, Sriram, S, Koezuka, Y, Van Kaer, L. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med, 194(12), 1801-11, 2001. PMCID:2193577

Van Kaer, L. Accessory proteins that control the assembly of MHC molecules with peptides. Immunol Res, 23(2-3), 205-14, 2001.

Das, G, Gould, D S, Augustine, M M, Fragoso, G, Sciutto, E, Stroynowski, I, Van Kaer, L, Schust, D J, Ploegh, H, Janeway, C A, Scitto, E. Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. J Exp Med, 192(10), 1521-8, 2000. PMCID:2193183

Felix, N J, Brickey, W J, Griffiths, R, Zhang, J, Van Kaer, L, Coffman, T, Ting, J P. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med, 192(1), 31-40, 2000. PMCID:1887714

Gonzalez-Aseguinolaza, G, de Oliveira, C, Tomaska, M, Hong, S, Bruna-Romero, O, Nakayama, T, Taniguchi, M, Bendelac, A, Van Kaer, L, Koezuka, Y, Tsuji, M. alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc Natl Acad Sci U S A, 97(15), 8461-6, 2000. PMCID:26970

Grandea, A G, Golovina, T N, Hamilton, S E, Sriram, V, Spies, T, Brutkiewicz, R R, Harty, J T, Eisenlohr, L C, Van Kaer, L. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity, 13(2), 213-22, 2000.

Hicks, G G, Singh, N, Nashabi, A, Mai, S, Bozek, G, Klewes, L, Arapovic, D, White, E K, Koury, M J, Oltz, E M, Van Kaer, L, Ruley, H E. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet, 24(2), 175-9, 2000.

Kovalik, J P, Singh, N, Mendiratta, S K, Martin, W D, Ignatowicz, L, Van Kaer, L. The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination. J Immunol, 165(3), 1285-93, 2000.

Shi, F D, Wang, H B, Li, H, Hong, S, Taniguchi, M, Link, H, Van Kaer, L, Ljunggren, H G. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol, 1(3), 245-51, 2000.

Sousa, A O, Mazzaccaro, R J, Russell, R G, Lee, F K, Turner, O C, Hong, S, Van Kaer, L, Bloom, B R. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc Natl Acad Sci U S A, 97(8), 4204-8, 2000. PMCID:18197

Takeda, K, Hayakawa, Y, Van Kaer, L, Matsuda, H, Yagita, H, Okumura, K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A, 97(10), 5498-503, 2000. PMCID:25857

Hong, S, Scherer, D C, Singh, N, Mendiratta, S K, Serizawa, I, Koezuka, Y, Van Kaer, L. Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice. Immunol Rev, 169, 31-44, 1999.

Hong, S, Van Kaer, L. Immune privilege: keeping an eye on natural killer T cells. J Exp Med, 190(9), 1197-200, 1999. PMCID:2195673

Kitamura, H, Iwakabe, K, Yahata, T, Nishimura, S, Ohta, A, Ohmi, Y, Sato, M, Takeda, K, Okumura, K, Van Kaer, L, Kawano, T, Taniguchi, M, Nishimura, T. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med, 189(7), 1121-8, 1999. PMCID:2193012

Korsgren, M, Persson, C G, Sundler, F, Bjerke, T, Hansson, T, Chambers, B J, Hong, S, Van Kaer, L, Ljunggren, H G, Korsgren, O. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J Exp Med, 189(3), 553-62, 1999. PMCID:2192913

Mendiratta, S K, Kovalik, J P, Hong, S, Singh, N, Martin, W D, Van Kaer, L. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol, 11(3), 351-60, 1999.

Singh, N, Hong, S, Scherer, D C, Serizawa, I, Burdin, N, Kronenberg, M, Koezuka, Y, Van Kaer, L. Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol, 163(5), 2373-7, 1999.

Singh, N, Van Kaer, L. Unexpected reactivities of T cells selected by a single MHC-peptide ligand. J Immunol, 163(7), 3583-91, 1999.

Bikoff, E K, Kenty, G, Van Kaer, L. Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms. J Immunol, 160(7), 3101-10, 1998.

Griffin, TA, Nandi, D, Cruz, M, Fehling, HJ, Kaer, LV, Monaco, JJ, Colbert, RA. Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J Exp Med, 187(1), 97-104, 1998. PMCID:2199179

Kovats, S, Grubin, C E, Eastman, S, deRoos, P, Dongre, A, Van Kaer, L, Rudensky, A Y. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med, 187(2), 245-51, 1998. PMCID:2212101

Zhang, J, Liu, X, Scherer, D C, van Kaer, L, Wang, X, Xu, M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A, 95(21), 12480-5, 1998. PMCID:22856

Mendiratta, S K, Martin, W D, Hong, S, Boesteanu, A, Joyce, S, Van Kaer, L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity, 6(4), 469-77, 1997.

Sant'Angelo, D B, Waterbury, P G, Cohen, B E, Martin, W D, Van Kaer, L, Hayday, A C, Janeway, C A. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity, 7(4), 517-24, 1997.

Joyce, S, Negishi, I, Boesteanu, A, DeSilva, A D, Sharma, P, Chorney, M J, Loh, D Y, Van Kaer, L. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med, 184(4), 1579-84, 1996. PMCID:2192848

Martin, W D, Hicks, G G, Mendiratta, S K, Leva, H I, Ruley, H E, Van Kaer, L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell, 84(4), 543-50, 1996.

Machold, R P, Andr??e, S, Van Kaer, L, Ljunggren, H G, Ploegh, H L. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J Exp Med, 181(3), 1111-22, 1995. PMCID:2191915

Martien van Santen, H, Woolsey, A, Rickardt, P G, Van Kaer, L, Baas, E J, Berns, A, Tonegawa, S, Ploegh, H L. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J Exp Med, 181(2), 787-92, 1995. PMCID:2191882

Aldrich, C J, Ljunggren, H G, Van Kaer, L, Ashton-Rickardt, P G, Tonegawa, S, Forman, J. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A, 91(14), 6525-8, 1994. PMCID:44235

Ashton-Rickardt, P G, Bandeira, A, Delaney, J R, Van Kaer, L, Pircher, H P, Zinkernagel, R M, Tonegawa, S. Evidence for a differential avidity model of T cell selection in the thymus. Cell, 76(4), 651-63, 1994.

Ljunggren, H G, Van Kaer, L, Ploegh, H L, Tonegawa, S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proc Natl Acad Sci U S A, 91(14), 6520-4, 1994. PMCID:44234

Van Kaer, L, Ashton-Rickardt, P G, Eichelberger, M, Gaczynska, M, Nagashima, K, Rock, K L, Goldberg, A L, Doherty, P C, Tonegawa, S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity, 1(7), 533-41, 1994.

Ashton-Rickardt, P G, Van Kaer, L, Schumacher, T N, Ploegh, H L, Tonegawa, S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell, 73(5), 1041-9, 1993.

Moriwaki, S, Korn, B S, Ichikawa, Y, van Kaer, L, Tonegawa, S. Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor. Proc Natl Acad Sci U S A, 90(23), 11396-400, 1993. PMCID:47989

Van Kaer, L, Ashton-Rickardt, P G, Ploegh, H L, Tonegawa, S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell, 71(7), 1205-14, 1992.

Van Kaer, L, Wu, M, Ichikawa, Y, Ito, K, Bonneville, M, Ostrand-Rosenberg, S, Murphy, D B, Tonegawa, S. Recognition of MHC TL gene products by gamma delta T cells. Immunol Rev, 120, 89-115, 1991.

Wu, M, van Kaer, L, Itohara, S, Tonegawa, S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J Exp Med, 174(1), 213-8, 1991. PMCID:2118879

Ito, K, Van Kaer, L, Bonneville, M, Hsu, S, Murphy, D B, Tonegawa, S. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell, 62(3), 549-61, 1990.


Postdoctoral Position Available
Yes

Postdoctoral Position Details
A postdoctoral position is available immediately to perform research in the areas of antigen presentation, lymphocyte development and/or autoimmunity. We employ transgenic and knockout approaches to answer important questions in these areas. Relevant publications include: Martin et al. 1996. Cell 84:543-550; Mendiratta et al. 1997. Immunity 6:469-477; Grandea et al. 2000. Immunity 13:213-222; Hong et al. 2001. Nat. Med. 7:1052-1056. Applicants should have a Ph.D. or M.D. and a strong background in molecular biology and cellular immunology.

Interested individuals should send their CV, bibliography, and the names of three references by email . luc.van.kaer@Vanderbilt.Edu

Lab website:http://www.mc.Vanderbilt.Edu/microbio/vankaer/

Updated Date
01/20/2012



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