Vanderbilt University School of Medicine

Ansari, Mohammad Sib , M.S.

Lab Url: http://Radiology PET

Phone Number: (615) 343-7405

Email Address:mohammad.s.ansari@vanderbilt.edu

Ansari, Mohammad's picture

Office Address   Mailing Address

1275 RRB

Vanderbilt University Medical Center 1161 21st Ave South 37232-2675


Research Keywords
PET Radiopharmaceutical / Blood metabolite studies etc.

Research Specialty
Preparation of PET radiopharmaceuticals. Characterization of PET/ SPECT ligands for modeling of imaging studies Autoradiography of postmortem brain of human, monkey and rats.

Research Description
Neuroscience/ Radiochemistry.
Preparation of high specific activity radioligands such as [18F] Fallypride, [18F] DT2B (Avid 133), [18F] FLT, [18F] FMIZO, [18F] Setoperone, [18F] FECENT, [18F] FPEB, [11C] Acetate, etc. for PET imaging of human, animal, and in vivo and in vitro studies.

Characterization of PET ligands for brain receptor studies.

Optimization of preparative HPLC for isolation and separation of PET radioisotopes.

Application and modification of novel techniques for radio ligand synthesis module. Along with hybridization of conventional and microwave synthesis.

Publications
Riccardi, P, Baldwin, R, Salomon, R, Anderson, S, Ansari, MS, Li, R, Dawant, B, Bauernfeind, A, Schmidt, D, Kessler, R. Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride. Biol Psychiatry, 63(2), 241-4, 2008.

Kessler, RM, Ansari, MS, Riccardi, P, Li, R, Jayathilake, K, Dawant, B, Meltzer, HY. Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine. Neuropsychopharmacology, 31(9), 1991-2001, 2006.

Riccardi, P, Li, R, Ansari, MS, Zald, D, Park, S, Dawant, B, Anderson, S, Doop, M, Woodward, N, Schoenberg, E, Schmidt, D, Baldwin, R, Kessler, R. Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans. Neuropsychopharmacology, 31(5), 1016-26, 2006.

Riccardi, P, Zald, D, Li, R, Park, S, Ansari, MS, Dawant, B, Anderson, S, Woodward, N, Schmidt, D, Baldwin, R, Kessler, R. Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study. Am J Psychiatry, 163(9), 1639-41, 2006.

Kessler, RM, Ansari, MS, Riccardi, P, Li, R, Jayathilake, K, Dawant, B, Meltzer, HY. Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol. Neuropsychopharmacology, 30(12), 2283-9, 2005.

Rieck, Richard W, Ansari, M S, Whetsell, William O, Deutch, Ariel Y, Kessler, Robert M. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology, 29(2), 362-72, 2004.

Hewlett, W A, Trevedi, B L, Zhang, Z J, de Paulis, T, Schmidt, D E, Lovinger, D M, Ansari, M S, Ebert, M J. Characterization of (S)-des-4-amino-3-[125I]iodozacopride ([125I]DAIZAC), a selective high-affinity radioligand for 5-hydroxytryptamine3 receptors. J Pharmacol Exp Ther, 288(1), 221-31, 1999.

Kessler RM, Whetsell WO, Ansari MS, Taminga CA, Mason NS. [125I] epidepride binding in post mortem human brain. Schizophr Res, 15(1-2), 62, 1995.

Votaw, J R, Ansari, M S, Mason, N S, Schmidt, D, de Paulis, T, Holburn, G, Clanton, J A, Votaw, D B, Manning, R G, Kessler, R M. Dosimetry of iodine-123-epidepride: a dopamine D2 receptor ligand. J Nucl Med, 36(7), 1316-21, 1995.

Kessler, R M, Votaw, J R, Schmidt, D E, Ansari, M S, Holdeman, K P, de Paulis, T, Clanton, J A, Pfeffer, R, Manning, R G, Ebert, M H. High affinity dopamine D2 receptor radioligands. 3. [123I] and [125I]epidepride: in vivo studies in rhesus monkey brain and comparison with in vitro pharmacokinetics in rat brain. Life Sci, 53(3), 241-50, 1993.

Kessler, R M, Votaw, J R, de Paulis, T, Bingham, D R, Ansari, M S, Mason, N S, Holburn, G, Schmidt, D E, Votaw, D B, Manning, R G. Evaluation of 5-[18F]fluoropropylepidepride as a potential PET radioligand for imaging dopamine D2 receptors. Synapse, 15(3), 169-76, 1993.

Kessler, R M, Whetsell, W O, Ansari, M S, Votaw, J R, de Paulis, T, Clanton, J A, Schmidt, D E, Mason, N S, Manning, R G. Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride. Brain Res, 609(1-2), 237-43, 1993.

Hoff, S J, Stewart, J R, Frist, W H, Kessler, R M, Sandler, M P, Atkinson, J B, Votaw, J, Carey, J A, Ansari, M S, Merrill, W H. Noninvasive detection of heart transplant rejection with positron emission scintigraphy. Ann Thorac Surg, 53(4), 572-7, 1992.

Kessler, R M, Mason, N S, Votaw, J R, De Paulis, T, Clanton, J A, Ansari, M S, Schmidt, D E, Manning, R G, Bell, R L. Visualization of extrastriatal dopamine D2 receptors in the human brain. Eur J Pharmacol, 223(1), 105-7, 1992.

Clanton JA, de Paulis T, Schmidt DE, Ansari MS, Manning RG, Baldwin RM, Kessler RM. Radiolabelling of (S)-N-[(1-ethyl-2-pyrrolidinyl)]-5-iodo-2,3-dimethoxylbenzamide, preparation of [123I] and [125I]epidepride. J Label. Comp. Radiopharm, 29, 745-751, 1991.

Kessler, R M, Ansari, M S, Schmidt, D E, de Paulis, T, Clanton, J A, Innis, R, al-Tikriti, M, Manning, R G, Gillespie, D. High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors. Life Sci, 49(8), 617-28, 1991.

Kessler, R M, Ansari, M S, de Paulis, T, Schmidt, D E, Clanton, J A, Smith, H E, Manning, R G, Gillespie, D, Ebert, M H. High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides. J Nucl Med, 32(8), 1593-600, 1991.


Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
10/13/2008



Vanderbilt University is committed to principles of equal opportunity and affirmative action.
Copyright 2008 Vanderbilt University School of Medicine
The office of Biomedical Research Education & Training All rights reserved.
For questions or problems concerning this page, please submit a help ticket.